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Journal of Aging Research
Volume 2012 (2012), Article ID 806198, 8 pages
http://dx.doi.org/10.1155/2012/806198
Review Article

Aging Adults and Seasonal Influenza: Does the Vitamin D Status (H)Arm the Body?

1Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Hospital of Trois-Chêne, Chemin du Pont-Bochet 3, CH-1226 Thônex-Geneva, Switzerland
2Translational Medicine Research Group, Cranfield Health, Cranfield University, Vincent Building, College Road, Cranfield MK430AL, UK

Received 23 June 2011; Accepted 23 August 2011

Academic Editor: Monika Neuhäuser-Berthold

Copyright © 2012 Pierre Olivier Lang and Dimitrios Samaras. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. F. Holick, “Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease,” The American Journal of Clinical Nutrition, vol. 80, no. 6, supplement, pp. 1678S–1688S, 2004. View at Scopus
  2. C. J. Rosen, “Clinical practice. Vitamin D insufficiency,” The New England Journal of Medicine, vol. 364, no. 3, pp. 248–254, 2011. View at Publisher · View at Google Scholar · View at PubMed
  3. K. D. Cashman, J. M. W. Wallace, G. Horigan et al., “Estimation of the dietary requirement for vitamin D in free-living adults ≥64 y of age,” American Journal of Clinical Nutrition, vol. 89, no. 5, pp. 1366–1374, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. K. A. Kennel, M. T. Drake, and D. L. Hurley, “Vitamin D deficiency in adults: when to test and how to treat,” Mayo Clinic Proceedings, vol. 85, no. 8, pp. 752–758, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. R. Theiler, H. B. Stähelin, A. Tyndall, K. Binder, G. Somorjai, and H. A. Bischoff, “Calcidiol, calcitriol and parathyroid hormone serum concentrations in institutionalized and ambulatory elderly in Switzerland,” International Journal for Vitamin and Nutrition Research, vol. 69, no. 2, pp. 96–105, 1999. View at Scopus
  6. A. A. Ginde, J. M. Mansbach, and C. A. Camargo, “Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the third national health and nutrition examination survey,” Archives of Internal Medicine, vol. 169, no. 4, pp. 384–390, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. B. Hamilton, “Vitamin D and human skeletal muscle,” Scandinavian Journal of Medicine and Science in Sports, vol. 20, no. 2, pp. 182–190, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. N. Binkley, D. Krueger, C. S. Cowgill et al., “Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 7, pp. 3152–3157, 2004. View at Publisher · View at Google Scholar · View at PubMed
  9. N. Binkley, R. Novotny, D. Krueger et al., “Low vitamin D status despite abundant sun exposure,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 6, pp. 2130–2135, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. M. T. Hannan, H. J. Litman, A. B. Araujo et al., “Serum 25-hydroxyvitamin D and bone mineral density in a racially and ethnically diverse group of men,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 1, pp. 40–46, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. A. W. Norman, R. Bouillon, S. J. Whiting, R. Vieth, and P. Lips, “13th Workshop consensus for vitamin D nutritional guidelines,” Journal of Steroid Biochemistry and Molecular Biology, vol. 103, no. 3–5, pp. 204–205, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. P. Sanderson, R. L. Elsom, V. Kirkpatrick et al., “UK food standards agency workshop report: diet and immune function,” British Journal of Nutrition, vol. 103, no. 11, pp. 1684–1687, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. D. Bruce, J. H. Ooi, S. Yu, and M. T. Cantorna, “Vitamin D and host resistance to infection? Putting the cart in front of the horse,” Experimental Biology and Medicine, vol. 235, no. 8, pp. 921–927, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. M. Hewison, “Vitamin D and the immune system: new perspectives on an old theme,” Endocrinology and Metabolism Clinics of North America, vol. 39, no. 2, pp. 365–379, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. M. R. Haussler, G. K. Whitfield, C. A. Haussler et al., “The nuclear vitamin D receptor: biological and molecular regulatory properties revealed,” Journal of Bone and Mineral Research, vol. 13, no. 3, pp. 325–349, 1998. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. C. Mathieu and L. Adorini, “The coming of age of 1,25-dihydroxyvitamin D3 analogs as immunomodulatory agents,” Trends in Molecular Medicine, vol. 8, no. 4, pp. 174–179, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. P. O. Lang, S. Govind, J. P. Michel, R. Aspinall, and W. A. Mitchell, “Immunosenescence: implications for vaccination programmes in adults,” Maturitas, vol. 68, no. 4, pp. 322–330, 2011. View at Publisher · View at Google Scholar · View at PubMed
  18. P. O. Lang, S. Govind, W. A. Mitchell et al., “Influenza vaccine effectiveness in aged individuals: the role played by cell-mediated immunity,” European Geriatric Medicine, vol. 1, no. 4, pp. 233–238, 2010. View at Publisher · View at Google Scholar
  19. P. O. Lang, S. Govind, W. A. Mitchell, C. A. Siegrist, and R. Aspinall, “Vaccine effectiveness in older individuals: what has been learned from the influenza-vaccine experience,” Ageing Research Reviews, vol. 10, pp. 389–395, 2011. View at Publisher · View at Google Scholar · View at PubMed
