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Figure 4: Adiposity, bone density, food intake, reproduction, rectal temperature, and respiratory quotients of the mice. (a) Both male and female mice showed a significantly decreased fat ratio compared to mice at 20 months of age. (b) Both male and female mice showed significantly increased bone density compared to the mice at 20 months of age. Aged male ( ), female ( ), male ( ), and female ( ) mice were evaluated by DEXA. (c) The food intake of male and male mice at 4, 11, and 17 months of age. No significant difference was observed between the food consumption by ( ) and ( ) mice. (d) The reproduction rate of female mice. No significant difference was observed between and mice (at least 3 mice per genotype). (e) The rectal temperatures of and mice at 4 months of age. No significant differences were observed in the temperatures between the and mice ( for each genotype). * , ** by Student’s -test. (f) The mean time course of respiratory quotients (RQ = VCO2/VO2) of male mice at 5 months of age. The values represent the mean of 24 hours of measurements from each animal ( , male). * by Student’s -test.