538979.fig.006a
(a)
538979.fig.006b
(b)
Figure 6: Summarising schematic: aromatase inhibition leads to synaptic and mitochondrial deficits. (a) Aromatase-mediated conversion of testosterone to estrogen in astrocytes serves as a local reservoir of neuroestrogens to promote maintenance of dendritic spines and synaptic mitochondrial integrity. (b) Aromatase inhibition by letrozole leads to spine loss, pre- and postsynaptic protein deficits, and compromised mitochondrial integrity.