Figure 1: The survival curves and body weights of mice. (a) The Kaplan-Meier survival curves of male ( ) and male ( ) mice (generalized Wilcoxon test, ). Bold and thin lines indicate and mice, respectively. (b) The Kaplan-Meier survival curves of female ( ) and female ( ) mice (generalized Wilcoxon test, ). (c, d) The body weights of male (c) and female (d) mice. The male mice ( ) showed significantly decreased body weight compared to that of male mice ( ) from 9 to 25 months of age, while the female mice ( ) failed to show any significant difference compared to the female mice ( ). Closed triangles and closed diamonds indicate and mice, respectively.