Amyotrophic Lateral Sclerosis and Metabolomics: Clinical Implication and Therapeutic Approach
Figure 1
(a) Representative serum NMR spectra of control subjects and ALS patients, (b) and (c) show imbalance between oxidative/antioxidant and glutamate/gluatamine cycle. It has been speculated that glutamate excitotoxicty exacerbates the formation of ROS, which may be responsible for the oxidant-antioxidant imbalance, such as increased BHBT and acetone and decreased concentrations of histidine [26].
