Soluble Host Defense Lectins in Innate Immunity to Influenza Virus

Table 1

Comparison of monosaccharide specificity of animal lectins with anti-IAV activity.

Lectin^a	Family	Monosaccharide preferences^b	Binding to IAV
hSP-D	C-type	L-Fuc > Mann > Gluc > Gal > GlcNAc [142]	Yes
hMBL	C-type	GlcNAc > L-Fuc, Mann > ManNAc > Gluc > GalNAc [74]	Yes
hCL-L1	C-type	Mann = L-Fuc = Gal > GlcNAc > GalNAc [94]	—
hCL-K1	C-type	L-Fuc > Mann > ManNAc > GlcNAc > Gal [96]	Yes
bConglutinin	C-type	GlcNAc > Mann, L-Fuc > Gluc > ManNAc > GalNAc [74]	Yes
bCL-43	C-type	Mann > ManNAc > L-Fuc > GlcNAc > Gluc > GalNAc [112]	Yes
bCL-46	C-type	GlcNAc > ManNAc > Mann, Gluc, L-Fuc > Gal [143]	Yes
hGalectin-1	S-type	Gal > GalNAc > GlcNAc, Mann [144]	Yes
hSAP	Pentraxin	Mann > GlcNAc > L-Fuc, Gal, GalNAc [32]	Yes

^aData reported for human (h) or bovine (b) lectins as indicated.
^bAbbreviation of monosaccharides: L-Fuc: L-fucose; Mann: D-mannose; Gal: D-galactose; ManNAc: N-acetyl-D-mannosamine; GlcNAc: N-acetyl-D-glucosamine; GalNAc: N-acetyl-D-galactosamine.
—: not reported to date.