Review Article
Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders
Table 2
Prostaglandin-related pharmacological agents in the treatment of cardiovascular diseases.
| Modulator | Drugs (trade name) | Clinical application | References |
| PGI2 and its stable analogues | Epoprostenol sodium (Flolan), Beraprost sodium (Procyclin), Iloprost (Ventavis), Treprostinil (Remodulin) | Primary pulmonary hypertension, pulmonary arterial hypertension | [200–207] | PGE2 and its analogues | Dinoprostone, Viprostol | Congenital heart disease | [208–210, 214–217] | TXS inhibitors | Dazoxiben, Camonagrel, Picotamide (Dusodril) | Thrombosis, atherosclerosis, arrhythmias | [218–226] | TP inhibitors | Picotamide, S18886 (Triplion) | Thrombosis, atherosclerosis, ischemic stroke, myocardial infarction | [84, 223–227] | COX1 inhibitor | Aspirin | Thrombosis, atherosclerosis, ischemic stroke, myocardial infarction | [231–235] |
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