Journal of Aging Research http://www.hindawi.com The latest articles from Hindawi Publishing Corporation © 2015 , Hindawi Publishing Corporation . All rights reserved. Genetic Risk Score Predicts Late-Life Cognitive Impairment Sun, 23 Aug 2015 09:13:28 +0000 http://www.hindawi.com/journals/jar/2015/267062/ Introduction. A family history of Alzheimer’s disease is a significant risk factor for its onset, but the genetic risk associated with possessing multiple risk alleles is still poorly understood. Methods. In a sample of 95 older adults (Mean age = 75.1, 64.2% female), we constructed a genetic risk score based on the accumulation of risk alleles in BDNF, COMT, and APOE. A neuropsychological evaluation and consensus determined cognitive status (44 nonimpaired, 51 impaired). Logistic regression was performed to determine whether the genetic risk score predicted cognitive impairment above and beyond that associated with each gene. Results. An increased genetic risk score was associated with a nearly 4-fold increased risk of cognitive impairment (OR = 3.824, = .013) when including the individual gene polymorphisms as covariates in the model. Discussion. A risk score combining multiple genetic influences may be more useful in predicting late-life cognitive impairment than individual polymorphisms. Mariegold E. Wollam, Andrea M. Weinstein, Judith A. Saxton, Lisa Morrow, Beth Snitz, Nicole R. Fowler, Barbara L. Suever Erickson, Kathryn A. Roecklein, and Kirk I. Erickson Copyright © 2015 Mariegold E. Wollam et al. All rights reserved. Active and Healthy Ageing and Independent Living Thu, 06 Aug 2015 08:37:30 +0000 http://www.hindawi.com/journals/jar/2015/542183/ Maddalena Illario, Miriam Vollenbroek-Hutten, David William Molloy, Enrica Menditto, Guido Iaccarino, and Patrik Eklund Copyright © 2015 Maddalena Illario et al. All rights reserved. Sarcopenia Is Associated with High Pulse Pressure in Older Women Wed, 05 Aug 2015 14:36:24 +0000 http://www.hindawi.com/journals/jar/2015/109824/ Introduction. Sarcopenia is a geriatric syndrome associated with impairment of muscle function, metabolism, and cognition in older women. Recent studies have shown a relationship between changes in muscle mass and the cardiovascular system. However, this relationship has not been fully elucidated. Methods. One hundred and thirty community-dwelling Brazilian older women (65.4 ± 6.3 years) were recruited to participate in this study. Data on body composition (via bioelectrical impedance measurements), cardiovascular parameters (using an automatic and noninvasive monitor), and muscle function (using a 3-meter gait speed test) were measured. Results. Sarcopenic older women () presented higher levels of pulse pressure (PP) (60.3 ± 2.6 mmHg) and lower muscle function (0.5 ± 0.0 m/s) compared with nonsarcopenic subjects () (53.7 ± 1.5 mmHg; 0.9 ± 0.0 m/s) (). Linear regression analysis demonstrated a significantly negative association between skeletal muscle index (SMI) and PP levels (, ). Furthermore, sarcopenic older women showed a 3.1-fold increased risk of having higher PP levels compared with nonsarcopenic women (IC = 1.323–7.506) (). Conclusion. Sarcopenic older women showed lower muscle function and higher cardiovascular risk due to increased PP levels compared with nonsarcopenic subjects. Hélio José Coelho Júnior, Samuel da Silva Aguiar, Ivan de Oliveira Gonçalves, Ricardo Aurélio Carvalho Sampaio, Marco Carlos Uchida, Milton Rocha Moraes, and Ricardo Yukio Asano Copyright © 2015 Hélio José Coelho Júnior et al. All rights reserved. Self-Assessment of Adherence to Medication: A Case Study in Campania Region Community-Dwelling Population Wed, 05 Aug 2015 14:18:28 +0000 http://www.hindawi.com/journals/jar/2015/682503/ Objectives. The aim of the study was to assess self-reported medication adherence measure in patients selected during a health education and health promotion focused event held in the Campania region. The study also assessed sociodemographic determinants of adherence. Methods. An interviewer assisted survey was conducted to assess adherence using the Italian version of the 8-item Morisky Medication Adherence Scale (MMAS-8). Participants older than 18 years were interviewed by pharmacists while waiting for free-medical checkup. Results. A total of 312 participants were interviewed during the Health Campus event. A total of 187 (59.9%) had low adherence to medications. Pearson’s bivariate correlation showed positive association between the MMAS-8 score and gender, educational level and smoking (). A multivariable analysis showed that the level of education and smoking were independent predictors of adherence. Individuals with an average level of education (odds ratio (OR), 2.21, 95% confidence interval (CI), 1.08–4.52) and nonsmoker (odds ratio (OR) 1.87, 95% confidence interval (CI), 1.04–3.35) were found to be more adherent to medication than those with a lower level of education and smoking. Conclusion. The analysis showed very low prescription adherence levels in the interviewed population. The level of education was a relevant predictor associated with that result. Enrica Menditto, Francesca Guerriero, Valentina Orlando, Catherine Crola, Carolina Di Somma, Maddalena Illario, Donald E. Morisky, and Annamaria Colao Copyright © 2015 Enrica Menditto et al. All rights reserved. Active Aging: Exploration into Self-Ratings of “Being Active,” Out-of-Home Physical Activity, and Participation among Older Australian Adults Living in Four Different Settings Wed, 05 Aug 2015 13:34:06 +0000 http://www.hindawi.com/journals/jar/2015/501823/ We examined whether self-ratings of “being active” among older people living in four different settings (major city high and lower density suburbs, a regional city, and a rural area) were associated with out-of-home participation and outdoor physical activity. A mixed-methods approach (survey, travel diary, and GPS tracking over a one-week period) was used to gather data from 48 individuals aged over 