Soluble Host Defense Lectins in Innate Immunity to Influenza Virus

Table 3

Virulence of different IAVs in mice genetically deficient in particular animal lectins.

Mice deficient in	IAV strain^a	Susceptibility to IAV infection	Virus growth in lungs	Comments	References
SP-D	Phil/82	↑	↑	↑ lung inflammation	[47, 48]
	Phil/82Δ167	ND	ND	Lacking Asn165 = less sensitive to SP-D	[47]
	Mem71	ND	ND	Strain less sensitive to SP-D than Phil/82	[48]
MBL-A/C	Phil/82	↑	↑	↑ inflammation and lung injury	[84]
	Cal/09	↓	ND	↓ inflammation and lung injury	[93]
	H9N2/G1	↓	↓	↓ inflammation and lung injury	[93]
Galectin-1	WSN/33	↑	—	HI and neutralization against IAV in vitro	[28]
SAP	PR8, WS/33, Shg/24	ND	ND	HI and neutralization against IAV in vitro	[133]

^aIAV strains used: A/Philippines/82 (Phil/82, H3N2); A/Mem71_H-Bel_N (Mem/71, H3N1); A/WSN/33 (WSN/33, H1N1); A/PR/8/34 (PR8, H1N1), A/WS/33 (WS/33, H1N1), A/California/04/09 (Cal/09, H1N1 pdm), A/Shanghai/24/90 (Shg/24, H3N2), A/Quail/Hong Kong/61/97 (H9N2/G1).
↑, ↓, or ND: increased, decreased, or not different to wild-type mice, respectively.
—: not reported to date.