  20. World Health Organization, “Influenza vaccines,” The Weekly Epidemiological Record, vol. 80, pp. 279–287, 2005.
  21. A. S. Monto, F. Ansaldi, R. Aspinall et al., “Influenza control in the 21st century: optimizing protection of older adults,” Vaccine, vol. 27, no. 37, pp. 5043–5053, 2009. View at Publisher · View at Google Scholar · View at PubMed
  22. J. E. McElhaney and R. B. Effros, “Immunosenescence: what does it mean to health outcomes in older adults?” Current Opinion in Immunology, vol. 21, no. 4, pp. 418–424, 2009. View at Publisher · View at Google Scholar · View at PubMed
  23. N. A. M. Molinari, I. R. Ortega-Sanchez, M. L. Messonnier et al., “The annual impact of seasonal influenza in the US: measuring disease burden and costs,” Vaccine, vol. 25, no. 27, pp. 5086–5096, 2007. View at Publisher · View at Google Scholar · View at PubMed
  24. J. M. Alonso, “Immunity and pathophysiology of respiratory tract infections,” Medecine et Maladies Infectieuses, vol. 38, no. 8, pp. 433–437, 2008. View at Publisher · View at Google Scholar · View at PubMed
  25. G. Diamond, D. Legarda, and L. K. Ryan, “The innate immune response of the respiratory epithelium,” Immunological Reviews, vol. 173, pp. 27–38, 2000. View at Publisher · View at Google Scholar
  26. J. C. Ho, K. N. Chan, W. H. Hu et al., “The effect of aging on nasal mucociliary clearance, beat frequency, and ultrastructure of respiratory cilia,” American Journal of Respiratory and Critical Care Medicine, vol. 163, no. 4, pp. 983–988, 2001.
  27. M. Svartengren, R. Falk, and K. Philipson, “Long-term clearance from small airways decreases with age,” European Respiratory Journal, vol. 26, no. 4, pp. 609–615, 2005. View at Publisher · View at Google Scholar · View at PubMed
  28. R. J. Knudson, D. F. Clark, T. C. Kennedy, and D. E. Knudson, “Effect of aging alone on mechanical properties of the normal adult human lung,” Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, vol. 43, no. 6, pp. 1054–1062, 1977.
  29. A. S. Buchman, P. A. Boyle, R. S. Wilson, L. Gu, J. L. Bienias, and D. A. Bennett, “Pulmonary function, muscle strength and mortality in old age,” Mechanisms of Ageing and Development, vol. 129, no. 11, pp. 625–631, 2008. View at Publisher · View at Google Scholar · View at PubMed
  30. D. M. Newnham and S. J. C. Hamilton, “Sensitivity of the cough reflex in young and elderly subjects,” Age and Ageing, vol. 26, no. 3, pp. 185–188, 1997. View at Publisher · View at Google Scholar
  31. R. H. Alford, J. A. Kasel, P. J. Gerone, and V. Knight, “Human influenza resulting from aerosol inhalation,” Proceedings of the Society for Experimental Biology and Medicine, vol. 122, no. 3, pp. 800–804, 1966.
  32. H. J. Schunemann, J. Dorn, B. J. B. Grant, W. Winkelstein, and M. Trevisan, “Pulmonary function is a long-term predictor of mortality in the general population: 29-Year follow-up of the Buffalo Health Study,” Chest, vol. 118, no. 3, pp. 656–664, 2000.
