- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Annual Issues
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Journal of Aging Research
Volume 2013 (2013), Article ID 538979, 11 pages
Letrozole Potentiates Mitochondrial and Dendritic Spine Impairments Induced by β Amyloid
Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, Canada H3G 1Y6
Received 5 March 2013; Accepted 18 June 2013
Academic Editor: Holly M. Brown-Borg
Copyright © 2013 P. K.-Y. Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- V. F. Semiglazov, V. V. Semiglazov, G. A. Dashyan et al., “Phase 2 randomized trial of primary endocrine therapy versus chemotherapy in postmenopausal patients with estrogen receptor-positive breast cancer,” Cancer, vol. 110, no. 2, pp. 244–254, 2007.
- J. V. A. Choate and J. A. Resko, “Paradoxical effect of an aromatase inhibitor, CGS 20267, on aromatase activity in guinea pig brain,” Journal of Steroid Biochemistry and Molecular Biology, vol. 58, no. 4, pp. 411–415, 1996.
- B. P. Haynes, M. Dowsett, W. R. Miller, J. M. Dixon, and A. S. Bhatnagar, “The pharmacology of letrozole,” Journal of Steroid Biochemistry and Molecular Biology, vol. 87, no. 1, pp. 35–45, 2003.
- V. Shilling, V. Jenkins, L. Fallowfield, and T. Howell, “The effects of hormone therapy on cognition in breast cancer,” Journal of Steroid Biochemistry and Molecular Biology, vol. 86, no. 3-5, pp. 405–412, 2003.
- P. Penzes, M. E. Cahill, K. A. Jones, J.-E. Vanleeuwen, and K. M. Woolfrey, “Dendritic spine pathology in neuropsychiatric disorders,” Nature Neuroscience, vol. 14, no. 3, pp. 285–293, 2011.
- M. V. Sofroniew and H. V. Vinters, “Astrocytes: biology and pathology,” Acta Neuropathologica, vol. 119, no. 1, pp. 7–35, 2010.
- J. Prange-Kiel, L. Fester, L. Zhou, H. Jarry, and G. M. Rune, “Estrus cyclicity of spinogenesis: underlying mechanisms,” Journal of Neural Transmission, vol. 116, no. 11, pp. 1417–1425, 2009.
- R. Vierk, G. Glassmeier, L. Zhou, et al., “Aromatase inhibition abolishes LTP generation in female but not in male mice,” The Journal of Neuroscience, vol. 32, no. 24, pp. 8116–8126, 2012.
- P. Polo-Kantola, R. Portin, O. Polo, H. Helenius, K. Irjala, and R. Erkkola, “The effect of short-term estrogen replacement therapy on cognition: a randomized, double-blind, cross-over trial in postmenopausal women,” Obstetrics and Gynecology, vol. 91, no. 3, pp. 459–466, 1998.
- E. Hogervorst, J. Williams, M. Budge, W. Riedel, and J. Jolles, “The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women: a meta-analysis,” Neuroscience, vol. 101, no. 3, pp. 485–512, 2000.
- O. T. Wolf, B. M. Kudielka, D. H. Hellhammer, S. Törber, B. S. McEwen, and C. Kirschbaum, “Two weeks of transdermal estradiol treatment in postmenopausal elderly women and its effect on memory and mood: verbal memory changes are associated with the treatment induced estradiol levels,” Psychoneuroendocrinology, vol. 24, no. 7, pp. 727–741, 1999.
- T. Duka, R. Tasker, and J. F. McGowan, “The effects of 3-week estrogen hormone replacement on cognition in elderly healthy females,” Psychopharmacology, vol. 149, no. 2, pp. 129–139, 2000.
- A. Kugaya, C. N. Epperson, S. Zoghbi et al., “Increase in prefrontal cortex serotonin2A receptors following estrogen treatment in postmenopausal women,” American Journal of Psychiatry, vol. 160, no. 8, pp. 1522–1524, 2003.
- V. W. Henderson, “Action of estrogens in the aging brain: dementia and cognitive aging,” Biochimica et Biophysica Acta, vol. 1800, no. 10, pp. 1077–1083, 2010.
- D. Caruso, A. M. Barron, M. A. Brown, et al., “Age-related changes in neuroactive steroid levels in 3xTg-AD mice,” Neurobiol Aging, vol. 34, pp. 1080–1089, 2013.
- C. R. Overk, P.-Y. Lu, Y.-T. Wang et al., “Effects of aromatase inhibition versus gonadectomy on hippocampal complex amyloid pathology in triple transgenic mice,” Neurobiology of Disease, vol. 45, no. 1, pp. 479–487, 2012.
- J. C. Carroll, E. R. Rosario, L. Chang et al., “Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice,” Journal of Neuroscience, vol. 27, no. 48, pp. 13357–13365, 2007.
- W. Wei, L. N. Nguyen, H. W. Kessels, H. Hagiwara, S. Sisodia, and R. Malinow, “Amyloid beta from axons and dendrites reduces local spine number and plasticity,” Nature Neuroscience, vol. 13, no. 2, pp. 190–196, 2010.
- S. Boridy, H. Takahashi, K. Akiyoshi, and D. Maysinger, “The binding of pullulan modified cholesteryl nanogels to Aβ oligomers and their suppression of cytotoxicity,” Biomaterials, vol. 30, no. 29, pp. 5583–5591, 2009.
