Journal of Biomedicine and Biotechnology
Volume 2009 (2009), Article ID 451084, 10 pages
doi:10.1155/2009/451084
Research Article
Mesothelioma Cells Escape Heat Stress by Upregulating Hsp40/Hsp70 Expression via Mitogen-Activated Protein Kinases
1Molecular Medicine Research Group, The Woolcock Institute for Medical Research, University of Sydney, 20 Missendon Road, Camperdown, NSW 2050, Australia
2Pulmonary Cell Research, Department of Internal Medicine and Research, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland
3Respiratory Cell Research & Pneumology, Lab 305, University Hospital Basel, Hebelstrasse 20, CH-4031 Basel, Switzerland
Received 23 February 2009; Accepted 6 April 2009
Academic Editor: Paul Higgins
Copyright © 2009 Michael Roth et al. This is an open access article distributed under the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- B. W. S. Robinson and R. A. Lake, “Advances in malignant mesothelioma,” The New England Journal of Medicine, vol. 353, no. 15, pp. 1591–1603, 2005. View at Publisher · View at Google Scholar · View at PubMed
- E. de Bree, S. van Ruth, P. Baas, et al., “Cytoreductive surgery and intraoperative hyperthermic intrathoracic chemotherapy in patients with malignant pleural mesothelioma or pleural metastases of thymoma,” Chest, vol. 121, no. 2, pp. 480–487, 2002. View at Publisher · View at Google Scholar
- W. G. Richards, L. Zellos, R. Bueno, et al., “Phase I to II study of pleurectomy/decortication and intraoperative intracavitary hyperthermic cisplatin lavage for mesothelioma,” Journal of Clinical Oncology, vol. 24, no. 10, pp. 1561–1567, 2006. View at Publisher · View at Google Scholar · View at PubMed
- P. H. Sugarbaker, “Laboratory and clinical basis for hyperthermia as a component of intracavitary chemotherapy,” International Journal of Hyperthermia, vol. 23, no. 5, pp. 431–442, 2007. View at Publisher · View at Google Scholar · View at PubMed
- V. L. Roggli, A. Sharma, K. J. Butnor, T. Sporn, and R. T. Vollmer, “Malignant mesothelioma and occupational exposure to asbestos: a clinicopathological correlation of 1445 cases,” Ultrastructural Pathology, vol. 26, no. 2, pp. 55–65, 2002. View at Publisher · View at Google Scholar · View at PubMed
- P. Bertino, A. Marconi, L. Palumbo, et al., “Erionite and asbestos differently cause transformation of human mesothelial cells,” International Journal of Cancer, vol. 121, no. 1, pp. 12–20, 2007. View at Publisher · View at Google Scholar · View at PubMed
- K. Pelin, A. Hirvonen, and K. Linnainmaa, “Expression of cell adhesion molecules and connexins in gap junctional intercellular communication deficient human mesothelioma tumour cell lines and communication competent primary mesothelial cells,” Carcinogenesis, vol. 15, no. 11, pp. 2673–2675, 1994. View at Publisher · View at Google Scholar
- D. W. Kamp, V. A. Israbian, S. E. Preusen, C. X. Zhang, and S. A. Weitzman, “Asbestos causes DNA strand breaks in cultured pulmonary epithelial cells: role of iron-catalyzed free radicals,” American Journal of Physiology, vol. 268, no. 3, pp. L471–L480, 1995.
- J. T. Hodgson and A. Darnton, “The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure,” Annals of Occupational Hygiene, vol. 44, no. 8, pp. 565–601, 2000. View at Publisher · View at Google Scholar
- K.-Y. Hung, C.-T. Chen, C.-J. Yen, P.-H. Lee, T.-J. Tsai, and B.-S. Hsieh, “Dipyridamole inhibits PDGF-stimulated human peritoneal mesothelial cell proliferation,” Kidney International, vol. 60, no. 3, pp. 872–881, 2001. View at Publisher · View at Google Scholar · View at PubMed
- C. A. Barlow, T. F. Barrett, A. Shukla, B. T. Mossman, and K. M. Lounsbury, “Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal-regulated kinases 1/2,” American Journal of Physiology, vol. 292, no. 6, pp. L1361–L1369, 2007. View at Publisher · View at Google Scholar · View at PubMed
- C. L. Zanella, J. Posada, T. R. Tritton, and B. T. Mossman, “Asbestos causes stimulation of the extracellular signal-regulated kinase 1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor,” Cancer Research, vol. 56, no. 23, pp. 5334–5338, 1996.
