Identification of Multiple Hypoxia Signatures in Neuroblastoma Cell Lines by - Regularization and Data Reduction

Table 4

Hypoxia gene signatures overlap and HRE analysis.

Signature^(1)	Gene Name^(2)	HRE^(3)
Apoptosis	BNIP3	9
	BNIP3L	5
	EGLN3	3
	VEGF	4
Glycolysis	ALDOC	3
	PGK1	1
Oxydative Phosphorylation	ATP5G1	2
	ATP5I	5
	ATP5L	0
	ATP6V0B	6
	ATP6V0E	2
	ATP6V0E	2
	ATP6V1B1	0
	ATP6V1D	1
	DDX11	1
	LOC92270	3
	NDUFAF1	1
	NDUFB2	1
	NDUFB3	1
	NDUFB6	1
	NDUFB8	2
	NDUFS1	3
	NDUFS6	9
	NDUFS7	2
	NDUFS8	3
	NDUFS8	3
	NDUFV3	7
	SMEK2	3
	UCRC	2
	UQCRC2	3
All-chip	AK3L1	4
	ALDOC	3
	BNIP3	9
	DDIT4	1
	E2IG5	5
	PDK1	4
	VEGF	4
	WDR5B	3

⁽¹⁾Hypoxia gene signatures. ⁽²⁾Multiple probesets were collapsed to single genes. The genes overlapping with Jögi et al. hypoxia signature are underlined in bold. ⁽³⁾Number of HRE sequences found in the promoter region.