55 years. Self-ratings of “being active” were found to be positively correlated with the number of days older people spent time away from home but unrelated to time traveled by active means (walking and biking). No significant differences in active travel were found between the four study locations, despite differences in their respective built environments. The findings suggest that additional strategies to the creation of “age-friendly” environments are needed if older people are to increase their levels of outdoor physical activity. “Active aging” promotion campaigns may need to explicitly identify the benefits of walking outdoors to ambulatory older people as a means of maintaining their overall health, functional ability, and participation within society in the long-term and also encourage the development of community-based programs in order to facilitate regular walking for this group. Rosemary L. Aird and Laurie Buys Copyright © 2015 Rosemary L. Aird and Laurie Buys. All rights reserved. Leisure Engagement: Medical Conditions, Mobility Difficulties, and Activity Limitations—A Later Life Perspective Wed, 05 Aug 2015 12:44:51 +0000 http://www.hindawi.com/journals/jar/2015/610154/ Objectives. This study aims to investigate the impact of medical conditions, mobility difficulties, and activity limitations on older people’s engagement in leisure activities. Methods. The analyses are based on a cross regional survey carried out in 2010 in the Bothnia region (Northern Sweden and Western Finland). A posted questionnaire, which included questions on different aspects of leisure engagement, medical history, and health, was sent out to older persons in the region. The final sample consisted of 5435 persons aged 65, 70, 75, and 80 years. The data was analyzed by using ordinary least squares (OLS) multivariate regression. Results. The most important predictor of leisure engagement abstention among older people is the prevalence of activity limitations, whereas mobility difficulties and medical conditions play less important roles. The strong negative association between activity limitations and leisure engagement remains significant even after we control for individual, sociodemographic characteristics, and country. Discussion. This study provides a window into leisure engagement in later life and factors influencing the magnitude of engagement in leisure activities. Ingeborg Nilsson, Fredrica Nyqvist, Yngve Gustafson, and Mikael Nygård Copyright © 2015 Ingeborg Nilsson et al. All rights reserved. Functional Fitness and Self-Reported Quality of Life of Older Women Diagnosed with Knee Osteoarthrosis: A Cross-Sectional Case Control Study Wed, 05 Aug 2015 10:30:06 +0000 http://www.hindawi.com/journals/jar/2015/841985/ Aim. Utilizing a cross-sectional case control design, the aim of this study was to evaluate the functional fitness and self-reported quality of life differences in older people diagnosed with knee osteoarthrosis (O) who participated in health promotion groups. Methods. Ninety older women were distributed into two groups: control without O of the knee (C, ) and a group diagnosed with primary and secondary knee O with grade II or higher, with definite osteophytes (OA, ). Functional fitness was evaluated by specific tests, and the time spent in physical activity and quality of life was evaluated by the IPAQ and WHOQOL (distributed in four domains: physical: P, psychological: PS, social: S, and environmental: E) domain questionnaires. Results. No differences were found between ages of groups (C: ; OA: ; years). The values of the chair stand test (rep) in the OA () group were different when compared to C group (). For the 6-minute walk test (meters), the values obtained for the C () were higher () than the OA () group. The time spent in physical activity (min) was greater () in the control () group compared to OA () group. Higher values () in all domains were found in the C (P: , PS: , S: , E: ) group compared to OA (P: , PS: , S: , E: ) group. Conclusion. Our data suggests that knee O, in older women, can promote a decline in time spent performing physical activity and functional fitness with decline in quality of life with an increase in sitting time. Paula Andréa Malveira Cavalcante, Márcio Roberto Doro, Frank Shiguemitsu Suzuki, Roberta Luksevicius Rica, Andrey Jorge Serra, Francisco Luciano Pontes Junior, Alexandre Lopes Evangelista, Aylton José Figueira Junior, Julien Steven Baker, and Danilo Sales Bocalini Copyright © 2015 Paula Andréa Malveira Cavalcante et al. All rights reserved. A Community-Based, Technology-Supported Health Service for Detecting and Preventing Frailty among Older Adults: A Participatory Design Development Process Wed, 05 Aug 2015 10:28:09 +0000 http://www.hindawi.com/journals/jar/2015/216084/ Frailty is a multifaceted condition that affects many older adults and marks decline on areas such as cognition, physical condition, and nutritional status. Frail individuals are at increased risk for the development of disability, dementia, and falls. There are hardly any health services that enable the identification of prefrail individuals and that focus on prevention of further functional decline. In this paper, we discuss the development of a community-based, technology-supported health service for detecting prefrailty and preventing frailty and further functional decline via participatory design with a wide range of stakeholders. The result is an innovative service model in which an online platform supports the integration of traditional services with novel, Information Communication Technology supported tools. This service is capable of supporting the different phases of screening and offers training services, by also integrating them with community-based services. The service model can be used as a basis for developing similar services within a wide range of healthcare systems. We present the service model, the general functioning of the technology platform, and the different ways in