- H. Hsieh, J. Boehm, C. Sato et al., “AMPAR removal underlies Aβ-induced synaptic depression and dendritic spine loss,” Neuron, vol. 52, no. 5, pp. 831–843, 2006.
- V. De Paola, S. Arber, and P. Caroni, “AMPA receptors regulate dynamic equilibrium of presynaptic terminals in mature hippocampal networks,” Nature Neuroscience, vol. 6, no. 5, pp. 491–500, 2003.
- B. H. Gähwiler, M. Capogna, D. Debanne, R. A. McKinney, and S. M. Thompson, “Organotypic slice cultures: a technique has come of age,” Trends in Neurosciences, vol. 20, no. 10, pp. 471–477, 1997.
- R. A. McKinney, M. Capogna, R. Dürr, B. H. Gähwiler, and S. M. Thompson, “Miniature synaptic events maintain dendritic spines via AMPA receptor activation,” Nature Neuroscience, vol. 2, no. 1, pp. 44–49, 1999.
- P. Mendez, L. M. Garcia-Segura, and D. Muller, “Estradiol promotes spine growth and synapse formation without affecting pre-established networks,” Hippocampus, vol. 21, no. 12, pp. 1263–1267, 2011.
- A. Grimm, Y. A. Lim, A. G. Mensah-Nyagan, J. Gotz, and A. Eckert, “Alzheimer's disease, oestrogen and mitochondria: an ambiguous relationship,” Molecular Neurobiology, vol. 46, pp. 151–160, 2012.
- J. W. Simpkins, K. D. Yi, S.-H. Yang, and J. A. Dykens, “Mitochondrial mechanisms of estrogen neuroprotection,” Biochimica et Biophysica Acta, vol. 1800, no. 10, pp. 1113–1120, 2010.
- M. Matsuzaki, G. C. R. Ellis-Davies, T. Nemoto, Y. Miyashita, M. Iino, and H. Kasai, “Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons,” Nature Neuroscience, vol. 4, no. 11, pp. 1086–1092, 2001.
- J. M. Mateos, A. Lüthi, N. Savic et al., “Synaptic modifications at the CA3-CA1 synapse after chronic AMPA receptor blockade in rat hippocampal slices,” Journal of Physiology, vol. 581, no. 1, pp. 129–138, 2007.
- L. Fester, L. Zhou, C. Voets et al., “The opposing roles of estradiol on synaptic protein expression in hippocampal cultures,” Psychoneuroendocrinology, vol. 34, supplement 1, pp. S123–S129, 2009.
- A. Vlachos, E. Korkotian, E. Schonfeld, E. Copanaki, T. Deller, and M. Segal, “Synaptopodin regulates plasticity of dendritic spines in hippocampal neurons,” Journal of Neuroscience, vol. 29, no. 4, pp. 1017–1033, 2009.
- S. C. Janicki and N. Schupf, “Hormonal influences on cognition and risk for Alzheimer's disease,” Current Neurology and Neuroscience Reports, vol. 10, no. 5, pp. 359–366, 2010.
- A. Prat, M. Behrendt, E. Marcinkiewicz, et al., “A novel mouse model of Alzheimer's disease with chronic estrogen deficiency leads to glial cell activation and hypertrophy,” Journal of Aging Research, vol. 2011, Article ID 251517, 12 pages, 2011.
- J. L. Furman, D. M. Sama, J. C. Gant, et al., “Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease,” The Journal of Neuroscience, vol. 32, pp. 16129–16140, 2012.
- F. Liu, M. Day, L. C. Muñiz et al., “Activation of estrogen receptor-β regulates hippocampal synaptic plasticity and improves memory,” Nature Neuroscience, vol. 11, no. 3, pp. 334–343, 2008.
- H. Du, L. Guo, S. Yan, A. A. Sosunov, G. M. McKhann, and S. S. Yan, “Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 43, pp. 18670–18675, 2010.
- S. J. Baloyannis, “Mitochondria are related to synaptic pathology in Alzheimer's disease,” International Journal of Alzheimer's Disease, Article ID 305395, 2011.
- J. Y. Sung, O. Engmann, M. A. Teylan, A. C. Nairn, P. Greengard, and Y. Kim, “WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 8, pp. 3112–3116, 2008.
- R. J. Youle and A. M. van der Bliek, “Mitochondrial fission, fusion, and stress,” Science, vol. 337, pp. 1062–1065, 2012.
- Y. Rui, J. Gu, K. Yu, H. C. Hartzell, and J. Q. Zheng, “Inhibition of AMPA receptor trafficking at hippocampal synapses by -amyloid oligomers: the mitochondrial contribution,” Molecular Brain, vol. 3, no. 1, article 10, 2010.
- X. Zhu, G. Perry, M. A. Smith, and X. Wang, “Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease,” Journal of Alzheimer's Disease, vol. 33, pp. S253–S262, 2013.
- E. Trushina, E. Nemutlu, S. Zhang et al., “Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial alzheimer's disease,” PLoS ONE, vol. 7, no. 2, Article ID e32737, 2012.
- B. Westermann, “Nitric oxide links mitochondrial fission to alzheimer's disease,” Science Signaling, vol. 2, no. 69, p. pe29, 2009.