Insulin-Like Growth Factor I and the Pathogenesis of Delirium: A Review of Current Evidence

Table 1

Studies of IGF-I in delirium.

Authors	Settings	Design	n	Timing of IGF-I measurement	Age (mean, sd)	Baseline cognitive status	Findings
Wilson et al. [96]	Medical	Cohort	12	Baseline	84.5, 4.2	*MCI + normal	Low IGF-I risk for incident delirium
Adamis et al. [30]	Medical	Cross-sectional	22	Baseline	84.6, 6.5	50% with dementia + MCI + normal	Association of IGF-I and prevalence delirium
Lemstra et al. [97]	Orthopaedic	Case Control	18	Baseline	79.3	*MCI + normal	No association of IGF-I and delirium
Adamis et al. [98]	Medical	Longitudinal	28	Baseline and every 3 days (max 4)	84.2, 6.3	50% with dementia + MCI + normal	Association of IGF-I and all delirium
Morandi et al. [99]	ICU	Cohort	40	Day before assessment of delirium	65 (median)	No dementia	No association between IGF-I and next-day delirium

*MCI: Mild cognitive impairment.