which screening for and prevention of frailty has been localized. Finally, we reflect on the added value of participatory design for creating such health services. Lex van Velsen, Maddalena Illario, Stephanie Jansen-Kosterink, Catherine Crola, Carolina Di Somma, Annamaria Colao, and Miriam Vollenbroek-Hutten Copyright © 2015 Lex van Velsen et al. All rights reserved. Picture Your Nursing Home: Exploring the Sense of Home of Older Residents through Photography Wed, 05 Aug 2015 10:27:18 +0000 http://www.hindawi.com/journals/jar/2015/312931/ The quality of the built environment can impact the quality of life and the sense of home of nursing home residents. This study investigated (1) which factors in the physical and social environment correlate with the sense of home of the residents and (2) which environmental factors are most meaningful. Twelve participants engaged in a qualitative study, in which photography was as a supportive tool for subsequent interviews. The data were analysed based on the six phases by Braun and Clarke. The four themes identified are (1) the physical view; (2) mobility and accessibility; (3) space, place, and personal belongings; and (4) the social environment and activities. A holistic understanding of which features of the built environment are appreciated by the residents can lead to the design and retrofitting of nursing homes that are more in line with personal wishes. J. van Hoof, M. M. Verhagen, E. J. M. Wouters, H. R. Marston, M. D. Rijnaard, and B. M. Janssen Copyright © 2015 J. van Hoof et al. All rights reserved. Is Self-Reported Physical Activity Participation Associated with Lower Health Services Utilization among Older Adults? Cross-Sectional Evidence from the Canadian Community Health Survey Wed, 05 Aug 2015 10:21:23 +0000 http://www.hindawi.com/journals/jar/2015/425354/ Purpose. To examine relationships between leisure time physical activity (LTPA) and health services utilization (H) in a nationally representative sample of community-dwelling older adults. Methods. Cross-sectional data from 56,652 Canadian Community Health Survey respondents aged ≥ 50 years (48% M; 52% F; mean age 63.5 ± 10.2 years) were stratified into three age groups and analysed using multivariate generalized linear modeling techniques. Participants were classified according to PA level based on self-reported daily energy expenditure. Nonleisure PA (NLPA) was categorized into four levels ranging from mostly sitting to mostly lifting objects. Results. Active 50–65-year-old individuals were 27% less likely to report any GP consultations and had 8% fewer GP consultations annually than their inactive peers. Active persons aged 65–79 years were 18% less likely than inactive respondents to have been hospitalized overnight in the previous year . Higher levels of NLPA were significantly associated with lower levels of HSU, across all age groups. Conclusion. Nonleisure PA appeared to be a stronger predictor of all types of HSU, particularly in the two oldest age groups. Considering strategies that focus on reducing time spent in sedentary activities may have a positive impact on reducing the demand for health services. Koren L. Fisher, Elizabeth L. Harrison, Bruce A. Reeder, Nazmi Sari, and Karen E. Chad Copyright © 2015 Koren L. Fisher et al. All rights reserved. Falls Reduction and Exercise Training in an Assisted Living Population Wed, 05 Aug 2015 09:35:58 +0000 http://www.hindawi.com/journals/jar/2015/957598/ Multicomponent exercise programs are currently an efficacious fall prevention strategy among community dwelling older adults although research documents differential falls susceptibility among frail older adults. This study aimed to examine the association between the Boston FICSIT (Frailty and Injuries: Cooperative Studies of Intervention Techniques) exercise program (the original exercise program to demonstrate that nursing home residents can increase strength) and falls incidents in an assisted living community. A descriptive cross-sectional study matched exercise charts for frequency and duration of training with number of reported fall incidents. Among 39 participants, 33% () reported a fall incident. Adults without a fall history reported more time in aerobic (26.30 versus 20.00, P value ) and strength (1.50 versus 0.50, P value ) training sessions compared to those with a fall history. Multivariate models adjusting for covariates illustrated a significant protective association between strength training and fall incidents (; 95% , 0.85). In this cross-sectional study, this progressive resistance exercise training program into an assisted living population was associated with a decrease in the number of fall incidents. Kimberly J. Alvarez, Shannen Kirchner, Serena Chu, Sarah Smith, Wendy Winnick-Baskin, and Thelma J. Mielenz Copyright © 2015 Kimberly J. Alvarez et al. All rights reserved. Which Part of a Short, Global Risk Assessment, the Risk Instrument for Screening in the Community, Predicts Adverse Healthcare Outcomes? Wed, 05 Aug 2015 09:02:16 +0000 http://www.hindawi.com/journals/jar/2015/256414/ The Risk Instrument for Screening in the Community (RISC) is a short, global risk assessment to identify community-dwelling older adults’ one-year risk of institutionalisation, hospitalisation, and death. We investigated the contribution that the three components of the RISC (concern, its severity, and the ability of the caregiver network to manage concern) make to the accuracy of the instrument, across its three domains (mental state, activities of daily living (ADL), and medical state), by comparing their accuracy to other assessment instruments in the prospective Community Assessment of Risk and Treatment Strategies study. RISC scores were available for 782 patients. Across all three domains each subtest more accurately predicted institutionalisation compared to hospitalisation or death. The caregiver network’s ability to manage ADL more accurately predicted institutionalisation (AUC 0.68) compared