Table 3: Adjusted associations between change in ROI volumes (independent variable) and social engagement (dependent variable).

ROI ROI standardized coefficient1 value Total brain volume 0.023 0.713 Total gray matter (GM) 0.062 0.299 Total white matter (WM) −0.039 0.494 Gray matter lobes  Frontal GM 0.032 0.599  Temporal GM 0.112 0.055  Parietal GM 0.092 0.133  Occipital GM −0.011 0.849 White matter lobes  Frontal WM 0.010 0.851  Temporal WM 0.034  Parietal WM −0.035 0.526  Occipital WM 0.046 0.416 Other structures (GM and WM)  Cerebellum 0.022 0.695  Medial structures 0.005 0.937  Cingulate gyrus −0.023 0.696  Insula −0.014 0.803  Corpus callosum −0.019 0.730  Internal capsule 0.067 0.244  Hippocampus 0.005 0.934  Amygdala 0.050 0.368  Entorhinal cortex 0.027 0.633

From models adjusted for age, education, intracranial volume, race/ethnicity, hypertension, diabetes, handedness, and control status. 1Social engagement at time of 2nd MRI was the dependent variable. Bold: .