Table 1: Characteristics and mean scores for memory and search speed at age 60+ years, by lifestyle behaviour profiles and dichotomous covariates.

Variable 𝑁 Memory at age 60+ years 𝑃 Search speed at age 60+ years 𝑃

Smoking at age:
 36 years
  Non-smoker78025.00 (5.88)<0.001273.47 (73.13)0.002
  1–20 c/day20024.18 (6.37)266.7 (69.88)
  20+ cig/day3821.23 (7.33)233.26 (59.33)
 43 years
  Non-smoker81625.05 (5.95)<0.001274.45 (72.55)0.001
  1–20 c/day15923.99 (6.05)258.60 (68.67)
  20+ cig/day4320.72 (7.05)242.83 (73.49)
Midlife score:
 Non-smoker74425.05 (5.90)<0.001274.51 (73.69)<0.001
 Moderate smoker25224.07 (6.30)263.48 (67.50)
 Heavy smoker2220.18 (7.25)221.81 (59.74)
Change in smoking:
 Non-smoker74425.05 (5.90)0.005274.51 (73.69)0.011
 Increase5522.89 (5.91)254.63 (65.05)
 Decrease7924.77 (6.51)272.29 (60.10)
 Constant med/heavy14023.52 (6.60)255.44 (72.33)
Physical activity at age:
 36 years
  Inactive32423.82 (5.83)<0.001264.87 (72.81)0.138
  Moderate active27524.61 (5.98)270.04 (68.14)
  Most active41925.44 (6.24)275.49 (74.58)
 43 years
  Inactive47523.85 (6.13)<0.001263.83 (69.38)<0.001
  Moderate active25125.15 (6.05)267.10 (69.13)
  Most active29225.69 (5.84)284.76 (78.01)
Midlife score:
 Inactive22123.37 (6.01)<0.001259.08 (74.61)0.003
 Moderate active60824.81 (5.98)270.87 (68.78)
 Most active18925.90 (6.20)283.43 (79.00)
Change in physical activity:
 Inactive22123.37 (6.01)<0.001259.08 (74.61)0.003
 Increase16425.03 (5.35)282.39 (74.40)
 Decrease35424.61 (6.30)266.84 (66.91)
 Constant active27925.68 (6.08)277.72 (74.71)
Diet at age:
 36 years
  Low quality56424.01 (6.19)<0.001267.26 (69.12)0.096
  High quality45425.55 (5.84)274.85 (76.14)
 43 years
  Low quality52123.72 (6.13)<0.001267.24 (69.30)0.124
  High quality49725.72 (5.86)274.21 (75.41)
Midlife score:
 Low quality23422.51 (5.90)<0.001260.02 (67.96)0.010
 High quality78425.34 (5.99)273.81 (73.41)
Change in diet:
 Constant low quality23422.55 (5.90)<0.001260.02 (67.96)0.022
 Increase33025.06 (6.18)272.39 (69.57)
 Decrease9423.98 (5.44)263.80 (71.44)
 Constant high 36025.96 (5.88)277.73 (77.16)
Sex:
 Male49023.72 (5.94)<0.001265.36 (71.84)0.024
 Female52825.61 (6.07)275.54 (72.63)
Father social class
 Non-manual 50726.28 (5.90)<0.001278.69 (75.64)<0.001
 Manual51123.12 (5.84)262.66 (68.16)
Education:
 <advanced56722.77 (5.66)<0.001263.03 (70.09)<0.001
 ≥advanced45127.12 (5.71)280.21 (74.17)
Midlife social class at age:
 36 years
  Non-manual61726.24 (5.79)<0.001280.36 (71.29)<0.001
  Manual40122.33 (5.75)255.69 (71.62)
 43 years
  Non-manual69626.08 (5.79)<0.001276.31 (71.73)<0.001
  Manual32221.72 (5.60)258.38 (72.42)
Depression at age:
 43 years
  No symptoms96624.80 (6.05)0.036271.08 (72.92)0.403
  Depressive symptoms5222.98 (6.47)262.46 (61.78)
 60+ years
  No symptoms80524.85 (6.09)0.194270.03 (73.61)0.531
  Depressive symptoms17124.19 (5.74)273.87 (69.23)