to hospitalisation (AUC 0.57, ) or death (AUC 0.59, ), comparing favourably with the Barthel Index (AUC 0.67). The severity of ADL (AUC 0.63), medical state (AUC 0.62), Clinical Frailty Scale (AUC 0.67), and Charlson Comorbidity Index (AUC 0.66) scores had similar accuracy in predicting mortality. Risk of hospitalisation was difficult to predict. Thus, each component, and particularly the caregiver network, had reasonable accuracy in predicting institutionalisation. No subtest or assessment instrument accurately predicted risk of hospitalisation. Rónán O’Caoimh, Carol FitzGerald, Una Cronin, Anton Svendrovski, Yang Gao, Elizabeth Healy, Elizabeth O’Connell, Gabrielle O’Keeffe, Eileen O’Herlihy, Elizabeth Weathers, Nicola Cornally, Patricia Leahy-Warren, Francesc Orfila, Constança Paúl, Roger Clarnette, and D. William Molloy Copyright © 2015 Rónán O’Caoimh et al. All rights reserved. Variations in Community Prevalence and Determinants of Recreational and Utilitarian Walking in Older Age Mon, 03 Aug 2015 13:56:02 +0000 http://www.hindawi.com/journals/jar/2015/382703/ Background. Regular walking is critical to maintaining health in older age. We examined influences of individual and community factors on walking habits in older adults. Methods. We analyzed walking habits among participants of a prospective cohort study of 745 community-dwelling men and women, mainly aged 70 years or older. We estimated community variations in utilitarian and recreational walking, and examined whether the variations were attributable to community differences in individual and environmental factors. Results. Prevalence of recreational walking was relatively uniform while prevalence of utilitarian walking varied across the 16 communities in the study area. Both types of walking were associated with individual health and physical abilities. However, utilitarian walking was also strongly associated with several measures of neighborhood socioeconomic status and access to amenities while recreational walking was not. Conclusions. Utilitarian walking is strongly influenced by neighborhood environment, but intrinsic factors may be more important for recreational walking. Communities with the highest overall walking prevalence were those with the most utilitarian walkers. Public health promotion of regular walking should take this into account. Elizabeth Procter-Gray, Suzanne G. Leveille, Marian T. Hannan, Jie Cheng, Kevin Kane, and Wenjun Li Copyright © 2015 Elizabeth Procter-Gray et al. All rights reserved. Health Status and Health Determinants of Older Immigrant Women in Canada: A Scoping Review Mon, 27 Jul 2015 06:12:45 +0000 http://www.hindawi.com/journals/jar/2015/393761/ Increasing international migration in the context of aging populations makes a comprehensive understanding of older immigrant women’s health status and determinants of their health particularly urgent. Using Arksey and O’Malley’s framework, we conducted a scoping review to examine the available literature on the health of older immigrant women in Canada. We searched CINAHL, PsycINFO, Embase, Medline, and Cochrane databases for the period of 1990 to 2014 for Canadian-based, peer-reviewed studies on the topic. A total of 20 articles met the inclusion criteria. These articles were divided into six areas of focus: physical health; mental health; abuse; health promotion and chronic disease prevention; barriers to healthcare access and utilization; and health beliefs, behaviours, and practices. Our results show that the health of older immigrant women is affected by the interplay of various social determinants of health including the physical and social environment; economic conditions; cultural beliefs; gendered norms; and the healthcare delivery system. Our results also revealed that older immigrant women tend to have more health problems, underutilize preventive services, such as cancer screening, and experience more difficulties in accessing healthcare services. Sepali Guruge, Birpreet Birpreet, and Joan A. Samuels-Dennis Copyright © 2015 Sepali Guruge et al. All rights reserved. Cumulative Weight Exposure Is Associated with Different Weight Loss Strategies and Weight Loss Success in Adults Age 50 or Above Thu, 28 May 2015 14:10:58 +0000 http://www.hindawi.com/journals/jar/2015/904798/ Objectives. To evaluate if cumulative weight exposure is associated with weight loss strategy choices and weight loss success. Methods. Data from the National Health and Nutrition Examination Survey were used; a total of 4,562 people age 50 years or older who reported trying to lose weight in the last year were studied. Cumulative weight exposure (CWE) score was defined as the sum of body mass index points above 25 kg/m2 at the age of 25, 10 years ago, 1 year ago, and now. Weight loss strategies were self-reported and weight loss success was defined as reaching a 5% weight loss in the last year. Results. Chosen strategies for weight loss vary across tertiles of CWE. Participants in the highest CWE tertile were about 4 to 20 times more likely to lose at least 5% of body weight in the past year compared to those in the lowest CWE tertile ().  