]>Cytotoxic Effect of Recombinant <i>Mycobacterium tuberculosis</i> CFP-10/ESAT-6 Protein on the Crucial Pathways of WI-38 Cells : Table 2
Table 2: Gene names, gene descriptions, and significance analysis results of mapped genes in focal adhesion pathway obtained via SAM analysis, where “ [ ] ’’ showed upregulated ( + ) or downregulated ( ) by rCFES treatment at q-value < 5%.

No.GeneGene Description 𝑞 -value

1SHC3SHC transforming protein 30.0000 [ + ]
2ACTN2Actinin, alpha 20.0068 [ + ]
3BIRC3Baculoviral IAP repeat-containing 30.0211 [ + ]
4SPP1Secreted phosphoprotein 10.0211 [ + ]
5AF086032Protein phosphatase 1, regulatory (inhibitor) subunit 12A0.0278 [ + ]
6KDRKinase insert domain receptor 0.0278 [ + ]
7DDI1DDI1, DNA-damage inducible 1,homolog 1 (S. cerevisiae)0.0278 [ + ]
8ACTBActin, beta0.0000 [ ]
9FLNAFilamin A, alpha(actin binding protein 280)0.0000 [ ]
10ACTG1Actin, gamma 10.0000 [ ]
11CAV1Caveolin 1, caveolae protein, 22kDa0.0000 [ ]
12ITGB1Integrin, beta 10.0000 [ ]
13ITGA6Integrin, alpha 60.0000 [ ]
14COL1A2Collagen, type I, alpha 20.0000 [ ]
15CAPN2Calpain 2, (m/II) large subunit0.0000 [ ]
16AKT1V-akt murine thymoma viral oncogene homolog 10.0010 [ ]
17TNXBTenascin XB0.0010 [ ]
18ITGA5Integrin, alpha 5(fibronectin receptor, alpha polypeptide)0.0010 [ ]
19RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.0014 [ ]
20ITGA8Integrin, alpha 80.0014 [ ]
21ITGA4Integrin, alpha 40.0014 [ ]
22PIK3R3Phosphoinositide-3-kinase,regulatory subunit 3 (p55, gamma)0.0014 [ ]
23FN1Fibronectin 10.0014 [ ]
24LAMA4Laminin, alpha 40.0016 [ ]
25THBS1Thrombospondin 10.0016 [ ]
26IGF1RInsulin-like growth factor 1 receptor0.0016 [ ]
27COL1A1Collagen, type I, alpha 10.0016 [ ]
28CCND1Cyclin D10.0016 [ ]
29METMet proto-oncogene(hepatocyte growth factor receptor)0.0016 [ ]
30ACTN4Actinin, alpha 40.0019 [ ]
31AK025363Parvin, alpha0.0019 [ ]
32AKT2V-akt murine thymoma viral oncogene homolog 20.0019 [ ]
33CAV2Caveolin 20.0027 [ ]
34VCLVinculin0.0027 [ ]
35ZYXZyxin0.0027 [ ]
36TNCTenascin C (hexabrachion)0.0027 [ ]
37ACTN3Actinin, alpha 30.0028 [ ]
38VASPVasodilator-stimulated phosphoprotein0.0028 [ ]
39COL5A1Collagen, type V, alpha 10.0028 [ ]
40VEGFCVascular endothelial growth factor C0.0039 [ ]
41FAKFocal adhesion kinase0.0047 [ ]
42PARVBParvin, beta0.0047 [ ]
43COL4A6Collagen, type IV, alpha 60.0047 [ ]
44LAMA5Laminin, alpha 50.0068 [ ]
45MAPK1Mitogen-activated protein kinase 10.0088 [ ]
46AK025363Parvin, alpha0.0019 [ ]
47THBS4Thrombospondin 40.0116 [ ]
48ERBB2V-erb-b2 erythroblastic leukemiaviral oncogene homolog 20.0157 [ ]
49AF207599Homo sapiens pRb-interacting protein RbBP-36 mRNA0.0157 [ ]
50DOCK1Dedicator of cytokinesis 10.0157 [ ]
51COL5A2Collagen, type V, alpha 20.0211 [ ]
52PIK3R5Phosphoinositide-3-kinase, regulatory subunit 5, p1010.0211 [ ]
53ITGAVIntegrin, alpha V 0.0211 [ ]
54LAMA2Laminin, alpha 2 0.0278 [ ]
55ARHGAP5Rho GTPase activating protein 50.0278 [ ]
56VAV2Vav 2 oncogene0.0278 [ ]
57CAV3Caveolin 30.0278 [ ]
58BCAR1Breast cancer anti-estrogen resistance 10.0369 [ ]
59EGFREpidermal growth factor receptor0.0369 [ ]
60MAPK9Mitogen-activated protein kinase 90.0369 [ ]
61AA599881Platelet-derived growth factor receptor, alpha polypeptide0.0474 [ ]
62THBS1Thrombospondin 10.0016 [ ]
63GRB2Growth factor receptor-bound protein 20.0474 [ ]
64LAMA3Laminin, alpha 30.0474 [ ]
65CRKLV-crk sarcoma virus CT10 oncogene homolog (avian)-like0.0474 [ ]