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Linked References

1. A. Jemal, R. Siegel, E. Ward, et al., “Cancer statistics, 2008,” CA: A Cancer Journal for Clinicians, vol. 58, no. 2, pp. 71–96, 2008. View at Publisher · View at Google Scholar · View at PubMed
2. D. M. Parkin, F. Bray, J. Ferlay, and P. Pisani, “Global cancer statistics, 2002,” CA: A Cancer Journal for Clinicians, vol. 55, no. 2, pp. 74–108, 2005.
3. A. D. Chalmers and J. M. W. Slack, “The Xenopus tadpole gut: fate maps and morphogenetic movements,” Development, vol. 127, no. 2, pp. 381–392, 2000.
4. K. D. Tremblay and K. S. Zaret, “Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues,” Developmental Biology, vol. 280, no. 1, pp. 87–99, 2005. View at Publisher · View at Google Scholar · View at PubMed
5. J. Jung, M. Zheng, M. Goldfarb, and K. S. Zaret, “Initiation of mammalian liver development from endoderm by fibroblast growth factors,” Science, vol. 284, no. 5422, pp. 1998–2003, 1999. View at Publisher · View at Google Scholar
6. J. M. Rossi, N. R. Dunn, B. L. M. Hogan, and K. S. Zaret, “Distinct mesodermal signals, including BMPs from the septum, transversum mesenchyme, are required in combination for hepatogenesis from the endoderm,” Genes and Development, vol. 15, no. 15, pp. 1998–2009, 2001. View at Publisher · View at Google Scholar · View at PubMed
7. G. Deutsch, J. Jung, M. Zheng, J. Lóra, and K. S. Zaret, “A bipotential precursor population for pancreas and liver within the embryonic endoderm,” Development, vol. 128, no. 6, pp. 871–881, 2001.
8. D. Shin, C. H. Shin, J. Tucker, et al., “Bmp and Fgf signaling are essential for liver specification in zebrafish,” Development, vol. 134, no. 11, pp. 2041–2050, 2007. View at Publisher · View at Google Scholar · View at PubMed
9. W. Zhang, T. A. Yatskievych, R. K. Baker, and P. B. Antin, “Regulation of Hex gene expression and initial stages of avian hepatogenesis by Bmp and Fgf signaling,” Developmental Biology, vol. 268, no. 2, pp. 312–326, 2004. View at Publisher · View at Google Scholar · View at PubMed
10. V. A. McLin, S. A. Rankin, and A. M. Zorn, “Repression of Wnt/$\beta$-catenin signaling in the anterior endoderm is essential for liver and pancreas development,” Development, vol. 134, no. 12, pp. 2207–2217, 2007. View at Publisher · View at Google Scholar · View at PubMed
11. K. R. Finley, J. Tennessen, and W. Shawlot, “The mouse Secreted frizzled-related protein 5 gene is expressed in the anterior visceral endoderm and foregut endoderm during early post-implantation development,” Gene Expression Patterns, vol. 3, no. 5, pp. 681–684, 2003. View at Publisher · View at Google Scholar
12. S. P. S. Monga, H. K. Monga, X. Tan, K. Mulé, P. Pediaditakis, and G. K. Michalopoulos, “$\beta$-catenin antisense studies in embryonic liver cultures: role in proliferation, apoptosis, and lineage specification,” Gastroenterology, vol. 124, no. 1, pp. 202–216, 2003. View at Publisher · View at Google Scholar · View at PubMed
13. E. A. Ober, H. Verkade, H. A. Field, and D. Y. Stainier, “Mesodermal Wnt2b signalling positively regulates liver specification,” Nature, vol. 442, no. 7103, pp. 688–691, 2006. View at Publisher · View at Google Scholar · View at PubMed
14. R. Bort, M. Signore, K. Tremblay, J. P. Martinez Barbera, and K. S. Zaret, “Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development,” Developmental Biology, vol. 290, no. 1, pp. 44–56, 2006. View at Publisher · View at Google Scholar · View at PubMed
15. F. P. Lemaigre, “Mechanisms of liver development: concepts for understanding liver disorders and design of novel therapies,” Gastroenterology, vol. 137, no. 1, pp. 62–79, 2009. View at Publisher · View at Google Scholar · View at PubMed
16. J. P. Martinez Barbera, M. Clements, P. Thomas, et al., “The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation,” Development, vol. 127, no. 11, pp. 2433–2445, 2000.
