Review Article
Autism Spectrum Disorders: Is Mesenchymal Stem Cell Personalized Therapy the Future?
Table 1
Potential ameliorative effects mediated by MSCs in ASD treatment.
| ASD-induced changes in human brain | Potential MSC ameliorative roles seen in preclinical models |
| Abnormal functioning | Improving functional recovery | Cerebellum alterations | Integrating in altered brain and restoring damaged functions | Decreased number of Purkinje cells (PCs) | Restoring cerebellar PCs | Defective cortical organization | Reinforcing cortical plasticity | Altered plasticity of dendritic spine morphology | Promoting synaptic plasticity |
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