Biomarkers for Detection and Monitoring of B16 Melanoma in Mouse Urine and Feces

Table 4

VOCs with higher concentrations in the urine of tumor-bearing mice than of healthy mice.

Number	RT (min)	Fold (%)	value^1
			H-C	H-E	H-L	E-L
1	6.21	199	0.03	<0.01	0.01	0.01
2	6.67	170	<0.01	<0.01	<0.01	<0.01
3	8.58	212	<0.01	<0.01	<0.01	0.43
4	8.90	265	0.02	—^2	0.02	—^2
5	10.79	200	0.01	0.92	<0.01	0.26
6	11.23	218	0.03	<0.01	0.14	0.03
7	12.44	173	<0.01	0.03	<0.01	0.24
8	13.39	175	<0.01	<0.01	0.06	0.04
9	14.95	124	0.36	<0.01	0.28	<0.01
10	15.30	131	0.04	0.09	0.03	0.43
11	15.51	144	<0.01	0.04	<0.01	0.07
12	16.76	173	0.03	0.05	0.16	0.13
13	16.95	143	<0.01	<0.01	<0.01	0.17

Calculated with a two-tailed paired -test. values smaller than 0.05 are marked in bold. H: healthy; E: early-melanoma; L: late melanoma; C: cancer; both E and L.
²This compound was not detected in mice bearing an early melanoma.