- L. Vintman, S. Nielsen, A. Berner, R. Reich, and B. Davidson, “Mitogen-activated protein kinase expression and activation does not differentiate benign from malignant mesothelial cells,” Cancer, vol. 103, no. 11, pp. 2427–2433, 2005. View at Publisher · View at Google Scholar · View at PubMed
- W. A. Swain, K. J. O'Byrne, and S. P. Faux, “Activation of p38 MAP kinase by asbestos in rat mesothelial cells is mediated by oxidative stress,” American Journal of Physiology, vol. 286, no. 4, pp. L859–L865, 2004.
- S. Wakchoure, M. A. Merrell, W. Aldrich, et al., “Bisphosphonates inhibit the growth of mesothelioma cells in vitro and in vivo,” Clinical Cancer Research, vol. 12, no. 9, pp. 2862–2868, 2006. View at Publisher · View at Google Scholar · View at PubMed
- J. Zhong, M. M. Gencay, L. Bubendorf, et al., “ERK1/2 and p38 MAP kinase control MMP-2, MT1-MMP, and TIMP action and affect cell migration: a comparison between mesothelioma and mesothelial cells,” Journal of Cellular Physiology, vol. 207, no. 2, pp. 540–552, 2006. View at Publisher · View at Google Scholar · View at PubMed
- S. Inoue, H. Motoda, Y. Koike, K. Kawamura, F. Hiragami, and Y. Kano, “Microwave irradiation induces neurite outgrowth in PC12m3 cells via the p38 mitogen-activated protein kinase pathway,” Neuroscience Letters, vol. 432, no. 1, pp. 35–39, 2008. View at Publisher · View at Google Scholar · View at PubMed
- E. R. Nielsen, Y. E. G. Eskildsen-Helmond, and S. I. S. Rattan, “MAP kinases and heat shock-induced hormesis in human fibroblasts during serial passaging in vitro,” Annals of the New York Academy of Sciences, vol. 1067, pp. 343–348, 2006. View at Publisher · View at Google Scholar · View at PubMed
- C. D. Venkatakrishnan, A. K. Tewari, L. Moldovan, et al., “Heat shock protects cardiac cells from doxorubicin-induced toxicity by activating p38 MAPK and phosphorylation of small heat shock protein 27,” American Journal of Physiology, vol. 291, no. 6, pp. H2680–H2691, 2006. View at Publisher · View at Google Scholar · View at PubMed
- N. Narita, I. Noda, T. Ohtsubo, et al., “Analysis of heat-shock related gene expression in head-and-neck cancer using cDNA arrays,” International Journal of Radiation Oncology, Biology, Physics, vol. 53, no. 1, pp. 190–196, 2002. View at Publisher · View at Google Scholar
- A. R. Taylor, M. B. Robinson, D. J. Gifondorwa, M. Tytell, and C. E. Milligan, “Regulation of heat shock protein 70 release in astrocytes: role of signaling kinases,” Developmental Neurobiology, vol. 67, no. 13, pp. 1815–1829, 2007. View at Publisher · View at Google Scholar · View at PubMed
- P. Rafiee, M. E. Theriot, V. M. Nelson, et al., “Human esophageal microvascular endothelial cells respond to acidic pH stress by PI3K/AKT and p38 MAPK-regulated induction of Hsp70 and Hsp27,” American Journal of Physiology, vol. 291, no. 5, pp. C931–C945, 2006. View at Publisher · View at Google Scholar · View at PubMed
- L. Schiaffonati, P. Maroni, P. Bendinelli, L. Tiberio, and R. Piccoletti, “Hyperthermia induces gene expression of heat shock protein 70 and phosphorylation of mitogen activated protein kinases in the rat cerebellum,” Neuroscience Letters, vol. 312, no. 2, pp. 75–78, 2001. View at Publisher · View at Google Scholar
- W. Hu, W. Wu, S.-C. Yeung, R. S. Freedman, J. J. Kavanagh, and C. F. Verschraegen, “Increased expression of heat shock protein 70 in adherent ovarian cancer and mesothelioma following treatment with manumycin, a farnesyl transferase inhibitor,” Anticancer Research, vol. 22, no. 2A, pp. 665–672, 2002.
