- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Annual Issues
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Journal of Aging Research
Volume 2013 (2013), Article ID 861893, 10 pages
Physical Activity Improves Verbal and Spatial Memory in Older Adults with Probable Mild Cognitive Impairment: A 6-Month Randomized Controlled Trial
1Department of Psychology, University of British Columbia (UBC), 2136 West Mall, Vancouver, BC, Canada V6T 1Z4
2Department of Physical Therapy, University of British Columbia (UBC), 212-2177 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
3Alzheimer Clinic, G37 Purdy Pavilion, UBC Hospital, University of British Columbia (UBC), 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
4Brain Research Centre, University of British Columbia (UBC), 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
5Department of Psychology, The University of Iowa, E11 Seashore Hall, Iowa City, IA 52242-1409, USA
Received 1 November 2012; Accepted 18 January 2013
Academic Editor: Louis Bherer
Copyright © 2013 Lindsay S. Nagamatsu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- C. P. Ferri, M. Prince, C. Brayne et al., “Global prevalence of dementia: a Delphi consensus study,” The Lancet, vol. 366, no. 9503, pp. 2112–2117, 2005.
- R. Brookmeyer, E. Johnson, K. Ziegler-Graham, and H. M. Arrighi, “Forecasting the global burden of Alzheimer's disease,” Alzheimer's and Dementia, vol. 3, no. 3, pp. 186–191, 2007.
- R. C. Petersen, R. Doody, A. Kurz et al., “Current concepts in mild cognitive impairment,” Archives of Neurology, vol. 58, no. 12, pp. 1985–1992, 2001.
- A. Busse, J. Bischkopf, S. G. Riedel-Heller, and M. C. Angermeyer, “Mild cognitive impairment: prevalence and incidence according to different diagnostic criteria. Results of the Leipzig Longitudinal Study of the Aged (LEILA75+),” British Journal of Psychiatry, vol. 182, pp. 449–454, 2003.
- R. C. Petersen, G. E. Smith, S. C. Waring, R. J. Ivnik, and E. Kokmen, “Mild cognitive impairment: clinical characterization and outcome,” Archives of Neurology, vol. 56, no. 3, pp. 303–308, 1999.
- T. Liu-Ambrose, L. S. Nagamatsu, P. Graf, B. L. Beattie, M. C. Ashe, and T. C. Handy, “Resistance training and executive functions: a 12-month randomized controlled trial,” Archives of Internal Medicine, vol. 170, no. 2, pp. 170–178, 2010.
- T. Liu-Ambrose, L. S. Nagamatsu, M. W. Voss, K. M. Khan, and T. C. Handy, “Resistance training and functional plasticity of the aging brain: a 12-month randomized controlled trial,” Neurobiology of Aging, vol. 33, no. 8, pp. 1690–1698, 2011.
- S. J. Colcombe, A. F. Kramer, K. I. Erickson et al., “Cardiovascular fitness, cortical plasticity, and aging,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 9, pp. 3316–3321, 2004.
- N. T. Lautenschlager, K. L. Cox, L. Flicker et al., “Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial,” Journal of the American Medical Association, vol. 300, no. 9, pp. 1027–1037, 2008.
- L. D. Baker, L. L. Frank, K. Foster-Schubert et al., “Effects of aerobic exercise on mild cognitive impairment: a controlled trial,” Archives of Neurology, vol. 67, no. 1, pp. 71–79, 2010.
- L. S. Nagamatsu, T. C. Handy, C. L. Hsu, and T. Liu-Ambrose, “Resistance training promotes cognitive and functional brain plasticity in seniors with probable mild cognitive impairment,” Archives of Internal Medicine, vol. 172, no. 8, pp. 666–668, 2012.
- J. C. Smith, K. A. Nielson, J. L. Woodard et al., “Does physical activity influence semantic memory activation in amnestic mild cognitive impairment?” Psychiatry Research, vol. 193, no. 1, pp. 60–62, 2011.
- R. C. Cassilhas, K. S. Lee, J. Fernandes et al., “Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms,” Neuroscience, vol. 202, pp. 309–317, 2012.
- S. Colcombe and A. F. Kramer, “Fitness effects on the cognitive function of older adults: a meta-analytic study,” Psychological Science, vol. 14, no. 2, pp. 125–130, 2003.
