- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Journal of Aging Research
Volume 2011 (2011), Article ID 315640, 10 pages
Lifespan and Glucose Metabolism in Insulin Receptor Mutant Mice
1Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
2Applied Biological Chemistry, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu-shi, Tokyo 183-8509, Japan
3Department of Aging Control Medicine, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-0033, Japan
Received 13 February 2011; Revised 15 April 2011; Accepted 19 May 2011
Academic Editor: Christian Sell
Copyright © 2011 Takahiko Shimizu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- C. Kenyon, “The plasticity of aging: insights from long-lived mutants,” Cell, vol. 120, no. 4, pp. 449–460, 2005.
- L. Partridge, D. Gems, and D. J. Withers, “Sex and death: what is the connection?” Cell, vol. 120, no. 4, pp. 461–472, 2005.
- C. Kenyon, J. Chang, E. Gensch, A. Rudner, and R. Tabtiang, “A C. elegans mutant that lives twice as long as wild type,” Nature, vol. 366, no. 6454, pp. 461–464, 1993.
- K. D. Kimura, H. A. Tissenbaum, Y. Liu, and G. Ruvkun, “Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans,” Science, vol. 277, no. 5328, pp. 942–946, 1997.
- K. Lin, J. B. Dorman, A. Rodan, and C. Kenyon, “daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans,” Science, vol. 278, no. 5341, pp. 1319–1322, 1997.
- S. Ogg, S. Paradis, S. Gottlieb et al., “The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans,” Nature, vol. 389, no. 6654, pp. 994–999, 1997.
- M. Tatar, A. Kopelman, D. Epstein, M. P. Tu, C. M. Yin, and R. S. Garofalo, “A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function,” Science, vol. 292, no. 5514, pp. 107–110, 2001.
- D. J. Clancy, D. Gems, L. G. Harshman et al., “Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein,” Science, vol. 292, no. 5514, pp. 104–106, 2001.
- A. Bartke and H. Brown-Borg, “Life extension in the dwarf mouse,” Current Topics in Developmental Biology, vol. 63, pp. 189–225, 2004.
- E. M. Eicher and W. G. Beamer, “New mouse dw allele: genetic location and effects on lifespan and growth hormone levels,” Journal of Heredity, vol. 71, no. 3, pp. 187–190, 1980.
- K. T. Coschigano, D. Clemmons, L. L. Bellush, and J. J. Kopchick, “Assessment of growth parameters and life span of GHR/BP gene-disrupted mice,” Endocrinology, vol. 141, no. 7, pp. 2608–2613, 2000.
- B. Duvillié, N. Cordonnier, L. Deltour et al., “Phenotypic alterations in insulin-deficient mutant mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 10, pp. 5137–5140, 1997.
- J. Baker, J. P. Liu, E. J. Robertson, and A. Efstratiadis, “Role of insulin-like growth factors in embryonic and postnatal growth,” Cell, vol. 75, no. 1, pp. 73–82, 1993.
- D. Accili, J. Drago, E. J. Lee et al., “Early neonatal death in mice homozygous for a null allele of the insulin receptor gene,” Nature Genetics, vol. 12, no. 1, pp. 106–109, 1996.
- J. P. Liu, J. Baker, A. S. Perkins, E. J. Robertson, and A. Efstratiadis, “Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r),” Cell, vol. 75, no. 1, pp. 59–72, 1993.
- R. L. Joshi, B. Lamothe, N. Cordonnier et al., “Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality,” The EMBO Journal, vol. 15, no. 7, pp. 1542–1547, 1996.
- M. Holzenberger, J. Dupont, B. Ducos et al., “IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice,” Nature, vol. 421, no. 6919, pp. 182–187, 2003.
- M. Blüher, B. B. Kahn, and C. R. Kahn, “Extended longevity in mice lacking the insulin receptor in adipose tissue,” Science, vol. 299, no. 5606, pp. 572–574, 2003.
- T. Baba, T. Shimizu, Y. I. Suzuki et al., “Estrogen, insulin, and dietary signals cooperatively regulate longevity signals to enhance resistance to oxidative stress in mice,” Journal of Biological Chemistry, vol. 280, no. 16, pp. 16417–16426, 2005.
- J. Ogino, K. Sakurai, K. Yoshiwara et al., “Insulin resistance and increased pancreatic β-cell proliferation in mice expressing a mutant insulin receptor (P1195L),” Journal of Endocrinology, vol. 190, no. 3, pp. 739–747, 2006.
- Y. Matsuzawa, T. Funahashi, S. Kihara, and I. Shimomura, “Adiponectin and metabolic syndrome,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 1, pp. 29–33, 2004.
- T. Akune, S. Ohba, S. Kamekura et al., “PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors,” Journal of Clinical Investigation, vol. 113, no. 6, pp. 846–855, 2004.
- M. F. Pittenger, A. M. Mackay, S. C. Beck et al., “Multilineage potential of adult human mesenchymal stem cells,” Science, vol. 284, no. 5411, pp. 143–147, 1999.
- J. N. Beresford, J. H. Bennett, C. Devlin, P. S. Leboy, and M. E. Owen, “Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures,” Journal of Cell Science, vol. 102, no. 2, pp. 341–351, 1992.
- R. Weindruch, R. L. Walford, S. Fligiel, and D. Guthrie, “The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake,” Journal of Nutrition, vol. 116, no. 4, pp. 641–654, 1986.
- W. S. Hunter, W. B. Croson, A. Bartke, M. V. Gentry, and C. J. Meliska, “Low body temperature in long-lived Ames dwarf mice at rest and during stress,” Physiology and Behavior, vol. 67, no. 3, pp. 433–437, 1999.
- G. S. Roth, M. A. Lane, D. K. Ingram et al., “Biomarkers of caloric restriction may predict longevity in humans,” Science, vol. 297, no. 5582, p. 811, 2002.
- M. A. Lane, D. J. Baer, W. V. Rumpler et al., “Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 9, pp. 4159–4164, 1996.
- H. M. Brown-Borg, K. E. Borg, C. J. Meliska, and A. Bartke, “Dwarf mice and the ageing process,” Nature, vol. 384, no. 6604, p. 33, 1996.
- K. Flurkey, J. Papaconstantinou, R. A. Miller, and D. E. Harrison, “Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 12, pp. 6736–6741, 2001.
- H. Kurosu, M. Yamamoto, J. D. Clark et al., “Physiology: suppression of aging in mice by the hormone Klotho,” Science, vol. 309, no. 5742, pp. 1829–1833, 2005.
- A. Taguchi, L. M. Wartschow, and M. F. White, “Brain IRS2 signaling coordinates life span and nutrient homeostasis,” Science, vol. 317, no. 5836, pp. 369–372, 2007.
- C. Selman, S. Lingard, A. I. Choudhury et al., “Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice,” FASEB Journal, vol. 22, no. 3, pp. 807–818, 2008.
- C. Selman, J. M. A. Tullet, D. Wieser et al., “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span,” Science, vol. 326, no. 5949, pp. 140–144, 2009.
- T. Finkel and N. J. Holbrook, “Oxidants, oxidative stress and the biology of ageing,” Nature, vol. 408, no. 6809, pp. 239–247, 2000.
- E. Migliaccio, M. Giogio, S. Mele et al., “The adaptor protein controls oxidative stress response and life span in mammals,” Nature, vol. 402, no. 6759, pp. 309–313, 1999.
- S. I. Taylor, “Lilly lecture: molecular mechanisms of insulin resistance: lessons from patients with mutations in the insulin-receptor gene,” Diabetes, vol. 41, no. 11, pp. 1473–1490, 1992.
- S. I. Taylor, A. Cama, D. Accili et al., “Mutations in the insulin receptor gene,” Endocrine Reviews, vol. 13, no. 3, pp. 566–595, 1992.
- H. Kim, H. Kadowaki, H. Sakura et al., “Detection of mutations in the insulin receptor gene in patients with insulin resistance by analysis of single-stranded conformational polymorphisms,” Diabetologia, vol. 35, no. 3, pp. 261–266, 1992.
- A. Krook, S. Kumar, I. Laing, A. J. M. Boulton, J. A. H. Wass, and S. O'Rahilly, “Molecular scanning of the insulin receptor gene in syndromes of insulin resistance,” Diabetes, vol. 43, no. 3, pp. 357–368, 1994.
- Y. Kido, N. Philippe, A. A. Schäffer, and D. Accili, “Genetic modifiers of the insulin resistance phenotype in mice,” Diabetes, vol. 49, no. 4, pp. 589–596, 2000.
- Y. Kido, D. J. Burks, D. Withers et al., “Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2,” Journal of Clinical Investigation, vol. 105, no. 2, pp. 199–205, 2000.