Discussion. Strategies used to lose weight and weight loss success using different weight loss strategies vary considerably across cumulative weight exposure. Thus, cumulative weight exposure might be a variable worth considering when intervening with this population. Martin Sénéchal, Jana Slaght, and Danielle R. Bouchard Copyright © 2015 Martin Sénéchal et al. All rights reserved. Intramuscular Olanzapine in the Management of Behavioral and Psychological Symptoms in Hospitalized Older Adults: A Retrospective Descriptive Study Sun, 24 May 2015 11:30:57 +0000 http://www.hindawi.com/journals/jar/2015/570410/ Background. While behavioral and psychological symptoms are frequent in hospitalized older adults with dementia or delirium, data supporting the off-label use of intramuscular atypical antipsychotics remain scarce. We examined the use of short-acting intramuscular (IM) olanzapine in hospitalized older adults to manage behavioral and psychological symptoms. Methods. A retrospective observational study of inpatients 65 years or older with at least one order for olanzapine IM during admission in urban Ontario Canada was conducted. Patient demographics, prescriptions for olanzapine IM, reason for administration, perceived effectiveness, adverse events, concurrently prescribed psychotropics, comorbidities, and patient discharge destination were recorded. Results. Among 82 patients aged 65–96 years (mean ± SD 79.3 ± 7.7) 85 cases were identified. Cognitive impairment or dementia affected 63.5% and 50.6% had comorbidities. Olanzapine IM was ordered 102 times and 34 patients (41%) received at least one dose. The intended efficacy was achieved in 79.4% of 78 cases of 124 doses given (62.9%). Fourteen (41%) patients who received doses experienced adverse events, with sedation and hypotension being the most common. Conclusions. Olanzapine IM appears effective in hospitalized older adults but is associated with potential adverse events. Structured monitoring and documentation are needed to ensure safe use in this high-risk population. Silvia Duong, Kam-Tong Yeung, and Feng Chang Copyright © 2015 Silvia Duong et al. All rights reserved. An Open-Label Trial of Memantine for Cognitive Impairment in Patients with Posttraumatic Stress Disorder Tue, 12 May 2015 09:09:01 +0000 http://www.hindawi.com/journals/jar/2015/934162/ Background. Studies using standard neuropsychological instruments have demonstrated memory deficits in patients with PTSD. We evaluated the efficacy and safety of the N-methyl-D-aspartate antagonist memantine in veterans with PTSD and cognitive impairment. Methods. Twenty-six veterans with PTSD and cognitive impairment received 16 weeks of memantine in an open-label fashion. Cognition was assessed using the Spatial Span, Logical Memory I, and Letter-Number Sequencing subtests of the Wechsler Memory Scale III and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). RBANS measures attention, language, visuospatial skills, and immediate and delayed memories. The Clinician Administered PTSD Scale (CAPS), Hamilton Depression Scale (HAM-D), Hamilton Anxiety Scale (HAM-A), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), and Sheehan Disability Scale (SDS) were secondary outcome measures. Results. There was a significant improvement in RBANS, both total and subscale scores (), over time. There was a reduction in total CAPS scores, avoidance/numbing symptoms (CAPS-C) and hyperarousal symptoms (CAPS-D), HAM-D, Q-LES-Q, and SDS scores. However, there was no reduction in reexperiencing (CAPS-B) and HAM-A scores. Memantine was well tolerated. Conclusions. Memantine improved cognitive symptoms, PTSD symptoms, and mood in veterans with PTSD. Randomized double-blind studies are needed to validate these preliminary observations. Sriram Ramaswamy, Jayakrishna Madabushi, John Hunziker, Subhash C. Bhatia, and Frederick Petty Copyright © 2015 Sriram Ramaswamy et al. All rights reserved. Older Primary Care Patients’ Attitudes and Willingness to Screen for Dementia Mon, 20 Apr 2015 07:07:01 +0000 http://www.hindawi.com/journals/jar/2015/423265/ Objective. To understand older primary care patients’ perceptions of the risks and benefits of dementia screening and to measure the association between attitudes and screening behaviors. Methods. Eligible patients completed the Perceptions Regarding Investigational Screening for Memory in Primary Care (PRISM-PC) questionnaire and then were asked to undergo dementia screening by a telephone screening instrument. Results. Higher scores on the PRISM-PC questionnaire items that measure attitudes about benefits of screening were associated with decreased odds of refusing screening. Participants who refused screening had significantly lower PRISM-PC questionnaire scores on the items that measure perceived benefits compared to those who agreed to screening. Participants who refused screening were less likely to agree on screening for other conditions, such as depression and cancer. Participants who know someone with Alzheimer’s disease (AD) were less likely to refuse screening. Discussion. Patients’ attitudes about the benefits of dementia screening are associated with their acceptance of dementia screening. Nicole R. Fowler, Anthony J. Perkins, Hilary A. Turchan, Amie Frame, Patrick Monahan, Sujuan Gao, and Malaz A. Boustani Copyright © 2015 Nicole R. Fowler et al. All rights reserved. 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling Thu, 19 Feb 2015 07:02:02 +0000 http://www.hindawi.com/journals/jar/2015/425261/ Royal jelly (RJ) produced by honeybees has been reported to possess diverse health-beneficial properties and has been implicated to have a function in longevity across diverse species as well as honeybees. 10-Hydroxy-2-decenoic acid (10-HDA), the major lipid component of RJ produced by honeybees, was previously shown to increase the lifespan of Caenorhabditis elegans. The objective of this study is to elucidate signaling pathways that are involved in the lifespan extension by 10-HDA. 10-HDA further extended the lifespan of the daf-2 mutants, which exhibit long lifespan through reducing insulin-like signaling (ILS), indicating that 10-HDA extended lifespan independently of ILS. On the other hand, 10-HDA did not extend the lifespan of the eat-2 mutants, which show long lifespan through dietary restriction caused by a food-intake defect. This finding indicates that 10-HDA extends lifespan through dietary restriction signaling. We further found that 10-HDA did not extend the lifespan of the long-lived mutants in daf-15, which encodes Raptor, a target of rapamycin (TOR) components, indicating that 10-HDA shared some longevity control mechanisms with TOR signaling. Additionally, 10-HDA was found to confer tolerance against thermal and oxidative stress. 