Association of Leukocyte Telomere Length with Fatigue in Nondisabled Older Adults
Table 2
The association between covariates and, respectively, LTL, and fatigue.
Covariates
Association with LTL
Association fatigue
Raw
Adjusted (sex, age)
Raw
Adjusted (sex, age)
Coef†
CI (95%)
Coef†
CI (95%)
Coef†
CI (95%)
Coef†
CI (95%)
Fatigue (Score 0–6)
0.039
0.006–0.071
0.019
0.038 ††
0.005–0.070
0.023
Age
−0.019
−0.035–−0.003
0.018
−0.20
−0.036–−0.004
0.012
−0.041
−0.073–−0.009
0.012
−0.040
−0.072–−0.008
0.014
Sex
Male
Ref
Ref
Ref
Ref
Female
0.161
0.032–0.290
0.014
0.169
0.041–0.297
0.009
−0.169
−0.426–0.088
0.197
−0.154
−0.408–0.099
0.233
Zygosity
MZ
Ref
Ref
Ref
Ref
DZ
−0.027
−0.150–0.097
0.672
−0.039
−0.159–0.081
0.530
−0.020
−0.263–0.223
0.871
−0.047
−0.286–0.192
0.700
Geleffect
0.007
0.000–0.014
0.040
0.002
−0.008–0.011
0.688
Smoking
Never
Ref
Ref
Ref
Ref
Former
−0.076
−0.172–0.021
0.124
−0.063
−0.160–0.035
0.206
−0.132
−0.408–0.144
0.349
−0.208
−0.490–0.074
0.148
Current
−0.127
−0.234–−0.020
0.020
−0.122
−0.230–−0.014
0.027
−0.156
−0.448–0.135
0.293
−0.252
−0.547–0.043
0.095
Physical activity (Score 0–4)
0.024
−0.006–0.054
0.122
0.020
−0.011–0.049
0.213
0.344
0.266–0.423
<0.001
0.336
0.257–0.415
<0.001
BMI
−0.010
−0.022–0.003
0.137
−0.010
−0.023–0.003
0.127
−0.039
−0.072–−0.006
0.019
−0.052
−0.085–−0.018
0.002
Cognitive function
0.014
−0.000–0.027
0.053
0.011
−0.009–0.025
0.111
0.041
0.005–0.077
0.025
0.038
0.002–0.074
0.037
Depression symptomatology
−0.012
−0.022–−0.002
0.022
−0.012
−0.022–−0.002
0.024
−0.120
−0.145–−0.094
<0.001
−0.118
−0.143–−0.093
<0.001
Cancer
No
Ref
Ref
Ref
Ref
Yes
−0.005
−0.122–0.113
0.940
−0.010
−0.127–0.107
0.868
−0.230
−0.588–0.129
0.209
−0.236
−0.592–0.120
0.194
CVD
No
Ref
Ref
Ref
Ref
Yes
−0.009
0.095–0.076
0.829
−0.013
−0.098–0.072
0.763
−0.173
−0.414–0.068
0.160
−0.167
−0.406–0.072
0.171
Diabetes
No
Ref
Ref
Ref
Ref
Yes
0.001
−0.191–0.192
0.997
0.006
−0.184–0.196
0.952
−0.297
−0.852–0.257
0.293
−0.266
−0.817–0.284
0.343
Rheumatic
No
Ref
Ref
Ref
Ref
Yes
0.004
−0.080–0.087
0.933
−0.011
−0.095–0.072
0.788
−0.414
−0.656–−0.179
0.001
−0.419
−0.659–−0.179
<0.001
Bold values mark the significant adjusted coeffients. †The coefficients shows the magnitude of the linear association between covariates and LTL respectively fatigue. First columns are raw data, while second columns are adjusted for sex and age. ††There is a significant association between LTL and fatigue when adjusting for age and sex. The coefficient of 0.038 tells that for every increase on the fatigue score (i.e. the less fatigued) the LTL is 0.038 kb longer.
