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Linked References

1. N. Armstrong and E. Gouaux, “Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core,” Neuron, vol. 28, no. 1, pp. 165–181, 2000. View at Publisher · View at Google Scholar
2. G.-Q. Chen, Y. U. Sun, R. Jin, and E. Gouaux, “Probing the ligand binding domain of the GluR2 receptor by proteolysis and deletion mutagenesis defines domain boundaries and yields a crystallizable construct,” Protein Science, vol. 7, no. 12, pp. 2623–2630, 1998.
3. G.-Q. Chen and E. Gouaux, “Overexpression of a glutamate receptor (GluR2) ligand binding domain in Escherichia coli: application of a novel protein folding screen,” Proceedings of the National Academy of Sciences of the United States of America, vol. 94, no. 25, pp. 13431–13436, 1997. View at Publisher · View at Google Scholar
4. H. Furukawa and E. Gouaux, “Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core,” The EMBO Journal, vol. 22, no. 12, pp. 2873–2885, 2003. View at Publisher · View at Google Scholar · View at PubMed
5. L. Stoll, S. Seguin, and L. Gentile, “Tricyclic antidepressants, but not the selective serotonin reuptake inhibitor fluoxetine, bind to the S1S2 domain of AMPA receptors,” Archives of Biochemistry and Biophysics, vol. 458, no. 2, pp. 213–219, 2007. View at Publisher · View at Google Scholar · View at PubMed
6. L. Stoll and L. Gentile, “Linking tricyclic antidepressants to ionotropic glutamate receptors,” Biochemical and Biophysical Research Communications, vol. 333, no. 2, pp. 622–627, 2005. View at Publisher · View at Google Scholar · View at PubMed
7. I. J. Reynolds and R. J. Miller, “Tricyclic antidepressants block N-methyl-D-aspartate receptors: similarities to the action of zinc,” British Journal of Pharmacology, vol. 95, no. 1, pp. 95–102, 1988.
8. E. Sernagor, D. Kuhn, L. Vyklicky, Jr., and M. L. Mayer, “Open channel block of NMDA receptor responses evoked by tricyclic antidepressants,” Neuron, vol. 2, no. 3, pp. 1221–1227, 1989. View at Publisher · View at Google Scholar
9. D. Bleakman, A. Alt, and J. M. Witkin, “AMPA receptors in the therapeutic management of depression,” CNS & Neurological Disorders-Drug Targets, vol. 6, no. 2, pp. 117–126, 2007. View at Publisher · View at Google Scholar
10. P. Svenningsson, E. T. Tzavara, J. M. Witkin, A. A. Fienberg, G. G. Nomikos, and P. Greengard, “Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac),” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 5, pp. 3182–3187, 2002. View at Publisher · View at Google Scholar · View at PubMed
11. J. C. Quirk and E. S. Nisenbaum, “LY404187: a novel positive allosteric modulator of AMPA receptors,” CNS Drug Reviews, vol. 8, no. 3, pp. 255–282, 2002.
12. R. Jin, S. Clark, A. M. Weeks, J. T. Dudman, E. Gouaux, and K. M. Partin, “Mechanism of positive allosteric modulators acting on AMPA receptors,” Journal of Neuroscience, vol. 25, no. 39, pp. 9027–9036, 2005. View at Publisher · View at Google Scholar · View at PubMed
13. G. Sanacora, R. Gueorguieva, C. N. Epperson, et al., “Subtype-specific alterations of $\gamma$-aminobutyric acid and glutamate in patients with major depression,” Archives of General Psychiatry, vol. 61, no. 7, pp. 705–713, 2004. View at Publisher · View at Google Scholar · View at PubMed
14. D. Sheehan, Physical Biochemistry: Principles and Applications, John Wiley & Sons, Chichester, UK, 2000.
15. J. R. Lakowicz, Principles of Fluorescence Spectroscopy, Kluwer Academic/Plenum, New York, NY, USA, 2nd edition, 1990.
16. P. Natale, T. den Blaauwen, C. van der Does, and A. J. M. Driessen, “Conformational state of the SecYEG-bound SecA probed by single tryptophan fluorescence spectroscopy,” Biochemistry, vol. 44, no. 17, pp. 6424–6432, 2005. View at Publisher · View at Google Scholar · View at PubMed
17. N. K. Tyagi, P. Goyal, A. Kumar, D. Pandey, W. Siess, and R. K. H. Kinne, “High-yield functional expression of human sodium/D-glucose cotransporter1 in Pichia pastoris and characterization of ligand-induced conformational changes as studied by tryptophan fluorescence,” Biochemistry, vol. 44, no. 47, pp. 15514–15524, 2005. View at Publisher · View at Google Scholar · View at PubMed
18. J. Amsterdam, D. Brunswick, and J. Mendels, “The clinical application of tricyclic antidepressant pharmacokinetics and plasma levels,” American Journal of Psychiatry, vol. 137, no. 6, pp. 653–662, 1980.
19. R. J. Baldessarini, “Drugs and the treatment of psychiatric disorders,” in The Pharmacological Basis of Therapeutics, A. G. Gilman and L. S. Goodman, Eds., pp. 418–427, Macmillan, New York, NY, USA, 6th edition, 1980.
20. A. Kuusinen, M. Arvola, and K. Keinänen, “Molecular dissection of the agonist binding site of an AMPA receptor,” The EMBO Journal, vol. 14, no. 24, pp. 6327–6332, 1995.
21. A. Ivanovic, H. Reiländer, B. Laube, and J. Kuhse, “Expression and initial characterization of a soluble glycine binding domain of the N-methyl-D-aspartate receptor NR1 subunit,” Journal of Biological Chemistry, vol. 273, no. 32, pp. 19933–19937, 1998. View at Publisher · View at Google Scholar
22. K. Keinänen, A. Jouppila, and A. Kuusinen, “Characterization of the kainate-binding domain of the glutamate receptor GluR-6 subunit,” Biochemical Journal, vol. 330, no. 3, pp. 1461–1467, 1998.