17. V. W. Keng, H. Yagi, M. Ikawa, et al., “Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage,” Biochemical and Biophysical Research Communications, vol. 276, no. 3, pp. 1155–1161, 2000. View at Publisher · View at Google Scholar · View at PubMed
18. R. Zhao, A. J. Watt, J. Li, J. Luebke-Wheeler, E. E. Morrisey, and S. A. Duncan, “GATA6 is essential for embryonic development of the liver but dispensable for early heart formation,” Molecular and Cellular Biology, vol. 25, no. 7, pp. 2622–2631, 2005. View at Publisher · View at Google Scholar · View at PubMed
19. S. Margagliotti, F. Clotman, C. E. Pierreux, et al., “The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration,” Developmental Biology, vol. 311, no. 2, pp. 579–589, 2007. View at Publisher · View at Google Scholar · View at PubMed
20. T. H.-W. Lüdtke, V. M. Christoffels, M. Petry, and A. Kispert, “Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation,” Hepatology, vol. 49, no. 3, pp. 969–978, 2009. View at Publisher · View at Google Scholar · View at PubMed
21. B. Sosa-Pineda, J. T. Wigle, and G. Oliver, “Hepatocyte migration during liver development requires Prox1,” Nature Genetics, vol. 25, no. 3, pp. 254–255, 2000. View at Publisher · View at Google Scholar · View at PubMed
22. C. Schmidt, F. Bladt, S. Goedecke, et al., “Scatter factor/hepatocyte growth factor is essential for liver development,” Nature, vol. 373, no. 6516, pp. 699–702, 1995.
23. N. Tanimizu and A. Miyajima, “Molecular mechanism of liver development and regeneration,” International Review of Cytology, vol. 259, pp. 1–48, 2007. View at Publisher · View at Google Scholar · View at PubMed
24. M. Weinstein, S. P. S. Monga, Y. Liu, et al., “Smad proteins and hepatocyte growth factor control parallel regulatory pathways that converge on $\beta$1-integrin to promote normal liver development,” Molecular and Cellular Biology, vol. 21, no. 15, pp. 5122–5131, 2001. View at Publisher · View at Google Scholar · View at PubMed
25. R. Zhao and S. A. Duncan, “Embryonic development of the liver,” Hepatology, vol. 41, no. 5, pp. 956–967, 2005. View at Publisher · View at Google Scholar · View at PubMed
26. K. Matsumoto, H. Yoshitomi, J. Rossant, and K. S. Zaret, “Liver organogenesis promoted by endothelial cells prior to vascular function,” Science, vol. 294, no. 5542, pp. 559–563, 2001. View at Publisher · View at Google Scholar · View at PubMed
27. E. Lammert, O. Cleaver, and D. Melton, “Role of endothelial cells in early pancreas and liver development,” Mechanisms of Development, vol. 120, no. 1, pp. 59–64, 2003. View at Publisher · View at Google Scholar
28. K. Matsumoto, R. Miki, M. Nakayama, N. Tatsumi, and Y. Yokouchi, “Wnt9a secreted from the walls of hepatic sinusoids is essential for morphogenesis, proliferation, and glycogen accumulation of chick hepatic epithelium,” Developmental Biology, vol. 319, no. 2, pp. 234–247, 2008. View at Publisher · View at Google Scholar · View at PubMed
29. S. Suksaweang, C.-M. Lin, T.-X. Jiang, M. W. Hughes, R. B. Widelitz, and C.-M. Chuong, “Morphogenesis of chicken liver: identification of localized growth zones and the role of $\beta$-catenin/Wnt in size regulation,” Developmental Biology, vol. 266, no. 1, pp. 109–122, 2004. View at Publisher · View at Google Scholar
30. F. Lemaigre and K. S. Zaret, “Liver development update: new embryo models, cell lineage control, and morphogenesis,” Current Opinion in Genetics and Development, vol. 14, no. 5, pp. 582–590, 2004. View at Publisher · View at Google Scholar · View at PubMed
31. K. S. Zaret, “Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation,” Nature Reviews Genetics, vol. 9, no. 5, pp. 329–340, 2008. View at Publisher · View at Google Scholar · View at PubMed
32. L. Germain, M.-J. Blouin, and N. Marceau, “Biliary epithelial and hepatocytic cell lineage relationships in embryonic rat liver as determined by the differential expression of cytokeratins, $\alpha$-fetoprotein, albumin, and cell surface-exposed components,” Cancer Research, vol. 48, no. 17, pp. 4909–4918, 1988.
