Table 5: Distribution of CDKN2A rs36228834 and CDKN2B rs36229158 genotypes and associated risk estimates for pre-B ALL susceptibility among children.
Gene, DNA variant,
No. (%)
Log-linear regression analysis
and genotype
ALL patients
ALL mothers
ALL fathers
Controls
Model
Genotype
Child OR (95% CI)
CDKN2A
rs36228834
Child versus Null
TA versus TT
2.48 (1.45–4.15)
.001
TT
266 (86.6)
160 (93.0)
149 (86.6)
298 (93.7)
AA versus TT
9.87 (0.89–109.69)
TA
39 (12.7)
12 (7.0)
22 (12.8)
19 (6.0)
TA/AA versus TT
2.56 (1.54–4.26)
.0005
AA
2 (0.7)
0
1 (0.6)
1 (0.3)
Child + Mother versus Null
TA versus TT
3.13 (1.81–5.40)
.0005
AA versus TT
—
TA/AA versus TT
2.56 (1.54–4.26)
.0005
CDKN2B
rs36229158
Child versus Null
CT versus CC
1.77 (0.98–3.21)
.054
CC
277 (91.4)
164 (95.4)
155 (90.1)
302 (94.7)
TT versus CC
8.25 (0.75–91.3)
CT
24 (7.9)
8 (4.6)
16 (9.3)
16 (5.0)
CT/TT versus CC
1.86 (1.04–3.34)
.037
TT
2 (0.7)
0
1 (0.6)
1 (0.3)
Child + Mother versus Null
CT versus CC
2.32 (1.23–4.35)
.033
TT versus CC
—
CT/TT versus CC
2.44 (1.29–4.60)
.006
Percentages indicate number of individuals with a given genotype/total number of genotyped individuals. Risk estimation was performed using log-linear regression analysis as implemented in the LEM software. Child odd ratios were measured using regression models consisting of the child genotype effect only (Child versus Null) or both child and mother genotypes (Child + Mother versus Null). Mating symmetry (i.e., six mating-type parameters) was assumed at both loci. values of the Wald test provided by LEM are shown for either the 2 degree-of-freedom (2 child genotype effects) or 1 degree-of-freedom (1 child genotype effect resulting from the collapsed heterozygous/homozygous rare genotypes) tests. OR indicates odds ratio; CI: confidence interval.