Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced by β Amyloid

Figure 1

Mitochondrial impairments following 𝐴𝛽_1--42 and letrozole treatment. (a) Representative 3D reconstructions of MitoTracker Deep Red-positive mitochondria from hippocampal dendritic segments treated with letrozole (1 μM) for 72 hours. Scale bar 5 μm. (b) Quantifications of mitochondrial volumes. Significant differences in mitochondrial volume relative to control (4.03±0.56 μm³) were observed for letrozole (1.72±0.49 μm³, 𝑃=0.015) and indicated by an asterix (*).

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