33. B. McCright, J. Lozier, and T. Gridley, “A mouse model of Alagille syndrome: notch2 as a genetic modifier of Jag1 haploinsufficiency,” Development, vol. 129, no. 4, pp. 1075–1082, 2002.
34. N. Tanimizu and A. Miyajima, “Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors,” Journal of Cell Science, vol. 117, no. 15, pp. 3165–3174, 2004. View at Publisher · View at Google Scholar · View at PubMed
35. A. Suzuki, A. Iwana, H. Miyashita, H. Nakauchi, and H. Taniguchi, “Role for growth factors and extracellular matrix in controlling differentiation of prospectively isolated hepatic stem cells,” Development, vol. 130, no. 11, pp. 2513–2524, 2003. View at Publisher · View at Google Scholar
36. A. Jochheim, A. Cieslak, T. Hillemann, et al., “Multi-stage analysis of differential gene expression in BALB/C mouse liver development by high-density microarrays,” Differentiation, vol. 71, no. 1, pp. 62–72, 2003. View at Publisher · View at Google Scholar
37. N. Kelley-Loughnane, G. E. Sabla, C. Ley-Ebert, B. J. Aronow, and J. A. Bezerra, “Independent and overlapping transcriptional activation during liver development and regeneration in mice,” Hepatology, vol. 35, no. 3, pp. 525–534, 2002. View at Publisher · View at Google Scholar · View at PubMed
38. P. M. Petkov, J. Zavadil, D. Goetz, et al., “Gene expression pattern in hepatic stem/progenitor cells during rat fetal development using complementary DNA microarrays,” Hepatology, vol. 39, no. 3, pp. 617–627, 2004. View at Publisher · View at Google Scholar · View at PubMed
39. T. Watanabe, K. Nakagawa, S. Ohata, et al., “SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-$\kappa$B-induced anti-apoptosis,” Developmental Biology, vol. 250, no. 2, pp. 332–347, 2002. View at Publisher · View at Google Scholar
40. I. Takashimizu, Y. Tanaka, S. Yoshie, et al., “Localization of Liv2 as an immature hepatocyte marker in EB outgrowth,” The Scientific World Journal, vol. 9, pp. 190–199, 2009. View at Publisher · View at Google Scholar · View at PubMed
41. M. Nitou, Y. Sugiyama, K. Ishikawa, and N. Shiojiri, “Purification of fetal mouse hepatoblasts by magnetic beads coated with monoclonal anti-E-cadherin antibodies and their in vitro culture,” Experimental Cell Research, vol. 279, no. 2, pp. 330–343, 2002. View at Publisher · View at Google Scholar
42. N. Tanimizu, M. Nishikawa, H. Saito, T. Tsujimura, and A. Miyajima, “Isolation of hepatoblasts based on the expression of Dlk/Pref-1,” Journal of Cell Science, vol. 116, no. 9, pp. 1775–1786, 2003. View at Publisher · View at Google Scholar
43. M. Inada, D. Benten, K. Cheng, et al., “Stage-specific regulation of adhesion molecule expression segregates epithelial stem/progenitor cells in fetal and adult human livers,” Hepatology International, vol. 2, no. 1, pp. 50–62, 2008. View at Publisher · View at Google Scholar · View at PubMed
44. J. D. Terrace, I. S. Currie, D. C. Hay, et al., “Progenitor cell characterization and location in the developing human liver,” Stem Cells and Development, vol. 16, no. 5, pp. 771–778, 2007. View at Publisher · View at Google Scholar · View at PubMed
45. E. Schmelzer, L. Zhang, A. Bruce, et al., “Human hepatic stem cells from fetal and postnatal donors,” Journal of Experimental Medicine, vol. 204, no. 8, pp. 1973–1987, 2007. View at Publisher · View at Google Scholar · View at PubMed
46. J. D. Terrace, D. C. Hay, K. Samuel, et al., “Side population cells in developing human liver are primarily haematopoietic progenitor cells,” Experimental Cell Research, vol. 315, no. 13, pp. 2141–2153, 2009. View at Publisher · View at Google Scholar · View at PubMed
47. M. A. Goodell, S. McKinney-Freeman, and F. D. Camargo, “Isolation and characterization of side population cells,” Methods in Molecular Biology, vol. 290, pp. 343–352, 2005.
