Figure 1: Mitochondrial impairments following and letrozole treatment. (a) Representative 3D reconstructions of MitoTracker Deep Red-positive mitochondria from hippocampal dendritic segments treated with letrozole (1 μM) for 72 hours. Scale bar 5 μm. (b) Quantifications of mitochondrial volumes. Significant differences in mitochondrial volume relative to control ( μm3) were observed for letrozole ( μm3, ) and indicated by an asterix (*).