A New Proof of Concept in Bacterial Reduction: Antimicrobial Action of Violet-Blue Light (405 nm) in Ex Vivo Stored Plasma

Figure 2

Inactivation of S. aureus contamination in 30 mL volumes of human plasma held in a closed sample dish by exposure to 405 nm light. (a) Three-dimensional model demonstrating the irradiance profile across the sample dish, with irradiance of ~8 mWcm⁻² at the centre. Populations of (b) 10³, (c) 10², and (d) 10¹ CFU mL⁻¹ were used as the seeding densities (n = 3 ± SE). Asterisks () represent data points, where the bacterial levels in light-exposed plasma were significantly different from the equivalent nonexposed control [].

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