48. T. Plösch, A. Kosters, A. K. Groen, and F. Kuipers, “The ABC of hepatic and intestinal cholesterol transport,” Handbook of Experimental Pharmacology, no. 170, pp. 465–482, 2005.
49. S. J. Forbes and M. R. Alison, “Side population (SP) cells: taking center stage in regeneration and liver cancer?” Hepatology, vol. 44, no. 1, pp. 23–26, 2006. View at Publisher · View at Google Scholar · View at PubMed
50. N. Fausto, J. S. Campbell, and K. J. Riehle, “Liver regeneration,” Hepatology, vol. 43, no. 2, supplement 1, pp. 45–53, 2006. View at Publisher · View at Google Scholar · View at PubMed
51. G. K. Michalopoulos and M. C. DeFrances, “Liver regeneration,” Science, vol. 276, no. 5309, pp. 60–66, 1997.
52. X. Wang, M. Foster, M. Al-Dhalimy, E. Lagasse, M. Finegold, and M. Grompe, “The origin and liver repopulating capacity of murine oval cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, supplement 1, pp. 11881–11888, 2003. View at Publisher · View at Google Scholar · View at PubMed
53. D. Rosenberg, Z. Ilic, L. I. Yin, and S. Sell, “Proliferation of hepatic lineage cells of normal C57BL and interleukin-6 knockout mice after cocaine-induced periportal injury,” Hepatology, vol. 31, no. 4, pp. 948–955, 2000.
54. H. H. Otu, K. Naxerova, K. Ho, et al., “Restoration of liver mass after injury requires proliferative and not embryonic transcriptional patterns,” Journal of Biological Chemistry, vol. 282, no. 15, pp. 11197–11204, 2007. View at Publisher · View at Google Scholar · View at PubMed
55. L. Zhang, N. Theise, M. Chua, and L. M. Reid, “The stem cell niche of human livers: symmetry between development and regeneration,” Hepatology, vol. 48, no. 5, pp. 1598–1607, 2008. View at Publisher · View at Google Scholar · View at PubMed
56. T. G. Fellous, S. Islam, P. J. Tadrous, et al., “Locating the stem cell niche and tracing hepatocyte lineages in human liver,” Hepatology, vol. 49, no. 5, pp. 1655–1663, 2009. View at Publisher · View at Google Scholar · View at PubMed
57. T. G. Bird, S. Lorenzini, and S. J. Forbes, “Activation of stem cells in hepatic diseases,” Cell and Tissue Research, vol. 331, no. 1, pp. 283–300, 2008. View at Publisher · View at Google Scholar · View at PubMed
58. P. Nagy, H. C. Bisgaard, E. Santoni-Rugiu, and S. S. Thorgeirsson, “In vivo infusion of growth factors enhances the mitogenic response of rat hepatic ductal (oval) cells after administration of 2-acetylaminofluorene,” Hepatology, vol. 23, no. 1, pp. 71–79, 1996. View at Publisher · View at Google Scholar
59. S. Hasuike, A. Ido, H. Uto, et al., “Hepatocyte growth factor accelerates the proliferation of hepatic oval cells and possibly promotes the differentiation in a 2-acetylaminofluorene/partial hepatectomy model in rats,” Journal of Gastroenterology and Hepatology, vol. 20, no. 11, pp. 1753–1761, 2005. View at Publisher · View at Google Scholar · View at PubMed
60. H. Oe, T. Kaido, A. Mori, H. Onodera, and M. Imamura, “Hepatocyte growth factor as well as vascular endothelial growth factor gene induction effectively promotes liver regeneration after hepatectomy in Solt-Farber rats,” Hepato-Gastroenterology, vol. 52, no. 65, pp. 1393–1397, 2005.
61. R. J. Isfort, D. B. Cody, S. B. Stuard, et al., “The combination of epidermal growth factor and transforming growth factor-beta induces novel phenotypic changes in mouse liver stem cell lines,” Journal of Cell Science, vol. 110, no. 24, pp. 3117–3129, 1997.
