Journal of Biomedicine and Biotechnology
Volume 2006 (2006), Article ID 69141, 11 pages
doi:10.1155/JBB/2006/69141
Research Article

Towards a Holistic, Yet Gene-Centered Analysis of Gene Expression Profiles: A Case Study of Human Lung Cancers

Yuchun Guo,1 Gabriel S. Eichler,2,3 Ying Feng,1 Donald E. Ingber,1 and Sui Huang1

1Vascular Biology Program, Department of Surgery, Children's Hospital, Harvard Medical School, Boston 02115, MA, USA
2Bioinformatics Program, Boston University, Boston 02215, MA, USA
3Laboratory of Molecular Pharmacology, CCR, NCI, NIH, Bethesda 20892, MD, USA

Received 2 June 2006; Revised 14 August 2006; Accepted 25 August 2006

Copyright © 2006 Yuchun Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Additional relevant information and results

This PDF file provides additional relevant information and results: the parameters in the GEDI software, the results of GEDI maps produced with different parameters, results showing the differences between Sq2 and other Sq samples in more details, and the description of the method of GO-based EASE functional enrichment analysis.

Detailed gene information

This is a Microsoft Excel spreadsheet containing the detailed gene information of the 4 “gene islands” in the SmC-Lung difference map and the result of EASE analysis of functional enrichment for these 4 islands. The first 4 sheets contain the gene information, such as Affymetrix ID, GEDI Map coordinates, gene symbols, and gene ontology terms for genes on each of the 4 islands. The last 4 sheets contain the results of GO based EASE functional enrichment analysis of the 4 islands.

  1. Additional relevant information and results
  2. Detailed gene information