10-HDA increases longevity not through ILS but through dietary restriction and TOR signaling in C. elegans. Yoko Honda, Yoko Araki, Taketoshi Hata, Kenji Ichihara, Masafumi Ito, Masashi Tanaka, and Shuji Honda Copyright © 2015 Yoko Honda et al. All rights reserved. The Relationship between Intramuscular Adipose Tissue, Functional Mobility, and Strength in Postmenopausal Women with and without Type 2 Diabetes Tue, 27 Jan 2015 09:25:18 +0000 http://www.hindawi.com/journals/jar/2015/872726/ Objectives. To determine (1) whether intramuscular adipose tissue (IntraMAT) differs between women with and without type 2 diabetes and (2) the association between IntraMAT and mobility and strength. Methods. 59 women ≥ 65 years with and without type 2 diabetes were included. A 1-Tesla MRI was used to acquire images of the leg. Timed-up-and-go (TUG) and grip strength were measured. Regression was used to determine associations between the following: (1) type 2 diabetes and IntraMAT (covariates: age, ethnicity, BMI, waist : hip ratio, and energy expenditure), (2) IntraMAT and TUG (covariates: diabetes, age, BMI, and energy expenditure), and (3) IntraMAT and grip strength (covariates: diabetes, age, height, and lean mass). Results. Women with diabetes had more IntraMAT. After adjustment, IntraMAT was similar between groups (diabetes mean [SD] = 13.2 [1.4]%, controls 11.8 [1.3]%, ). IntraMAT was related to TUG and grip strength, but the relationships became nonsignificant after adjustment for covariates (difference/percent IntraMAT [95% CI]: TUG = 0.041 seconds [−0.079–0.161], , grip strength = −0.144 kg [−0.335–0.066], ). Conclusions. IntraMAT alone may not be a clinically important predictor of functional mobility and strength; however, whether losses in functional mobility and strength are promoted by IntraMAT accumulation should be explored. Janet M. Pritchard, Sarah Karampatos, Karen A. Beattie, Lora M. Giangregorio, George Ioannidis, Stephanie A. Atkinson, Lehana Thabane, Hertzel Gerstein, Zubin Punthakee, Jonathan D. Adachi, and Alexandra Papaioannou Copyright © 2015 Janet M. Pritchard et al. All rights reserved. Efficacy of Female Rat Models in Translational Cardiovascular Aging Research Wed, 31 Dec 2014 09:24:03 +0000 http://www.hindawi.com/journals/jar/2014/153127/ Cardiovascular disease is the leading cause of death in women in the United States. Aging is a primary risk factor for the development of cardiovascular disease as well as cardiovascular-related morbidity and mortality. Aging is a universal process that all humans undergo; however, research in aging is limited by cost and time constraints. Therefore, most research in aging has been done in primates and rodents; however it is unknown how well the effects of aging in rat models translate into humans. To compound the complication of aging gender has also been indicated as a risk factor for various cardiovascular diseases. This review addresses the systemic pathophysiology of the cardiovascular system associated with aging and gender for aging research with regard to the applicability of rat derived data for translational application to human aging. K. M. Rice, J. C. Fannin, C. Gillette, and E. R. Blough Copyright © 2014 K. M. Rice et al. All rights reserved. The Combined Effects of Tai Chi, Resistance Training, and Diet on Physical Function and Body Composition in Obese Older Women Sun, 28 Dec 2014 09:16:50 +0000 http://www.hindawi.com/journals/jar/2014/657851/ Obesity is a major health problem in the USA, especially in minority populations over the age of 60 years, and the aging process can cause adverse effects on physical function. Previous research has shown that Tai Chi, resistance training (RT), and diet result in overall health improvements. However, the combination of these specific interventions has yet to be translated to obese older women in an urban setting. The purpose of this study was to examine a combined intervention on the primary outcomes of physical function and body composition. Using a nonrandomized design, 26 obese women ( years) completed a 12-week intervention; participants were assigned to an intervention (EXD) group or a control (CON) group. The EXD group () participated in Tai Chi, RT, and a dietary session. The CON group () was asked to continue their normal lifestyle. Timed up and go (TUG) time was reduced by seconds () in the EXD group while the CON group saw a borderline significant increase of 0.71 sec (). The combined intervention helped improve performance on TUG time, but there were no significant increases in other body composition or function measures. S. A. Maris, D. Quintanilla, A. Taetzsch, A. Picard, J. Letendre, L. Mahler, I. Lofgren, F. Xu, and M. J. Delmonico Copyright © 2014 S. A. Maris et al. All rights reserved. Sustainability Literacy of Older People in Retirement Villages Mon, 22 Dec 2014 10:13:32 +0000 http://www.hindawi.com/journals/jar/2014/919054/ With many developed countries experiencing the aging of the population, older people play a large role in contributing to environmental problems but also to environmental solutions. The purpose of this research is to understand the awareness and behavior of current older people living in retirement villages towards sustainability development. To achieve this, a sustainability literacy survey was conducted with 65 older residents of a private retirement village located 10 Km outside the Brisbane, Australia’s central business district (CBD). Most of residents recognized the importance of environment protection and would like to lead a more environmentally friendly lifestyle. In addition, the majority were willing to pay higher prices for a living environment with sustainable features. The importance of positive social communications was emphasized with most residents having established good relationships with others in the village. The findings provide an important insight into consumer perspectives regarding the sustainable features that should and can be incorporated into the village planning and development. Bo Xia, Jian