62. L. N. Nguyen, M. H. Furuya, L. A. Wolfraim, et al., “Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation,” Hepatology, vol. 45, no. 1, pp. 31–41, 2007. View at Publisher · View at Google Scholar · View at PubMed
63. V. B. Matthews, B. Knight, J. E. E. Tirnitz-Parker, J. Boon, J. K. Olynyk, and G. C. T. Yeoh, “Oncostatin M induces an acute phase response but does not modulate the growth or maturation-status of liver progenitor (oval) cells in culture,” Experimental Cell Research, vol. 306, no. 1, pp. 252–263, 2005. View at Publisher · View at Google Scholar · View at PubMed
64. U. Apte, S. Singh, G. Zeng, et al., “Beta-catenin activation promotes liver regeneration after acetaminophen-induced injury,” American Journal of Pathology, vol. 175, no. 3, pp. 1056–1065, 2009. View at Publisher · View at Google Scholar · View at PubMed
65. T. Itoh, Y. Kamiya, M. Okabe, M. Tanaka, and A. Miyajima, “Inducible expression of Wnt genes during adult hepatic stem/progenitor cell response,” FEBS Letters, vol. 583, no. 4, pp. 777–781, 2009. View at Publisher · View at Google Scholar · View at PubMed
66. B. Knight, J. E. E. Tirnitz-Parker, and J. K. Olynyk, “C-kit inhibition by imatinib mesylate attenuates progenitor cell expansion and inhibits liver tumor formation in mice,” Gastroenterology, vol. 135, no. 3, pp. 969.e1–979.e1, 2008. View at Publisher · View at Google Scholar · View at PubMed
67. T. C. McDevitt and S. P. Palecek, “Innovation in the culture and derivation of pluripotent human stem cells,” Current Opinion in Biotechnology, vol. 19, no. 5, pp. 527–533, 2008. View at Publisher · View at Google Scholar · View at PubMed
68. D. M. Dalgetty, C. N. Medine, J. P. Iredale, and D. C. Hay, “Progress and future challenges in stem cell-derived liver technologies,” American Journal of Physiology, vol. 297, no. 2, pp. G241–G248, 2009. View at Publisher · View at Google Scholar · View at PubMed
69. http://www.britishlivertrust.org.uk/modules/news/StoryViewer.aspx?pid=6&intextraid=2303&fid=2007.
70. A. S. Befeler and A. M. Di Bisceglie, “Hepatocellular carcinoma: diagnosis and treatment,” Gastroenterology, vol. 122, no. 6, pp. 1609–1619, 2002.
71. S. Sell and H. L. Leffert, “An evaluation of cellular lineages in the pathogenesis of experimental hepatocellular carcinoma,” Hepatology, vol. 2, no. 1, pp. 77–86, 1982.
72. S. Sell and H. L. Leffert, “Liver cancer stem cells,” Journal of Clinical Oncology, vol. 26, no. 17, pp. 2800–2805, 2008. View at Publisher · View at Google Scholar · View at PubMed
73. T. Chiba, A. Kamiya, O. Yokosuka, and A. Iwama, “Cancer stem cells in hepatocellular carcinoma: recent progress and perspective,” Cancer Letters, vol. 286, no. 2, pp. 145–153, 2009. View at Publisher · View at Google Scholar · View at PubMed
74. K. Aterman, “Hepatic neoplasia: reflections and ruminations,” Virchows Archiv, vol. 427, no. 1, pp. 1–18, 1995.
75. V. R. Potter, “Recent trends in cancer biochemistry: the importance of studies on fetal tissue,” in Proceedings of the 8th Canadian Cancer Conference, vol. 8, pp. 9–30, Ontario, Canada, 1969.
76. V. R. Potter, “Phenotypic diversity in experimental hepatomas: the concept of partially blocked ontogeny,” British Journal of Cancer, vol. 38, no. 1, pp. 1–23, 1978, The 10th Walter Hubert Lecture.
77. V. R. Potter, “The present status of the blocked ontogeny hypothesis of neoplasia: the thalassemia connection,” Oncodevelopmental Biology and Medicine, vol. 2, no. 4, pp. 243–266, 1981.
78. M. R. Alison and M. J. Lovell, “Liver cancer: the role of stem cells,” Cell Proliferation, vol. 38, no. 6, pp. 407–421, 2005. View at Publisher · View at Google Scholar · View at PubMed
79. M. L. Dumble, E. J. Croager, G. C. T. Yeoh, and E. A. Quail, “Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma,” Carcinogenesis, vol. 23, no. 3, pp. 435–445, 2002.
80. P. Steinberg, R. Steinbrecher, S. Radaeva, et al., “Oval cell lines OC/CDE 6 and OC/CDE 22 give rise to cholangio-cellular and undifferentiated carcinomas after transformation,” Laboratory Investigation, vol. 71, no. 5, pp. 700–709, 1994.
