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Journal of Aging Research
Volume 2014 (2014), Article ID 475093, 6 pages
http://dx.doi.org/10.1155/2014/475093
Research Article

White Blood Cell Count in Elderly Is Clinically Useful in Predicting Long-Term Survival

1Centre for Clinical Research, Västmanland County Hospital, Uppsala University, 721 89 Västerås, Sweden
2Department of Clinical Physiology, Västmanland County Hospital, 721 89 Västerås, Sweden
3Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden

Received 28 June 2013; Accepted 11 November 2013; Published 29 January 2014

Academic Editor: Astrid E. Fletcher

Copyright © 2014 Göran Nilsson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. White blood cell (WBC) count is often included in routine clinical checkups. We determined the prognostic impact of WBC count on all-cause, cardiovascular, and noncardiovascular mortality during an 11-year followup in a general population of 75-year-olds. Study Population. The study included 207 men and 220 women comprising 69% of the invited 75-year-olds in a defined geographical area. Main Results. The median WBC count (in 109/L) was 6.3 (interquartile range 5.4–7.2) for men and 5.7 (4.9–6.8) for women, for sex difference. The hazard ratio (HR) for all-cause mortality per 109/L increase in WBCs was 1.16 (95% confidence interval, 1.03–1.32; ) in men and 1.28 (1.10–1.50; ) in women. These HRs were essentially unchanged by adjustment for established risk factors (current smoking, known hypertension, prior myocardial infarction, known diabetes, total cholesterol, high-density lipoprotein cholesterol, and body mass index). Furthermore, increased WBC count was significantly associated with cardiovascular mortality in both sexes and with noncardiovascular mortality in women. Conclusions. The WBC count deserves attention as a potentially clinical useful predictor of survival in the 75-year-olds, especially among women.