Effects of IRF5 Lupus Risk Haplotype on Pathways Predicted to Influence B Cell Functions
Figure 3
Association of the canonical B-cell receptor pathway with IRF5 haplotype. BCR pathway genes demonstrate a significant enrichment of changes in expression levels based on IRF5 haplytype, as determined by Ingenuity analysis (). The unstimulated condition is shown on the left, and the EBV-exposed condition is shown on the right. Genes with altered expression based on haplotype are shown as either blue or red. BLNK: B cell linker, CAM: Calmodulin, CN: Calcineurin, ERK: extracellular signal-regulated kinase, FCGR2B: fragment crystallizable γ receptor 2B, INPP5D: inositol polyphosphate-5-phosphatase D (SHIP), MALT1: mucosa associated lymphoid tissue lymphoma translocation gene 1, and PKC: protein kinase C.
