Table 2: Adjusted associations between social engagement (independent variable) and ROI volumes (dependent variables).

ROI Mean volume (cc) Social engagement standardized coefficient value Total brain volume 1137.96 0.037 0.011 Total gray matter (GM) 534.14 0.072 0.007 Total white matter (WM) 603.82 0.001 0.975 Gray matter lobes        Frontal GM 134.85 0.037 0.273  Temporal GM 96.58 0.083 0.009  Parietal GM 65.40 0.068 0.081  Occipital GM 45.56 0.076 0.048 White matter lobes        Frontal WM 201.47 0.008 0.761  Temporal WM 119.03 0.021 0.501  Parietal WM 106.08 0.026 0.456  Occipital WM 58.22 0.007 0.869 Smaller structures        Cerebellum 119.63 −0.013 0.763  Medial structures 80.63 0.047 0.135  Cingulate gyrus 21.02 0.045 0.269  Insula 13.94 0.008 0.865  Corpus callosum 11.89 0.127 0.004  Internal capsule 9.85 0.026 0.520  Hippocampus 7.42 −0.004 0.923  Amygdala 2.43 0.037 0.453  Entorhinal cortex 2.37 −0.016 0.756

From models adjusted for age, education, intracranial volume, race/ethnicity, hypertension, diabetes, handedness, and control status. Bold: .