Table 3: Adjusted associations between change in ROI volumes (independent variable) and social engagement (dependent variable).

ROI Δ ROI standardized coefficient1 𝑃 value

Total brain volume0.0230.713
Total gray matter (GM)0.0620.299
Total white matter (WM) −0.039 0.494
Gray matter lobes
 Frontal GM 0.032 0.599
 Temporal GM 0.112 0.055
 Parietal GM 0.092 0.133
 Occipital GM −0.011 0.849
White matter lobes
 Frontal WM 0.010 0.851
Temporal WM 𝟎 . 𝟏 𝟏 𝟓 0.034
 Parietal WM −0.035 0.526
 Occipital WM 0.046 0.416
Other structures (GM and WM)
 Cerebellum 0.022 0.695
 Medial structures 0.005 0.937
 Cingulate gyrus −0.023 0.696
 Insula −0.014 0.803
 Corpus callosum −0.019 0.730
 Internal capsule 0.067 0.244
 Hippocampus 0.005 0.934
 Amygdala0.0500.368
 Entorhinal cortex0.0270.633

From models adjusted for age, education, intracranial volume, race/ethnicity, hypertension, diabetes, handedness, and control status.
1Social engagement at time of 2nd MRI was the dependent variable.
Bold: 𝑃 0 . 0 5 .