Antidepressant Interactions with the NMDA NR1-1b Subunit

Table 2

𝐾_sv values for the NMDA NR1-1b S1S2 apo domain and for the NR1-1b antidepressant complexes.

Antidepressant (family)	𝐾sv (𝜇M^−1)	Error in 𝐾sv(𝜇M^−1)
Desipramine (TCA)	2.67	0.10
Nortriptyline (TCA)	2.56	0.17
Imipramine (TCA)	3.15	0.06
Trimipramine (TCA)	3.02	0.21
Maprotiline (TCA)	5.92	0.47
Sertraline (SSRI)	2.23	0.10
Paroxetine (SSRI)	3.06	0.13
Fluvoxamine (SSRI)	3.77	0.07
Apo	1.61	0.11