]>Metabolic Control Analysis: A Tool for Designing Strategies to Manipulate Metabolic Pathways : Table 4
Table 4: Control of GSH and PC synthesis in plants exposed to C d 2 + .
Enzyme1x γ-ECS + PCS2.5x γ-ECS + PCS
𝐶 𝐽 G S H 𝑣 𝑖 𝐶 𝐽 P C 𝑣 𝑖 𝐶 G S H 𝑣 𝑖 𝐶 P C 𝑣 𝑖 𝐶 𝐽 G S H 𝑣 𝑖 𝐶 𝐽 P C 𝑣 𝑖 𝐶 G S H 𝑣 𝑖 𝐶 P C 𝑣 𝑖
γ-ECS0.580.600.680.760.450.610.700.60
GS<0.01<0.010.010.010.19<0.01<0.010.97
GS-transferase0.01−0.06−0.07−0.07<0.01<0.01 < − 0 . 0 1 −0.05
PCS0.400.44−0.63−0.560.330.44−0.620.57
vacuole PC-Cd transporter<0.01<0.01<0.01−1.2<0.01 <0.01 <0.01−2.1
𝐶 𝐽 G S H 𝑣 𝑖 , control coefficient of enzyme 𝑖 in GSH synthesis; 𝐶 𝐽 P C 𝑣 𝑖 , control coefficient of enzyme Ei on PCs synthesis; 𝐶 G S H 𝑣 𝑖 , control coefficient of enzyme 𝑖 on GSH concentration; 𝐶 P C 𝑣 𝑖 , control coefficient of enzyme 𝑖 on PCs concentration. An enzyme with a negative flux control indicates that it is localized in a branch, turning aside the principal flux; an enzyme with a negative concentration control indicates that an increase in its activity decreases metabolite concentration.