Population-Sequencing as a Biomarker for Sample Characterization

Figure 5

It compares read 𝑛-mers to reference genome 𝑛-mers and counts the number of hits per genome 𝑛-mer (signal) and misses (noise). The separation between signal and noise varies with read depth. The detection threshold that maximizes signal 𝑛-mer retention and noise 𝑛-mer rejection is to be used, and will vary with number of total reads (coverage).