Journal of Biomedicine and Biotechnology
Volume 2009 (2009), Article ID 871313, 8 pages
doi:10.1155/2009/871313
Review Article
Searching for MIND: MicroRNAs in Neurodegenerative Diseases
1European Brain Research Institute (EBRI), Fondazione EBRI- Rita Levi-Montalcini, Via del Fosso di Fiorano 64/65, 00143 Roma, Italy
2Istituto di Neurobiologia e Medicina Molecolare (INMM), CNR, Via del Fosso di Fiorano 64/65, 00143 Roma, Italy
3Dipartimento di Biotecnologie Cellulari ed Ematologia, Sezione di Genetica Molecolare, Università di Roma “La Sapienza”, Viale Regina Elena 324, 00161 Roma, Italy
Received 9 January 2009; Accepted 12 June 2009
Academic Editor: Pawan Malhotra
Copyright © 2009 Christian Barbato et al. This is an open access article distributed under the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- D. M. Skovronsky, V. M.-Y. Lee, and J. Q. Trojanowski, “Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications,” Annual Review of Pathology, vol. 1, pp. 151–170, 2006. View at Publisher · View at Google Scholar · View at PubMed
- D. P. Bartel, “MicroRNAs: genomics, biogenesis, mechanism, and function,” Cell, vol. 116, no. 2, pp. 281–297, 2004. View at Publisher · View at Google Scholar
- K. S. Kosik, “The neuronal microRNA system,” Nature Reviews Neuroscience, vol. 7, no. 12, pp. 911–920, 2006. View at Publisher · View at Google Scholar · View at PubMed
- C. Barbato, C. Giorgi, C. Catalanotto, and C. Cogoni, “Thinking about RNA? MicroRNAs in the brain,” Mammalian Genome, vol. 19, no. 7-8, pp. 541–551, 2008. View at Publisher · View at Google Scholar · View at PubMed
- M. Selbach, B. Schwanhäusser, N. Thierfelder, Z. Fang, R. Khanin, and N. Rajewsky, “Widespread changes in protein synthesis induced by microRNAs,” Nature, vol. 455, no. 7209, pp. 58–63, 2008. View at Publisher · View at Google Scholar · View at PubMed
- D. Baek, J. Villén, C. Shin, F. D. Camargo, S. P. Gygi, and D. P. Bartel, “The impact of microRNAs on protein output,” Nature, vol. 455, no. 7209, pp. 64–71, 2008. View at Publisher · View at Google Scholar · View at PubMed
- E. Berezikov, F. Thuemmler, L. W. van Laake, et al., “Diversity of microRNAs in human and chimpanzee brain,” Nature Genetics, vol. 38, no. 12, pp. 1375–1377, 2006. View at Publisher · View at Google Scholar · View at PubMed
- C. Haass and D. J. Selkoe, “Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid -peptide,” Nature Reviews Molecular Cell Biology, vol. 8, no. 2, pp. 101–112, 2007. View at Publisher · View at Google Scholar · View at PubMed
- H. Braak and E. Braak, “Neuropathological staging of Alzheimer-related changes,” Acta Neuropathologica, no. 82, pp. 239–259, 1991. View at Publisher · View at Google Scholar
- W. J. Lukiw, “Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus,” NeuroReport, vol. 18, no. 3, pp. 297–300, 2007. View at Publisher · View at Google Scholar · View at PubMed
- S. S. Hébert, K. Horré, L. Nicolaï, et al., “Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/-secretase expression,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 17, pp. 6415–6420, 2008. View at Publisher · View at Google Scholar · View at PubMed
- J. P. Cogswell, J. Ward, I. A. Taylor, et al., “Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways,” Journal of Alzheimer's Disease, vol. 14, no. 1, pp. 27–41, 2008.
