Regulatory RNomics and Gene Expression
Call for Papers
microRNA (miRNA) & small interfering RNA (siRNA) research has marked a newparadigm of small regulatory RNA-directed gene expression modulation in a wide spectrum ofbiological systems. With the generation of a huge amount of sequences from a number of keyorganisms and complementary development of computational biotools for these, smallregulatory RNA annotation and analysis have accelerated this field of research.
This special issue focuses on the major developments in the field of smallregulatory RNAs (especially, miRNomics and siRNomics) in past years and how this promisingnew approach of posttranscriptional gene silencing aims towards revolutionizing the treatmentof various diseases. Emphasis shall be laid towards harnessing the immense potential of smallregulatory RNA research to bridge the gap between biological knowledge and clinical therapy.It highlights computational biology as a powerful tool for analyzing, predicting, andunderstanding these small regulatory RNA genes, their expression and therapeutic potentials,complemented by experimental approaches.
Authors are invited to present original research articles and review articles that address all aspects related to Regulatory RNomics and Gene Expression. Specific topics include but are not limited to:
- Biogenesis, Function and Evolution of small regulatory RNAs
- Biogenesis, structure, and function of small regulatory RNAs
- Role and mechanism of action of small regulatory RNAs in gene regulation
- Evolution of microRNA function across large evolutionary distances
- Novel small regulatory RNAs (miRNA, siRNA, rasiRNA, piRNA, etc.) in parasites, plants and other systems
- Algorithms, Methods and Data mining related to small regulatory RNAs
- Computational challenges in microRNA and its target predictions
- Tools and technologies for miRNA and siRNA analysis
- Data mining methods and databases for regulatory RNAs and their targets
- miRNA and siRNA resources
- Therapeutic implication of small regulatory RNAs
- Small regulatory RNAs as diagnostic biomarkers
- RNAi and siRNA libraries in genome-wide functional studies
- Role of microRNA in metabolic pathways
- microRNAs in human health and disease
- siRNA therapeutics
- RNAi in drug target discovery and validation
Authors should follow the Journal of Biomedicine and Biotechnology manuscript format described at the journal site http://www.hindawi.com/journals/jbb/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/, according to the following timetable:
| Manuscript Due | January 1, 2009 |
| First Round of Reviews | April 1, 2009 |
| Publication Date | July 1, 2009 |
Guest Editors
- Zhumur Ghosh, Computational Biology Group, Indian Association for the Cultivation of Science, Jadavpur, Calcutta 700032, India
- Bibekanand Mallick, Computational Biology Group, Indian Association for the Cultivation of Science, Jadavpur, Calcutta 700032, India
- Daniel Gautheret, CNRS Institut de Génétique et Microbiologie UMR 8621, Université Paris Sud, 91405 Orsay Cedex, France
- Pawan Malhotra, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110 067, India
- Ravi Sachidanandam, Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, NY 10029, USA