A Styrene-alt-Maleic Acid Copolymer Is an Effective Inhibitor of R5 and X4 Human Immunodeficiency Virus Type 1 Infection
Figure 5
alt-PSMA effectively inhibits infection of primary human immune cells by HIV-1 strains BaL and IIIB. PBMCs were incubated for 6 h with HIV-1 strains (a) BaL or (b) IIIB in the absence or presence of alt-PSMA, PSS, or DS (as described in Section 2). Infectivity remaining is expressed relative to mock-treated, HIV-1-infected cells. Each concentration was examined in triplicate in two independent assays. (c) PBMCs were exposed (or mock exposed) to the indicated concentrations of alt-PSMA, PSS, or DS for 6 h. Following the exposure period, cells were washed and assessed for viability using an MTS assay (as described in Section 2). Results illustrated are from two independent assays in which each concentration was examined in triplicate.