- P. Formichi, C. Battisti, E. Radi, and A. Federico, “Cerebrospinal fluid tau, A, and phosphorylated tau protein for the diagnosis of Alzheimer's disease,” Journal of Cellular Physiology, vol. 208, no. 1, pp. 39–46, 2006. View at Publisher · View at Google Scholar · View at PubMed
- W.-X. Wang, B. W. Rajeev, A. J. Stromberg, et al., “The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of -site amyloid precursor protein-cleaving enzyme 1,” Journal of Neuroscience, vol. 28, no. 5, pp. 1213–1223, 2008. View at Publisher · View at Google Scholar · View at PubMed
- V. Boissonneault, I. Plante, S. Rivest, and P. Provost, “MicroRNA-298 and microRNA-328 regulate expression of mouse -amyloid precursor protein-converting enzyme 1,” Journal of Biological Chemistry, vol. 284, no. 4, pp. 1971–1981, 2009. View at Publisher · View at Google Scholar · View at PubMed
- R. Niwa, F. Zhou, C. Li, and F. J. Slack, “The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans,” Developmental Biology, vol. 315, no. 2, pp. 418–425, 2008. View at Publisher · View at Google Scholar · View at PubMed
- N. Patel, D. Hoang, N. Miller, et al., “MicroRNAs can regulate human APP levels,” Molecular Neurodegeneration, vol. 3, no. 1, p. 10, 2008. View at Publisher · View at Google Scholar · View at PubMed
- W. Mandemakers, V. A. Morais, and B. De Strooper, “A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases,” Journal of Cell Science, vol. 120, no. 10, pp. 1707–1716, 2007. View at Publisher · View at Google Scholar · View at PubMed
- J. Kim, K. Inoue, J. Ishii, et al., “A microRNA feedback circuit in midbrain dopamine neurons,” Science, vol. 317, no. 5842, pp. 1220–1224, 2007. View at Publisher · View at Google Scholar · View at PubMed
- G. Wang, J. M. van der Walt, G. Mayhew, et al., “Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of -Synuclein,” American Journal of Human Genetics, vol. 82, no. 2, pp. 283–289, 2008. View at Publisher · View at Google Scholar · View at PubMed
- P. Siwach and S. Ganesh, “Tandem repeats in human disorders: mechanisms and evolution,” Frontiers in Bioscience, vol. 13, no. 12, pp. 4467–4484, 2008. View at Publisher · View at Google Scholar
- J. M. Gil and A. C. Rego, “Mechanisms of neurodegeneration in Huntington's disease,” European Journal of Neuroscience, vol. 27, no. 11, pp. 2803–2820, 2008. View at Publisher · View at Google Scholar · View at PubMed
- C. Conaco, S. Otto, J.-J. Han, and G. Mandel, “Reciprocal actions of REST and a microRNA promote neuronal identity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 7, pp. 2422–2427, 2006. View at Publisher · View at Google Scholar · View at PubMed
- R. Johnson, C. Zuccato, N. D. Belyaev, D. J. Guest, E. Cattaneo, and N. J. Buckley, “A microRNA-based gene dysregulation pathway in Huntington's disease,” Neurobiology of Disease, vol. 29, no. 3, pp. 438–445, 2008. View at Publisher · View at Google Scholar · View at PubMed
- J. N. Savas, A. Makusky, S. Ottosen, et al., “Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 31, pp. 10820–10825, 2008. View at Publisher · View at Google Scholar · View at PubMed
- F. Jiang, X. Ye, X. Liu, L. Fincher, D. McKearin, and Q. Liu, “Dicer-1 and R3D1-L catalyze microRNA maturation in Drosophila,” Genes and Development, vol. 19, no. 14, pp. 1674–1679, 2005. View at Publisher · View at Google Scholar · View at PubMed
- J. Bilen, N. Liu, B. G. Burnett, R. N. Pittman, and N. M. Bonini, “MicroRNA pathways modulate polyglutamine-induced neurodegeneration,” Molecular Cell, vol. 24, no. 1, pp. 157–163, 2006. View at Publisher · View at Google Scholar · View at PubMed
- A. Schaefer, D. O'Carroll, C. L. Tan, et al., “Cerebellar neurodegeneration in the absence of microRNAs,” Journal of Experimental Medicine, vol. 204, no. 7, pp. 1553–1558, 2007. View at Publisher · View at Google Scholar · View at PubMed
- Y. Lee, R. C. Samaco, J. R. Gatchel, C. Thaller, H. T. Orr, and H. Y. Zoghbi, “miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis,” Nature Neuroscience, vol. 11, no. 10, pp. 1137–1139, 2008. View at Publisher · View at Google Scholar · View at PubMed
- N. J. Cairns, E. H. Bigio, I. R. A. Mackenzie, et al., “Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration,” Acta Neuropathologica, vol. 114, no. 1, pp. 5–22, 2007. View at Publisher · View at Google Scholar · View at PubMed
- R. Saba, C. D. Goodman, R. L. C. H. Huzarewich, C. Robertson, and S. A. Booth, “A miRNA signature of prion induced neurodegeneration,” PLoS ONE, vol. 3, no. 11, p. e3652, 2008. View at Publisher · View at Google Scholar · View at PubMed
- R. Rademakers, J. L. Eriksen, M. Baker, et al., “Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia,” Human Molecular Genetics, vol. 17, no. 23, pp. 3631–3642, 2008. View at Publisher · View at Google Scholar · View at PubMed
- A. Aguzzi, F. Baumann, and J. Bremer, “The prion's elusive reason for being,” Annual Review of Neuroscience, vol. 31, pp. 439–477, 2008. View at Publisher · View at Google Scholar · View at PubMed
- G. Sorensen, S. Medina, D. Parchaliuk, C. Phillipson, C. Robertson, and S. A. Booth, “Comprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genes,” BMC Genomics, vol. 9, article 114, 2008. View at Publisher · View at Google Scholar · View at PubMed
- G. Meister, M. Landthaler, Y. Dorsett, and T. Tuschl, “Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing,” RNA, vol. 10, no. 3, pp. 544–550, 2004. View at Publisher · View at Google Scholar
- M. S. Ebert, J. R. Neilson, and P. A. Sharp, “MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells,” Nature Methods, vol. 4, no. 9, pp. 721–726, 2007. View at Publisher · View at Google Scholar · View at PubMed