Zuo, Martin Skitmore, Laurie Buys, and Xin Hu Copyright © 2014 Bo Xia et al. All rights reserved. Using Structured Observation and Content Analysis to Explore the Presence of Older People in Public Fora in Developing Countries Mon, 08 Dec 2014 00:10:11 +0000 http://www.hindawi.com/journals/jar/2014/860612/ There is a lack of research on the everyday lives of older people in developing countries. This exploratory study used structured observation and content analysis to examine the presence of older people in public fora and considered the methods’ potential for understanding older people’s social integration and inclusion. Structured observation occurred of public social spaces in six cities each located in a different developing country and in one city in the United Kingdom, together with content analysis of the presence of people in newspaper pictures and on television in the selected countries. Results indicated that across all fieldwork sites and data sources, there was a low presence of older people, with women considerably less present than men in developing countries. There was variation across fieldwork sites in older people’s presence by place and time of day and in their accompanied status. The presence of older people in images drawn from newspapers was associated with the news/non-news nature of the source. The utility of the study’s methodological approach is considered, as is the degree to which the presence of older people in public fora might relate to social integration and inclusion in different cultural contexts. Geraldine Nosowska, Kevin McKee, and Lena Dahlberg Copyright © 2014 Geraldine Nosowska et al. All rights reserved. Prevalence of Frailty Indicators and Association with Socioeconomic Status in Middle-Aged and Older Adults in a Swiss Region with Universal Health Insurance Coverage: A Population-Based Cross-Sectional Study Wed, 22 Oct 2014 11:18:03 +0000 http://www.hindawi.com/journals/jar/2014/198603/ Frailty prevalence in older adults has been reported but is largely unknown in middle-aged adults. We determined the prevalence of frailty indicators among middle-aged and older adults from a general Swiss population characterized by universal health insurance coverage and assessed the determinants of frailty with a special focus on socioeconomic status. Participants aged 50 and more from the population-based 2006–2010 Bus Santé study were included ( = 2,930). Four frailty indicators (weakness, shrinking, exhaustion, and low activity) were measured according to standard definitions. Multivariate logistic regressions were used to determine associations. Overall, 63.5%, 28.7%, and 7.8% participants presented no frailty indicators, one frailty indicator, and two or more frailty indicators, respectively. Among middle-aged participants (50–65 years), 75.1%, 22.2%, and 2.7% presented 0, 1, and 2 or more frailty indicators. The number of frailty indicators was positively associated with age, hypertension, and current smoking and negatively associated with male gender, body mass index, waist-to-hip ratio, and serum total cholesterol level. Lower income level but not education was associated with higher number of frailty indicators. Frailty indicators are frequently encountered in both older and middle-aged adults from the Swiss general population. Despite universal health insurance coverage, household income is independently associated with frailty. Idris Guessous, Jean-Christophe Luthi, Christopher Barrett Bowling, Jean-Marc Theler, Fred Paccaud, Jean-Michel Gaspoz, and William McClellan Copyright © 2014 Idris Guessous et al. All rights reserved. Geospatial Relationships between Awareness and Utilization of Community Exercise Resources and Physical Activity Levels in Older Adults Thu, 16 Oct 2014 07:28:44 +0000 http://www.hindawi.com/journals/jar/2014/302690/ Introduction. It is unclear if community-based fitness resources (CBFR) translate to heightened activity levels within neighboring areas. The purpose of this study was to determine whether awareness and utilization of fitness resources and physical activity differed depending on residential distance from CBFR. Methods. Four hundred and seventeen older adults ( years) were randomly recruited from three spatial tiers (≤1.6, >1.6 to ≤3.2, and >3.2 to 8.0 km) surrounding seven senior centers, which housed CBFR. Participants completed questionnaires on health history, CBFR, and physical activity, gathering data on CBFR awareness, utilization, and barriers, overall levels, and predictors to engagement in moderate to vigorous physical activity (MVPA). Results. Across spatial tiers, there were no differences in positive awareness rates of CBFR or CBFR utilization. Engagement in MVPA differed across spatial tiers , with the >3.2 to 8.0 km radius having the highest mean energy expenditure. Across all sites, age and income level were significant predictors of low and high amounts of MVPA, respectively, and current health status and lack of interest represented barriers to CBFR utilization . Conclusion. Closer proximity to CBFR did not impact awareness or utilization rates and had an inverse relationship with physical activity. Christopher J. Dondzila, Ann M. Swartz, Kevin G. Keenan, Amy E. Harley, Razia Azen, and Scott J. Strath Copyright © 2014 Christopher J. Dondzila et al. All rights reserved. Improving Quality of Life in Nursing Homes: The Structured Resident Interview Approach Thu, 09 Oct 2014 09:04:40 +0000 http://www.hindawi.com/journals/jar/2014/892679/ The quality of life (QOL) of the approximately 1.5 million nursing facility (NF) residents in the US is undoubtedly lower than desired by residents, families, providers, and policy makers. Although there have been important advances in defining and measuring QOL for this population, there is a need for interventions that are tied to standardized measurement and quality improvement programs. This paper describes the development and testing of a structured, tailored assessment and care planning