An Overview of the Importance of Conformational Flexibility in Gene Regulation by the Transcription Factors

Figure 1

A model showing possible events/factors that may alter conformation of an ID domain/region of transcription factors to fold into a functionally active form. (a) An ID domain/region without any defined structure ((a) blue) may adopt a set of partially folded conformation ((b) red) due to specific events/factors shown here. This conformation may suit well for specific interactions with binding partners (purple) and result in functionally active conformation ((c) green) under physiological conditions.