  33. K. C. Meyer, N. S. Rosenthal, P. Soergel, and K. Peterson, “Neutrophils and low-grade inflammation in the seemingly normal aging human lung,” Mechanisms of Ageing and Development, vol. 104, no. 2, pp. 169–181, 1998. View at Publisher · View at Google Scholar
  34. A. Panda, F. Qian, S. Mohanty et al., “Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response,” Journal of Immunology, vol. 184, no. 5, pp. 2518–2527, 2010. View at Publisher · View at Google Scholar · View at PubMed
  35. T. R. Traynor, J. A. Majde, S. G. Bohnet, and J. M. Krueger, “Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus,” Brain, Behavior, and Immunity, vol. 21, no. 3, pp. 311–322, 2007. View at Publisher · View at Google Scholar · View at PubMed
  36. D. C. Norman, “Fever in the elderly,” Clinical Infectious Diseases, vol. 31, no. 1, pp. 148–151, 2000. View at Publisher · View at Google Scholar · View at PubMed
  37. B. Weinberger, D. Herndler-Brandstetter, A. Schwanninger, D. Weiskopf, and B. Grubeck-Loebenstein, “Biology of immune responses to vaccines in elderly persons,” Clinical Infectious Diseases, vol. 46, no. 7, pp. 1078–1084, 2008. View at Publisher · View at Google Scholar · View at PubMed
  38. P. O. Lang, W. A. Mitchell, A. Lapenna, D. Pitts, and R. Aspinall, “Immunological pathogenesis of main age-related diseases and frailty: role of immunosenescence,” European Geriatric Medicine, vol. 1, no. 2, pp. 112–121, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. D. Weiskopf, B. Weinberger, and B. Grubeck-Loebenstein, “The aging of the immune system,” Transplant International, vol. 22, no. 11, pp. 1041–1050, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. H. W. Virgin, E. J. Wherry, and R. Ahmed, “Redefining chronic viral infection,” Cell, vol. 138, no. 1, pp. 30–50, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  41. T. Fulop, A. Larbi, N. Douziech et al., “Signal transduction and functional changes in neutrophils with aging,” Aging Cell, vol. 3, no. 4, pp. 217–226, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  42. T. Fulop, A. Larbi, A. Wikby, E. Mocchegiani, K. Hirokawa, and G. Pawelec, “Dysregulation of T-cell function in the elderly: scientific basis and clinical implications,” Drugs and Aging, vol. 22, no. 7, pp. 589–603, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. S. Govind, A. Lapenna, P. O. Lang, and R. Aspinall, “Immunotherapy of immunosenescence: who, how and when,” Open Longevity Science. In press.
  44. R. Aspinall, D. Pitts, A. Lapenna, and W. Mitchell, “Immunity in the elderly: the role of the thymus,” Journal of Comparative Pathology, vol. 142, no. 1, pp. S111–S115, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  45. T. Fulop, A. Larbi, J. M. Witkowski et al., “Aging, frailty and age-related diseases,” Biogerontology, vol. 11, no. 5, pp. 547–563, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  46. T. Fulop, G. Pawelec, S. Castle, and M. Loeb, “Immunosenescence and vaccination in nursing home residents,” Clinical Infectious Diseases, vol. 48, no. 4, pp. 443–448, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  47. B. Lesourd, “Nutritional factors and immunological ageing,” Proceedings of the Nutrition Society, vol. 65, no. 3, pp. 319–325, 2006. View at Publisher · View at Google Scholar · View at Scopus
  48. W. Savino and M. Dardenne, “Nutritional imbalances and infections affect the thymus: consequences on T-cell-mediated immune responses,” Proceedings of the Nutrition Society, vol. 69, pp. 636–643, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  49. J. C. O'Connor, R. H. McCusker, K. Strle, R. W. Johnson, R. Dantzer, and K. W. Kelley, “Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology,” Cellular Immunology, vol. 252, no. 1-2, pp. 91–110, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  50. K. W. Kelley, D. A. Weigent, and R. Kooijman, “Protein hormones and immunity,” Brain, Behavior, and Immunity, vol. 21, no. 4, pp. 384–392, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  51. V. Parodi, D. De Florentiis, M. Martini, and F. Ansaldi, “Inactivated influenza vaccines: recent progress and implications for the elderly,” Drugs and Aging, vol. 28, no. 2, pp. 93–106, 2011. View at Publisher · View at Google Scholar · View at PubMed
  52. P. O. Lang and R. Aspinall, “Immunosenescence and herd immunity: with an ever increasing aging population do we need to rethink vaccine schedules?” Expert Review of Vaccines. In press.
