Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders

Table 1

Age-associated changes in PGs and TxA₂ and their synthases and receptors.

Entity	Tissue	Age	Change	References
COX1/2 (hum, r, m)	Mesenteric microvessels	Adult, aged	Increase	[21, 29, 33, 34, 42, 63, 84–86]
PGI2 (hum)	Blood	Adolescent, aged	Decrease	[112, 116]
PGIS (r)	Aorta, coronary artery in heart	Adults, aged	Increase	[85, 86, 110, 120]
IP (r)	Aorta	Adults, aged	Decrease	[84, 85, 121]
PGE2 (r)	Coronary artery in heart	Aged	Increase	[120]
cPGES (r),	Aorta	Old adult	N/S	[84]
mPGES-1 (r)	Aorta	Old adult	N/S	[84]
mPGES-2 (r)	Aorta	Old adult	Increase	[84]
EP1–3 (r)	Aorta	Old adult	N/S	[84]
EP4 (r)	Aorta	Old adult	Increase	[84]
PGF2α (ham, r)	Aorta	Aged	Increase	[110, 148]
PGFS (r)	Aorta	Old adult	Increase	[84]
FP (r)	Aorta	Old adult	N/S	[84]
PGDS (r)	Aorta	Old adult	Increase	[84]
DP (r)	Aorta	Old adult	N/S	[84]
TxA2 (r)	Aorta or mesenteric artery		Increase	[42, 86, 172]
TXS (r)	Aorta	Old adult	Increase	[84]
TP (r)	Aorta	Old adult	N/S	[84]

hum: human; ham: hamster; r: rat; m: mouse; N/S: not significant.
Definition of age groups: human, adolescent, 13–19 years; adult, 20–60 years; aged, >60 years. Hamster, aged, >18 months. Rat, young adult, 3–6 months; old adult, 6–18 months; aged >24 months.