Review Article
Aging and Osteoarthritis: An Inevitable Encounter?
Table 1
Age-related mechanisms triggering OA.
| Mechanism | Consequence |
| Oxidative stress | Cell senescence | Apoptosis/autophagy | Reduced regeneration capacity | Matrix protein modification (e.g., glycosylation) | Reduced elasticity, fluid content, stability | Nonenzymatic collagen cross-linking | Impaired crack-bridging potency | Sarcopenia | Reduced joint stability | Loss of proprioception | Microtrauma, Charcot-like arthropathy | Joint laxity | Microtrauma | Synovitis | Inflammatory cytokine production | Increased osteon density | Bone stiffness | Reduced circulating progenitor cells (e.g., MSC) | Impaired regeneration capacity |
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