  53. M. K. Chadha, M. Fakih, J. Muindi et al., “Effect of 25-hydroxyvitamin D status on serological response to influenza vaccine in prostate cancer patients,” Prostate, vol. 71, no. 4, pp. 368–372, 2011. View at Publisher · View at Google Scholar · View at PubMed
  54. J. D. Kriesel and J. Spruance, “Calcitriol (1,25-dihydroxy-vitamin D3) coadministered with influenza vaccine does not enhance humoral immunity in human volunteers,” Vaccine, vol. 17, no. 15-16, pp. 1883–1888, 1999. View at Publisher · View at Google Scholar · View at Scopus
  55. R. F. Edlich, S. S. Mason, J. J. Dahlstrom, E. Swainston, W. B. Long Iii, and K. D. Gubler, “Pandemic preparedness for swine flu influenza in the united states,” Journal of Environmental Pathology, Toxicology and Oncology, vol. 28, no. 4, pp. 261–264, 2009.
  56. M. R. Goldstein, L. Mascitelli, and F. Pezzetta, “Pandemic influenza A (H1N1): mandatory vitamin D supplementation?” Medical Hypotheses, vol. 74, no. 4, p. 756, 2010. View at Publisher · View at Google Scholar · View at PubMed
  57. M. T. Abreu, Y. Kantorovich, E. A. Vasiliauskas et al., “Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density,” Gut, vol. 53, no. 8, pp. 1129–1136, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  58. M. Hewison, F. Burke, K. N. Evans et al., “Extra-renal 25-hydroxyvitamin D3-1α-hydroxylase in human health and disease,” Journal of Steroid Biochemistry and Molecular Biology, vol. 103, no. 3–5, pp. 316–321, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  59. N. Liu, L. Nguyen, R. F. Chun et al., “Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation,” Endocrinology, vol. 149, no. 10, pp. 4799–4808, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  60. E. Kállay, G. Bises, E. Bajna et al., “Colon-specific regulation of vitamin D hydroxylases—A possible approach for tumor prevention,” Carcinogenesis, vol. 26, no. 9, pp. 1581–1589, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  61. J. J. Cannell, R. Vieth, J. C. Umhau et al., “Epidemic influenza and vitamin D,” Epidemiology and Infection, vol. 134, no. 6, pp. 1129–1140, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  62. P. T. Liu, S. Stenger, H. Li et al., “Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response,” Science, vol. 311, no. 5768, pp. 1770–1773, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  63. C. Wejse, V. F. Gomes, P. Rabna et al., “Vitamin D as supplementary treatment for tuberculosis: a double-blind, randomized, placebo-controlled trial,” American Journal of Respiratory and Critical Care Medicine, vol. 179, no. 9, pp. 843–850, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  64. L. Gao, Y. Tao, L. Zhang, and Q. Jin, “Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and meta-analysis,” International Journal of Tuberculosis and Lung Disease, vol. 14, no. 1, pp. 15–23, 2010. View at Scopus
  65. A. I. Christopoulos, A. A. Diamantopoulos, P. A. Dimopoulos, D. S. Goumenos, and G. A. Barbalias, “Risk factors for tuberculosis in dialysis patients: a prospective multi-center clinical trial,” BMC Nephrology, vol. 10, no. 1, article 36, 2009. View at Publisher · View at Google Scholar · View at PubMed
  66. J. S. Adams and M. Hewison, “Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity,” Nature Clinical Practice Endocrinology and Metabolism, vol. 4, no. 2, pp. 80–90, 2008. View at Publisher · View at Google Scholar · View at PubMed
  67. A. F. Gombart, N. Borregaard, and H. P. Koeffler, “Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3,” FASEB Journal, vol. 19, no. 9, pp. 1067–1077, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  68. P. T. Liu, S. Stenger, D. H. Tang, and R. L. Modlin, “Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin,” Journal of Immunology, vol. 179, no. 4, pp. 2060–2063, 2007. View at Scopus
  69. H. Reichel, H. P. Koeffler, J. E. Bishop, and A. W. Norman, “25-Hydroxyvitamin D3 metabolism by lipopolysaccharide-stimulated normal human macrophages,” Journal of Clinical Endocrinology and Metabolism, vol. 64, no. 1, pp. 1–9, 1987. View at Scopus