process for improving the QOL of nursing home residents. The Quality of Life Structured Resident Interview and Care Plan (QOL.SRI/CP) builds on a decade of research on measuring QOL and is designed to be easily implemented in any US nursing home. The approach was developed through extensive and iterative pilot testing and then tested in a randomized controlled trial in three nursing homes. Residents were randomly assigned to receive the assessment alone or both the assessment and an individualized QOL care plan task. The results show that residents assigned to the intervention group experienced improved QOL at 90- and 180-day follow-up, while QOL of residents in the control group was unchanged. Howard B. Degenholtz, Abby L. Resnick, Natalie Bulger, and Lichun Chia Copyright © 2014 Howard B. Degenholtz et al. All rights reserved. Is the Cloze Procedure Appropriate to Evaluate Health Literacy in Older Individuals? Age Effects in the Test of Functional Health Literacy in Adults Thu, 11 Sep 2014 06:27:39 +0000 http://www.hindawi.com/journals/jar/2014/194635/ Health literacy has received increasing attention because of its importance for older individuals’ health, as studies have shown a close relation between older individuals’ health literacy and their health. Research also suggests that older individuals have low levels of health literacy, but this finding is variable and may depend on which health literacy test is used. Older individuals assessed with the Test of Functional Health Literacy (TOFHLA) score lower than younger individuals, but a previous study suggested that this may result from age-related differential item functioning (DIF) on the TOFHLA. The study reported here assessed age-related DIF in a sample of community-dwelling volunteers. Twenty-two percent of items were differentially more difficult for older individuals independent of their overall ability, and when these items were eliminated from the total score, age differences were no longer found. Performance on a working memory task predicted older but not younger individuals’ performance on the age-related items. At least part of older individuals’ apparent deficits in health literacy when assessed by the TOFHLA may be related to DIF on its items. The TOFHLA, and any measure that employs the cloze procedure to evaluate reading comprehension, should be used cautiously in older individuals. Raymond L. Ownby, Amarilis Acevedo, Drenna Waldrop-Valverde, and Robin J. Jacobs Copyright © 2014 Raymond L. Ownby et al. All rights reserved. Could Some Geriatric Characteristics Hinder the Prescription of Anticoagulants in Atrial Fibrillation in the Elderly? Wed, 10 Sep 2014 00:00:00 +0000 http://www.hindawi.com/journals/jar/2014/693740/ Several studies have reported underprescription of anticoagulants in atrial fibrillation (AF). We conducted an observational study on 142 out of a total of 995 consecutive ≥75 years old patients presenting AF (14%) when admitted in an emergency unit of a general hospital, in search of geriatric characteristics that might be associated with the underprescription of anticoagulation therapy (mostly antivitamin K at the time of the study). The following data was collected from patients presenting AF: medical history including treatment and comorbidities, CHADS2 score, ISAR scale (frailty), Lawton’s scale (ADL), GDS scale (mood status), MUST (nutrition), and blood analysis (INR, kidney function, and albumin). Among those patients for who anticoagulation treatment was recommended (73%), only 61% were treated with it. In the group with anticoagulation therapy, the following characteristics were observed more often than in the group without such therapy: a recent (≤6 months) hospitalization and medical treatment including digoxin or based on >3 different drugs. Neither the value of the CHADS2 score, nor the geriatric characteristics could be correlated with the presence or the absence of an anticoagulation therapy. More research is thus required to identify and clarify the relative importance of patient-, physician-, and health care system-related hurdles for the prescription of oral anticoagulation therapy in older patients with AF. Paule Denoël, Jacques Vanderstraeten, Pierre Mols, and Thierry Pepersack Copyright © 2014 Paule Denoël et al. All rights reserved. Employing a Participatory Research Approach to Explore Physical Activity among Older African American Women Thu, 21 Aug 2014 00:00:00 +0000 http://www.hindawi.com/journals/jar/2014/941019/ Introduction. Older African American women are particularly vulnerable to unhealthy lifestyle behaviors such as physical inactivity and the resultant chronic diseases and conditions. This study explored older African American women’s perception of physical activity as well as facilitators of and barriers to being physically active in their local environment. Methods. Using a participatory research approach, a total of 7 women aged 65 years and over had their PA level assessed objectively through accelerometry. In addition, physical activity was discussed through the photo-elicitation procedure, which was supplemented by semistructured interviews. Qualitative thematic analysis was used to identify patterns and themes emerging from participants’ interview. Results. Participants exhibited low levels of physical activity and viewed “physical activity” to be a broadly defined, nonspecific construct. Interviews revealed that many participants lack important knowledge about physical activity. A variety of personal, social, and environmental facilitators and barriers were reported by the participants. Conclusion. Efforts should be made towards clarifying information on physical activity in this population in order to help them incorporate physical activity into their routines, overcome barriers, and make use of opportunities to be active. Emerson Sebastião, Kelechi Ibe-Lamberts, Julie Bobitt, Andiara Schwingel, and Wojtek Chodzko-Zajko Copyright © 2014 Emerson Sebastião et al. All rights reserved.