Methodology Report

Identification of Multiple Hypoxia Signatures in Neuroblastoma Cell Lines by - Regularization and Data Reduction

Table 1

Modulation of gene expression by hypoxia in neuroblastoma cell lines.

cell linegene expression(1)
nameMorphology(2)MYCN amplification(3)up-regulateddown-regulated

ACNneuroblast (N) 14001317
SHEP-2epithelial (S) 16091043
GI-ME-Nneuroblast (N) 762881
SK-N-F1epithelial (S) 12061051
SK-N-SHneuroblast/epithelial (I) 922758
SK-N-BE(2)cneuroblast/epithelial (I) + 8551273
IMR-32neuroblast (N) + 10001077
LAN-1neuroblast (N) + 10611016
GI-LI-Nneuroblast (N) + 15161002

(1)Number of modulated probesets by hypoxia (1%O2for 18 hours). (2)N: neuroblast; S: substrate adherent; I: intermediate [2]. (3)For reference see [2].