Low-Dose, Ionizing Radiation and Age-Related Changes in Skeletal Microarchitecture

<table>Mouse body mass as a function of age and radiation exposure. Experiment to determine whether a single dose of <sup>137</sup>Cs gamma rays causes age-related changes in skeletal structure and bone cell differentiation. Male C57BL/6 mice (10 weeks of age, <svg height="10.9125" id="M8" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 35.099998 10.9125" width="35.099998" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">8</tspan>
</text>
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</svg>/group) were irradiated at 1, 10, and 100 cGy or were sham-irradiated (0 cGy) on day 0 and tissues harvested 1 month (inset) or 4 months after irradiation. Mean ± SD. <sup>#</sup>Denotes <svg height="11.25" id="M9" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
<g transform="translate(72,-63)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="38.559254" y="0">5</tspan>
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</svg> for changes with age (linear regression) for the respective cohorts (1 and 4 months after irradiation).</table>

Journal of Aging Research

fig1

Figure 1

Figure 1: Low-Dose, Ionizing Radiation and Age-Related Changes in Skeletal Microarchitecture 