Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study
Table 1
Baseline Characteristics of patients with Late Onset Depressive Symptoms (LODSs), Early Onset Depressive Symptoms (EODSs), and patients without depressive symptoms.
Depressive symptoms
Late onset
Early onset
Reference
Overall
() (20.3%)
() (21.7%)
( ) (58.0%)
() (100%)
Age yrs
71.4 (6.0)
59.1 (6.2)
65.9 (9.0)
65.6 (8.8)
Sex (male/female)
47/54
60/48
174/115
281/217
MSSE
27.4 (1.7)
28.4 (1.5)
28.3 (1.6)
28.1 (1.6)
Education (>primary school (%))
77.2%
95.4%
93.4%
90.6%
Mean CES-D
21.0 (8.0)
16.9 (11.0)
7.7 (5.0)
12.4 (9.3)
WM volume
438.4 (57.1)
484.7 (62.9)
465.3 (68.8)
464.1 (66.9)
GM volume
597.4 (66.7)
649.8 (60.5)
632.3 (65.8)
629.0 (67.1)
ICV
1660.8 (156.1)
1659.9 (146.5)
1687.9 (159.4)
1676.3 (156.3)
Median WML volume
16.8
4.5
8.0
8.0
Number of lacunar infarcts
40 (39.6%)
30 (27.8%)
101 (34.9%)
171 (34.3%)
Use of antidepressive medication
30 (29.7%)
30 (27.8%)
0 (0%)
60 (12.0%)
Number represent mean (SD) or number. MMSE: Mini Mental State Examination; CES-D: Center for Epidemiological Studies Depression Scale; WM: white matter; GM: gray matter; ICV: intracranial volume; WML: white matter lesions.
