EI of the Phosphotransferase System of Escherichia coli: Mathematical Modeling Approach to Analysis of Its Kinetic Properties

Figure 4

Catalytic cycle of Enzyme I in reduced form. Designations 𝑌: the sum of the concentrations of Nonphosphorylated monomer forms; 𝑌𝑃: the sum of the concentrations of the phosphorylated monomer forms; 𝑍: the sum of the concentrations of Nonphosphorylated dimer forms; 𝑍P: the sum of the concentrations of singly-phosphorylated dimer forms; 𝑍P2: the sum of the concentrations of the doubly-phosphorylated dimer forms. New rates correspond to the sums of the elementary processes rates (see explanation in the main text and Supplement). Dashed lines: phosphotransfer to HPr, dotted lines: dissociation (dimerization) reactions, other reactions are shown by the solid lines.