- S. K. Calderwood and D. R. Ciocca, “Heat shock proteins: stress proteins with Janus-like properties in cancer,” International Journal of Hyperthermia, vol. 24, no. 1, pp. 31–39, 2008. View at Publisher · View at Google Scholar · View at PubMed
- A. Ito, H. Honda, and T. Kobayashi, “Cancer immunotherapy based on intracellular hyperthermia using magnetite nanoparticles: a novel concept of “heat-controlled necrosis” with heat shock protein expression,” Cancer Immunology, Immunotherapy, vol. 55, no. 3, pp. 320–328, 2006. View at Publisher · View at Google Scholar · View at PubMed
- R. A. Coss, “Inhibiting induction of heat shock proteins as a strategy to enhance cancer therapy,” International Journal of Hyperthermia, vol. 21, no. 8, pp. 695–701, 2005. View at Publisher · View at Google Scholar · View at PubMed
- V. Milani and E. Noessner, “Effects of thermal stress on tumor antigenicity and recognition by immune effector cells,” Cancer Immunology, Immunotherapy, vol. 55, no. 3, pp. 312–319, 2006. View at Publisher · View at Google Scholar · View at PubMed
- H. P. Kim, X. Wang, J. Zhang, et al., “Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 MAPK and heat shock factor-1,” The Journal of Immunology, vol. 175, no. 4, pp. 2622–2629, 2005.
- O. Eickelberg, M. Roth, R. Lörx, et al., “Ligand-independent activation of the glucocorticoid receptor by -adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells,” The Journal of Biological Chemistry, vol. 274, no. 2, pp. 1005–1010, 1999. View at Publisher · View at Google Scholar
- Y. Soini, K. Kahlos, R. Sormunen, et al., “Activation and relocalization of caspase 3 during the apoptotic cascade of human mesothelioma cells,” APMIS, vol. 113, no. 6, pp. 426–435, 2005. View at Publisher · View at Google Scholar
- C. Jolly and R. I. Morimoto, “Role of the heat shock response and molecular chaperones in oncogenesis and cell death,” Journal of the National Cancer Institute, vol. 92, no. 19, pp. 1564–1572, 2000. View at Publisher · View at Google Scholar
- C.-Y. Fan, S. Lee, and D. M. Cyr, “Mechanisms for regulation of Hsp70 function by Hsp40,” Cell Stress and Chaperones, vol. 8, no. 4, pp. 309–316, 2003.
- S.-A. Kim, S. Chang, J.-H. Yoon, and S.-G. Ahn, “TAT-Hsp40 inhibits oxidative stress-mediated cytotoxicity via the inhibition of Hsp70 ubiquitination,” FEBS Letters, vol. 582, no. 5, pp. 734–740, 2008. View at Publisher · View at Google Scholar · View at PubMed
- R. Kaneko, Y. Hayashi, I. Tohnai, M. Ueda, and K. Ohtsuka, “Hsp40, a possible indicator for thermotolerance of murine tumour in vivo,” International Journal of Hyperthermia, vol. 13, no. 5, pp. 507–516, 1997. View at Publisher · View at Google Scholar
- Y. Uchiyama, N. Takeda, M. Mori, and K. Terada, “Heat shock protein 40/DjB1 is required for thermotolerance in early phase,” Journal of Biochemistry, vol. 140, no. 6, pp. 805–812, 2006. View at Publisher · View at Google Scholar · View at PubMed
- R. E. Marks, A. W. Ho, C. Robbel, T. Kuna, S. Berk, and T. F. Gajewski, “Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level,” Blood, vol. 110, no. 6, pp. 1982–1988, 2007. View at Publisher · View at Google Scholar · View at PubMed
- R. Kurzrock, H. M. Kantarjian, J. E. Cortes, et al., “Farnesyltransferase inhibitor R115777 in myelodysplastic syndrome: clinical and biologic activities in the phase 1 setting,” Blood, vol. 102, no. 13, pp. 4527–4534, 2003. View at Publisher · View at Google Scholar · View at PubMed
- M. Garmyn, T. Mammone, A. Pupe, D. Gan, L. Declercq, and D. Maes, “Human keratinocytes respond to osmotic stress by p38 map kinase regulated induction of HSP70 and HSP27,” The Journal of Investigative Dermatology, vol. 117, no. 5, pp. 1290–1295, 2001. View at Publisher · View at Google Scholar · View at PubMed