Redox Regulation of Calcium Signaling in Cancer Cells by Ascorbic Acid Involving the Mitochondrial Electron Transport Chain

<table>Influence of antimycin A on the ascorbate-induced Ca<sup>2+</sup> release from HEp-2 cells mitochondria. Concentrations in KRH: ascorbic acid—5 mM; antimycin A (<i>μ</i>M): 1—0, 2—10, 3—15. Number of cells in 1 mL—3 <svg height="8.5" id="M12" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.1 8.5" width="10.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,8.438)"><path d="M528 54l-36 -38l-198 201l-198 -201l-36 38l197 200l-197 201l36 38l198 -202l198 202l36 -38l-197 -201z" id="xD7"></path></g>
</svg> 10<sup>6</sup>. The arrow shows the instant of ascorbate addition.</table>

Journal of Biophysics

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Figure 2

Figure 2: Redox Regulation of Calcium Signaling in Cancer Cells by Ascorbic Acid Involving the Mitochondrial Electron Transport Chain 