Figure 2: The blood glucose and serum insulin concentrations in mice. (a) The blood glucose concentrations of fasting mutant male and female mice were assessed. All mice exhibited blood glucose concentrations within the same range as the mice ( for each genotype). (b) The serum insulin concentrations were determined in the nonfasting state of 4- and 9-month-old and mice ( for each genotype). (c) The serum insulin concentrations were determined in the fasting state of 25-month-old and mice ( for each genotype). The insulin concentrations were significantly increased in both female and male mice compared with the mice. (d, e) The histochemical analyses of the pancreas of mice. (d) The male mice exhibited extensive enlargement of the Langerhans islets compared to mice. (e) In addition, the size of islets in female mice was larger than in female mice. The scale bars indicate 200 μm. *, ** by Student’s -test.