|
| Allergy model | Suppressive mechanism | Reference |
|
Defined helminth molecules; (from helminth species) | | | |
|
smCKBP; (S. mansoni) | Hapten-induced contact hypersensitivity | NA3 | [27] |
|
Sm22.6, PIII and Sm29; (S. mansoni) | OVA-induced AI1 | CD4+Foxp3+ Treg | [65] |
|
As-MIF; (A. simplex) | OVA-induced AI | IL-10, TGF-β, and Treg dependent | [66] |
|
PAS-1; (A. suum) | APAS-3-induced AI | Possibly IL-10 | [67] |
OVA-induced AHR2 | CD4+CD25+ T cell-, CD8+ T cell-dependent and IL-10/TGF-β-, IFN-γ-mediated | [68, 69] |
|
Nippocystatin (NbCys); (N. brasiliensis) | OVA-induced AI | Cathepsin B and cathepsin L-dependent mechanism | [70] |
|
AvCystatin (Av17); (A. viteae) | OVA-induced AHR | IL-10, macrophages, partially CD4+CD25+ T cells | [71] |
|
ES-62; (A. viteae) | Oxazolone- (Oxa-) induced skin immediate hypersensitivity OVA-induced AHR | Mast cell mediated, TLR4-dependent | [72] |
|
Helminth infection and undefined products | | | |
|
S. mansoni infection; males and females + eggs laid in infection; males (no eggs) | Pen V-induced systemic anaphylaxis | IL-10-producing B cells | [73] |
|
S. mansoni infection; males (no eggs) | OVA-induced AHR | B cell- and IL-10-dependent suppression of pulmonary eosinophil infiltration | [74] |
|
S. mansoni infection; eggs | OVA-induced AI | Egg-treatment: CD4+CD25+Foxp3+Treg | [75] |
|
S. japonicum egg antigen (SEA) | OVA-induced AI | CD4+CD25+ Treg, possibly IL-10 | [76] |
|
A. suum adult worm extract (ASC) | OVA-induced AHR | NA | [77] |
|
Heligmosomoides polygyrus infection | OVA-induced AHR | IL-10 | [78] |
OVA-induced AHR HDM-induced AI | IL-10-independent, CD4+CD25+ T cells IL-10-independent Breg cells | [79, 80] |
Peanut extract-induced food allergy | IL-10 | [81] |
|
H. polygyrus excretory-secretory product (HES) | OVA-induced AI | HES-induced Treg cells | [82] |
|
N. brasiliensis infection | OVA-induced AHR | IL-10 from unknown cell source | [83] |
|
N. brasiliensis excretory-secretory product (NES) | OVA-induced AI | NA (IL-10 independent) | [84] |
|
Strongyloides stercoralis infection | OVA-induced AI | NA | [85] |
|
Strongyloides venezuelensis infection | OVA-induced AI | NA | [86] |
|
T. spiralis infection | OVA-induced AI | Correlated with increased IL-10, TGF-β, CD4+CD25+ Treg | [87] |
|
L. sigmodontis infection | OVA-induced AHR | TGF-β, CD4+CD25+ Treg | [88] |
|