Figure 2: Peculiarities of amino acid composition of ID proteins. (a) Comparison of the mean net charge and the mean hydrophobicity for a set of 275 ordered (open circles) and 91 natively unfolded proteins (gray circles). The solid line represents the border between extended IDPs and ordered proteins (see text). (b) Order/disorder composition profile. Comparisons of amino acid compositions of ordered proteins with each of three databases of disordered proteins. The ordinates are (%amino acid in disordered dataset - %amino acid in ordered dataset)/(%amino acid in ordered dataset) = /globular_3D. Names of each database indicate how the disordered regions were identified. Negative values indicate that the disordered database has less than order, positive indicates more than order.