- Z. S. Nasreddine, N. A. Phillips, V. Bédirian et al., “The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment,” Journal of the American Geriatrics Society, vol. 53, no. 4, pp. 695–699, 2005.
- M. P. Lawton and E. M. Brody, “Assessment of older people: self-maintaining and instrumental activities of daily living,” Gerontologist, vol. 9, no. 3, pp. 179–186, 1969.
- R. A. Washburn, E. McAuley, J. Katula, S. L. Mihalko, and R. A. Boileau, “The Physical Activity Scale for the Elderly (PASE): evidence for validity,” Journal of Clinical Epidemiology, vol. 52, no. 7, pp. 643–651, 1999.
- J. A. Yesavage, “Geriatric depression scale,” Psychopharmacology Bulletin, vol. 24, no. 4, pp. 709–710, 1988.
- D. L. Groll, T. To, C. Bombardier, and J. G. Wright, “The development of a comorbidity index with physical function as the outcome,” Journal of Clinical Epidemiology, vol. 58, no. 6, pp. 595–602, 2005.
- M. D. Lezak, Neuropsychological Assessment, Oxford University Press, New York, NY, USA, 3rd edition, 1995.
- K. I. Erickson, M. W. Voss, R. S. Prakash et al., “Exercise training increases size of hippocampus and improves memory,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 7, pp. 3017–3022, 2011.
- M. W. Voss, K. I. Erickson, R. S. Prakash et al., “Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition?” Neuropsychologia, vol. 48, no. 5, pp. 1394–1406, 2010.
- K. I. Erickson, R. S. Prakash, M. W. Voss et al., “Aerobic fitness is associated with hippocampal volume in elderly humans,” Hippocampus, vol. 19, no. 10, pp. 1030–1039, 2009.
- S. Heo, R. S. Prakash, M. W. Voss et al., “Resting hippocampal blood flow, spatial memory and aging,” Brain Research, vol. 1315, pp. 119–127, 2010.
- T. Liu-Ambrose, K. M. Khan, J. J. Eng, P. A. Janssen, S. R. Lord, and H. A. McKay, “Resistance and agility training reduce fall risk in women aged 75 to 85 with low bone mass: a 6-month randomized, controlled trial,” Journal of the American Geriatrics Society, vol. 52, no. 5, pp. 657–665, 2004.
- G. Borg, “Ratings of perceived exertion and heart rates during short-term cycle exercise and their use in a new cycling srength test,” International Journal of Sports Medicine, vol. 3, no. 3, pp. 153–158, 1982.
- R. Persinger, C. Foster, M. Gibson, D. C. W. Fater, and J. P. Porcari, “Consistency of the Talk Test for exercise prescription,” Medicine and Science in Sports and Exercise, vol. 36, no. 9, pp. 1632–1636, 2004.
- C. Foster, J. P. Porcari, J. Anderson et al., “The talk test as a marker of exercise training intensity,” Journal of Cardiopulmonary Rehabilitation and Prevention, vol. 28, no. 1, pp. 24–30, 2008.
- ICH Expert Working Group, “ICH Harmonised Tripartite Guideline: statistical principals in clinical trials,” Statistics in Medicine, vol. 18, pp. 1905–1942, 1999.
- A. C. Pereira, D. E. Huddleston, A. M. Brickman et al., “An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 13, pp. 5638–5643, 2007.
- P. M. Greenwood, T. Sunderland, C. Lambert, and R. Parasuraman, “Effects of apolipoprotein E genotype on spatial attention, working memory, and their interaction in healthy, middle-aged adults: results from the National Institute of Mental Health's BIOCARD study,” Neuropsychology, vol. 19, no. 2, pp. 199–211, 2005.
- M. L. Smith and B. Milner, “The role of the right hippocampus in the recall of spatial location,” Neuropsychologia, vol. 19, no. 6, pp. 781–793, 1981.
- I. J. Rhyu, J. A. Bytheway, S. J. Kohler et al., “Effects of aerobic exercise training on cognitive function and cortical vascularity in monkeys,” Neuroscience, vol. 167, no. 4, pp. 1239–1248, 2010.
- A. Parachikova, K. E. Nichol, and C. W. Cotman, “Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition,” Neurobiology of Disease, vol. 30, no. 1, pp. 121–129, 2008.
- E. V. Cyarto, N. T. Lautenschlager, P. M. Desmond et al., “Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: the AIBL Active trial,” BMC Psychiatry, vol. 12, article 167, 2012.