81. N. D. Theise, J. L. Yao, K. Harada, et al., “Hepatic ‘stem cell’ malignancies in adults: four cases,” Histopathology, vol. 43, no. 3, pp. 263–271, 2003. View at Publisher · View at Google Scholar
82. J.-S. Lee, J. Heo, L. Libbrecht, et al., “A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells,” Nature Medicine, vol. 12, no. 4, pp. 410–416, 2006. View at Publisher · View at Google Scholar · View at PubMed
83. A. Suzuki, S. Sekiya, M. Onishi, et al., “Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver,” Hepatology, vol. 48, no. 6, pp. 1964–1978, 2008. View at Publisher · View at Google Scholar · View at PubMed
84. T. Chiba, K. Kita, Y.-W. Zheng, et al., “Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties,” Hepatology, vol. 44, no. 1, pp. 240–251, 2006. View at Publisher · View at Google Scholar · View at PubMed
85. T. Yamashita, J. Ji, A. Budhu, et al., “EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features,” Gastroenterology, vol. 136, no. 3, pp. 1012–1024, 2009. View at Publisher · View at Google Scholar · View at PubMed
86. T. Yamashita, M. Forgues, W. Wang, et al., “EpCAM and $\alpha$-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma,” Cancer Research, vol. 68, no. 5, pp. 1451–1461, 2008. View at Publisher · View at Google Scholar · View at PubMed
87. W. Yang, H.-X. Yan, L. Chen, et al., “Wnt/$\beta$-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells,” Cancer Research, vol. 68, no. 11, pp. 4287–4295, 2008. View at Publisher · View at Google Scholar · View at PubMed
88. T. Yamashita, A. Budhu, M. Forgues, and W. W. Xin, “Activation of hepatic stem cell marker EpCAM by Wnt-$\beta$-catenin signaling in hepatocellular carcinoma,” Cancer Research, vol. 67, no. 22, pp. 10831–10839, 2007. View at Publisher · View at Google Scholar · View at PubMed
89. Y. Tang, K. Kitisin, W. Jogunoori, et al., “Progenitor/stem cells give rise to liver cancer due to aberrant TGF-$\beta$ and IL-6 signaling,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 7, pp. 2445–2450, 2008. View at Publisher · View at Google Scholar · View at PubMed
90. M. A. Chaudry, K. Sales, P. Ruf, H. Lindhofer, and M. C. Winslet, “EpCAM an immunotherapeutic target for gastrointestinal malignancy: current experience and future challenges,” British Journal of Cancer, vol. 96, no. 7, pp. 1013–1019, 2007. View at Publisher · View at Google Scholar · View at PubMed
91. C. M. Shachaf, A. M. Kopelman, C. Arvanitis, et al., “MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer,” Nature, vol. 431, no. 7012, pp. 1112–1117, 2004. View at Publisher · View at Google Scholar · View at PubMed
92. L. Mishra, T. Banker, J. Murray, et al., “Liver stem cells and hepatocellular carcinoma,” Hepatology, vol. 49, no. 1, pp. 318–329, 2009. View at Publisher · View at Google Scholar · View at PubMed
93. M. Kin, T. Torimura, T. Ueno, S. Inuzuka, and K. Tanikawa, “Sinusoidal capillarization in small hepatocellular carcinoma,” Pathology International, vol. 44, no. 10-11, pp. 771–778, 1994.
94. Y. N. Park, C.-P. Yang, G. J. Fernandez, O. Cubukcu, S. N. Thung, and N. D. Theise, “Neoangiogenesis and sinusoidal “capillarization ” in dysplastic nodules of the liver,” American Journal of Surgical Pathology, vol. 22, no. 6, pp. 656–662, 1998. View at Publisher · View at Google Scholar
95. M. B. Thomas, J. S. Morris, R. Chadha, et al., “Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma,” Journal of Clinical Oncology, vol. 27, no. 6, pp. 843–850, 2009. View at Publisher · View at Google Scholar · View at PubMed
96. L. Rimassa and A. Santoro, “Sorafenib therapy in advanced hepatocellular carcinoma: the SHARP trial,” Expert Review of Anticancer Therapy, vol. 9, no. 6, pp. 739–745, 2009. View at Publisher · View at Google Scholar · View at PubMed