  70. E. Y. Enioutina, D. Bareyan, and R. A. Daynes, “TLR-induced local metabolism of vitamin D3 plays an important role in the diversification of adaptive immune responses,” Journal of Immunology, vol. 182, no. 7, pp. 4296–4305, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  71. T. T. Wang, F. P. Nestel, V. Bourdeau et al., “Cutting edge: 1,25-Dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression,” Journal of Immunology, vol. 173, no. 5, pp. 2909–2912, 2004. View at Scopus
  72. S. Yim, P. Dhawan, C. Ragunath, S. Christakos, and G. Diamond, “Induction of cathelicidin in normal and CF bronchial epithelial cells by 1,25-dihydroxyvitamin D3,” Journal of Cystic Fibrosis, vol. 6, no. 6, pp. 403–410, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  73. G. Weber, J. D. Heilborn, C. I. C. Jimenez, A. Hammarsjö, H. Törmä, and M. Ståhle, “Vitamin D induces the antimicrobial protein hCAP18 in human skin,” Journal of Investigative Dermatology, vol. 124, no. 5, pp. 1080–1082, 2005. View at Publisher · View at Google Scholar · View at PubMed
  74. E. Leikina, H. Delanoe-Ayari, K. Melikov et al., “Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins,” Nature Immunology, vol. 6, no. 10, pp. 995–1001, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  75. G. Penna and L. Adorini, “1α,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation,” Journal of Immunology, vol. 164, no. 5, pp. 2405–2411, 2000. View at Scopus
  76. A. G. S. Van Halteren, E. Van Etten, E. C. De Jong, R. Bouillon, B. O. Roep, and C. Mathieu, “Redirection of human autoreactive T-cells upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D3,” Diabetes, vol. 51, no. 7, pp. 2119–2125, 2002. View at Scopus
  77. D. D'Ambrosio, M. Cippitelli, M. G. Cocciolo et al., “Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-κB downregulation in transcriptional repression of the p40 gene,” Journal of Clinical Investigation, vol. 101, no. 1, pp. 252–262, 1998. View at Scopus
  78. A. Boonstra, F. J. Barrat, C. Crain, V. L. Heath, H. F. J. Savelkoul, and A. O'Garra, “1α,25-Dihydroxyvitamin D3 has a direct effect on naive CD4+ T cells to enhance the development of Th2 cells,” Journal of Immunology, vol. 167, no. 9, pp. 4974–4980, 2001. View at Scopus
  79. M. Cippitelli, C. Fionda, D. Di Bona et al., “Negative regulation of CD95 ligand gene expression by vitamin D3 in T lymphocytes,” Journal of Immunology, vol. 168, no. 3, pp. 1154–1166, 2002. View at Scopus
  80. S. Chen, G. P. Sims, X. C. Xiao, Y. G. Yue, S. Chen, and P. E. Lipsky, “Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation,” Journal of Immunology, vol. 179, no. 3, pp. 1634–1647, 2007. View at Scopus
  81. J. M. Lemire, J. S. Adams, R. Sakai, and S. C. Jordan, “1α,25-Dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells,” Journal of Clinical Investigation, vol. 74, no. 2, pp. 657–661, 1984. View at Scopus
  82. F. J. Barrat, D. J. Cua, A. Boonstra et al., “In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines,” Journal of Experimental Medicine, vol. 195, no. 5, pp. 603–616, 2002. View at Publisher · View at Google Scholar · View at Scopus
  83. S. Gorman, L. A. Kuritzky, M. A. Judge et al., “Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodes,” Journal of Immunology, vol. 179, no. 9, pp. 6273–6283, 2007. View at Scopus
  84. S. Gregori, N. Giarratana, S. Smiroldo, M. Uskokovic, and L. Adorini, “A 1α,25-dihydroxyvitamin D3 analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice,” Diabetes, vol. 51, no. 5, pp. 1367–1374, 2002. View at Scopus
  85. Z. Urry, E. Xystrakis, D. F. Richards et al., “Ligation of TLR9 induced on human IL-10-secreting Tregs by 1α,25-dihydroxyvitamin D3 abrogates regulatory function,” Journal of Clinical Investigation, vol. 119, no. 2, pp. 387–398, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  86. R. A. Daynes, B. A. Araneo, J. Hennebold, E. Enioutina, and H. H. Mu, “Steroids as regulators of the mammalian immune response,” Journal of Investigative Dermatology, vol. 105, no. 1, supplement, pp. 14S–19S, 1995.
  87. D. L. Trump, M. K. Chadha, A. Y. Sunga et al., “Vitamin D deficiency and insufficiency among patients with prostate cancer,” British Journal of Urology International, vol. 104, no. 7, pp. 909–914, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  88. M. Urashima, T. Segawa, M. Okazaki, M. Kurihara, Y. Wada, and H. Ida, “Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren,” American Journal of Clinical Nutrition, vol. 91, no. 5, pp. 1255–1260, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus