Depressive Symptoms and Amygdala Volume in Elderly with Cerebral Small Vessel Disease: The RUN DMC Study

Table 2

Adjusted mean amygdala volume, White Matter Lesions (WMLs) volume, and lacunar infarcts in patients with Late Onset Depressive Symptoms (LODSs), Early Onset Depressive Symptoms (EODSs), and patients without depressive symptoms.

	Patients with LODS; (𝑛=101)	P-value^†	Patients with EODS; (𝑛=108)	P-value^†	Reference group; (𝑛=289)
Total amygdala volume (mL)*	3.2 (0.5)	0.05	3.5 (0.5)	0.82	3.4 (0.5)
Left amygdala (mL)*	1.6 (0.3)	0.02	1.8 (0.3)	0.71	1.8 (0.28)
Right amygdala (mL)*	1.5 (0.3)	0.43	1.7 (0.3)	0.90	1.6 (0.28)
WML volume (mL)**	21.8 (20.2)	0.06	9.5 (13.8)	0.94	14.7 (18.0)
Lacunar infarcts (%)***	32.9%	0.42	35.8%	0.47	32.0%

Number represent mean (SD) or number.
Data is shown of the comparison of LODS/EODS versus the reference group, *adjusted for age, sex, ICV, WML volume, and presence of lacunar infarcts, **adjusted for age, sex, ICV, presence of lacunar infarcts and amygdala volume, ***adjusted for age, sex, ICV, WML and amygdala volume, ^†compared with the reference group.