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Figure 1: APP  or  BACE1  upregulation  might  lead  to    overproduction  in  Alzheimer’s  Disease. The picture shows molecular pathways modulating APP and BACE1 expression and amyloidogenic processing of APP by BACE1 and the -secretase complex leading to production. Reduction of miRNA/RISC posttranscriptional regulation of APP and/or BACE1 mRNA induces the increase of the relative proteins, which drive to accumulation. Changes of miRNA expression might trigger molecular events inducing AD pathology or generate a feed-forward mechanism during AD progression (as suggested for miR-298 and miR-328).