About this Journal Submit a Manuscript Table of Contents
Journal of Aging Research
Volume 2014 (2014), Article ID 475093, 6 pages
http://dx.doi.org/10.1155/2014/475093
Research Article

White Blood Cell Count in Elderly Is Clinically Useful in Predicting Long-Term Survival

1Centre for Clinical Research, Västmanland County Hospital, Uppsala University, 721 89 Västerås, Sweden
2Department of Clinical Physiology, Västmanland County Hospital, 721 89 Västerås, Sweden
3Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden

Received 28 June 2013; Accepted 11 November 2013; Published 29 January 2014

Academic Editor: Astrid E. Fletcher

Copyright © 2014 Göran Nilsson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. F. Gillum, D. D. Ingram, and D. M. Makuc, “White blood cell count, coronary heart disease, and death: the NHANES I epidemiologic follow-up study,” American Heart Journal, vol. 125, no. 3, pp. 855–863, 1993. View at Publisher · View at Google Scholar · View at Scopus
  2. M. P. Weijenberg, E. J. M. Feskens, and D. Kromhout, “White blood cell count and the risk of coronary heart disease and all-cause mortality in elderly men,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 16, no. 4, pp. 499–503, 1996. View at Scopus
  3. C. Ruggiero, E. J. Metter, A. Cherubini et al., “White blood cell count and mortality in the Baltimore Longitudinal Study of Aging,” Journal of the American College of Cardiology, vol. 49, no. 18, pp. 1841–1850, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. S. T. Weiss, M. R. Segal, D. Sparrow, and C. Wager, “Relation of FEV1 and peripheral blood leukocyte count to total mortality. The Normative Aging Study,” American Journal of Epidemiology, vol. 142, no. 5, pp. 493–503, 1995. View at Scopus
  5. T. P. Erlinger, P. Muntner, and K. J. Helzlsouer, “WBC count and the risk of cancer mortality in a national sample of U.S. adults: results from the Second National Health and Nutrition Examination Survey mortality study,” Cancer Epidemiology Biomarkers and Prevention, vol. 13, no. 6, pp. 1052–1056, 2004. View at Scopus
  6. K. L. Margolis, R. J. Rodabough, C. A. Thomson, A. M. Lopez, and A. McTiernan, “Prospective study of leukocyte count as a predictor of incident breast, colorectal, endometrial, and lung cancer and mortality in postmenopausal women,” Archives of Internal Medicine, vol. 167, no. 17, pp. 1837–1844, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. D. W. Brown, E. S. Ford, W. H. Giles, J. B. Croft, L. S. Balluz, and A. H. Mokdad, “Associations between white blood cell count and risk for cerebrovascular disease mortality: NHANES II Mortality Study, 1976—1992,” Annals of Epidemiology, vol. 14, no. 6, pp. 425–430, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. J. M. Willems, S. Trompet, G. J. Blauw, R. G. J. Westendorp, and A. J. M. de Craen, “White blood cell count and c-reactive protein are independent predictors of mortality in the oldest old,” Journals of Gerontology A, vol. 65, no. 7, pp. 764–768, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Nilsson, P. Hedberg, and J. Ohrvik, “Inflammation and the metabolic syndrome: clustering and impact on survival in a Swedish community-based cohort of 75 year olds,” Metabolic Syndrome and Related Disorders, vol. 11, no. 2, pp. 92–101, 2013. View at Publisher · View at Google Scholar
  10. W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, “Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge,” Clinical Chemistry, vol. 18, no. 6, pp. 499–502, 1972. View at Scopus
  11. “Age- and sex-specific prevalences of diabetes and impaired glucose regulation in 13 European cohorts,” Diabetes Care, vol. 26, no. 1, pp. 61–69, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Nilsson, J. Ohrvik, I. Lonnberg, and P. Hedberg, “Ten-year survival in 75-year-old men and women: predictive ability of total cholesterol, HDL-C, and LDL-C,” Current Gerontology and Geriatrics Research, vol. 2009, Article ID 158425, 7 pages, 2009. View at Publisher · View at Google Scholar
  13. G. Nilsson, P. Hedberg, T. Jonason, I. Lönnberg, Å. Tenerz, and J. Öhrvik, “White blood cell counts associate more strongly to the metabolic syndrome in 75-year-old women than in men: a population based study,” Metabolic Syndrome and Related Disorders, vol. 5, no. 4, pp. 359–364, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. R. H. Grimm Jr., J. D. Neaton, and W. Ludwig, “Prognostic importance of the white blood cell count for coronary, cancer, and all-cause mortality,” Journal of the American Medical Association, vol. 254, no. 14, pp. 1932–1937, 1985. View at Publisher · View at Google Scholar · View at Scopus
  15. K. L. Margolis, J. E. Manson, P. Greenland et al., “Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women's Health Initiative Observational Study,” Archives of Internal Medicine, vol. 165, no. 5, pp. 500–508, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. J. G. Wheeler, M. E. Mussolino, R. F. Gillum, and J. Danesh, “Associations between differential leucocyte count and incident coronary heart disease: 1764 Incident cases from seven prospective studies of 30,374 individuals,” European Heart Journal, vol. 25, no. 15, pp. 1287–1292, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. C. K.-W. Cheng, J. Chan, G. S. Cembrowski, and O. W. van Assendelft, “Complete blood count reference interval diagrams derived from NHANES III: stratification by age, sex, and race,” Laboratory Hematology, vol. 10, no. 1, pp. 42–53, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. F. Corre, J. Lellouch, and D. Schwartz, “Smoking and leucocyte-counts. Results of an epidemiological survey,” The Lancet, vol. 2, no. 7725, pp. 632–634, 1971. View at Scopus
  19. R. W. Alexander, “Inflammation and coronary artery disease,” The New England Journal of Medicine, vol. 331, no. 7, pp. 468–469, 1994. View at Publisher · View at Google Scholar · View at Scopus
  20. E. Gkrania-Klotsas, Z. Ye, A. J. Cooper et al., “Differential white blood cell count and type 2 diabetes: systematic review and meta-analysis of cross-sectional and prospective studies,” PLoS ONE, vol. 5, no. 10, Article ID e13405, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. D. W. Ross, L. H. Ayscue, J. Watson, and S. A. Bentley, “Stability of hematologic parameters in healthy subjects. Intraindividual versus interindividual variation,” American Journal of Clinical Pathology, vol. 90, no. 3, pp. 262–267, 1988. View at Scopus